LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS.

Introduction: The diagnosis and treatment of osteoporosis, a frequent age-related metabolic bone disorder, remain incomprehensive and challenging. The potential regulatory role of lncRNA XIST and sphingosine kinase 1 (SPHK1) pathway need experimental investigations.

Materials And Methods: RAW264.

The OLIF working corridor based on magnetic resonance imaging: a retrospective research.

Objective: To provide an anatomical basis for the development of oblique lumbar interbody fusion (OLIF) in Chinese patients.

Methods: Between November 2018 and June 2019, 300 patients' lumbar MRI data were reviewed. According to the Moro system and zone method described by us, the axial view was vertically divided into 6 zones (A, I II, III, IV, P) and was horizontally divided into 4 zones (R, a, b, c, L).

TNF-α/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT.

Background: Studies showed that upregulation of Nav1.6 increased the neuronal excitability and participated in neuropathic pain in the dorsal root ganglion (DRG). However, the molecular mechanisms underlying Nav1.

[Correlation of adult spinal sagittal imbalance and life quality].

Objective: To evaluate the correlation of spinal sagittal imbalance and life quality.

Methods: Radiographic analysis for 48 consecutive symptomatic patients with spinal sagittal imbalance was performed with posteroanterior and lateral standing radiographs. There were 12 males and 36 females with an average age of (66.

Role of death receptor, mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc.

Intervertebral disc (IVD) cell apoptosis has been suggested to play an important role in promoting the degeneration process. It has been demonstrated that IVD cell apoptosis occurs through either death receptor, mitochondrial or endoplasmic reticulum (ER) pathway. Our study aimed to explore the relationship among these three pathways and grade of IVD degeneration (IVDD).

[Experimental study of percutaneous vertebroplasty with a novel bone void filling container system].

Objective: To investigate vertebral augmentation with a novel reticulate bone filling container system by polymethyl methacrylate (PMMA) injection in cadaveric simulated vertebral compressive fracture and explore the effect of reticulate bone filling container on cement distribution controlling within vertebral body and the restoration of biomechanical properties after augmentation.

Methods: A total of 28 freshly frozen human vertebrae specimens were randomly divided into 4 groups. After the measurements of bone mineral density (BMD) and vertebral height, each vertebra received an axle load by a MTS (material testing system) machine to test the initial strength and stiffness.

The effect of screw length and bone cement augmentation on the fixation strength of iliac screws: a biomechanical study.

Study Design: Comparison of the biomechanical fixation strengths offered by 3 iliac screw fixation techniques: short screw, short screw augmented with cement, and long screw.

Objective: Evaluate the effect of screw length and bone cement augmentation on the fixation strength of iliac screw upon fatigue loading.

Summary Of Background Data: Iliac screws have been used in treating spinal disorders such as spinal deformity, spondylolisthesis, and sacral tumor.

The effects of punctured nucleus pulposus on lumbar radicular pain in rats: a behavioral and immunohistochemical study.

Object: Application of the nucleus pulposus (NP) to the nerve root has been developed as a model of lumbar radicular pain. The relationship between disc degeneration and the induction of radicular pain, however, has not yet been fully explored. The authors of this study investigated pain-related behaviors and expression of tumor necrosis factor-alpha (TNF-alpha) in the dorsal root ganglion (DRG) to evaluate the effects of punctured NP on lumbar radiculopathy.

Effect of iliac screw insertion depth on the stability and strength of lumbo-iliac fixation constructs: an anatomical and biomechanical study.

Study Design: Comparison of feasibility and safety of the placement of short and long iliac screws by anatomic and biomechanical evaluations as they apply to lumbo-iliac fixation construct.

Objective: To compare the stability of the short and long iliac screw fixations for lumbo-iliac reconstruction by anatomic and biomechanical evaluations.

Summary Of Background Data: Spinopelvic reconstruction remains a challenge to spine surgeons.

[Experimental study on spinal fusion induced by hBMP-4 gene modified tissue engineered bone].

Objective: To evaluate the efficacy of hBMP-4 gene modified tissue engineered bone graft in the enhancement of rabbit spinal fusion and find an ideal kind of substitute for the autograft bone.

Methods: Rabbit BMSCs were cultured and transfected with AAV-hBMP-4 using different MOI value. The optimal MOI value were determined by observing cell's morphology change.

[Biomechanical effect of the iliac screw insertion depth on lumbo-iliac fixation construct].

Objective: To biomechanically compare the stability of the short and long iliac screw fixation constructs in lumbo-iliac reconstruction.

Methods: Seven adult human embalmed cadavers (L(3)-pelvis) were used. Using posterior spinal fixation system, L(4)-S(1) pedicle screw fixation was performed.

[Sub-endplate microcirculation disturbance directly contributes to intervertebral disc degeneration].

Objective: To build sub-endplate microcirculation disturbance animal model and to investigate the potential pathogenesis of intervertebral disc degeneration (IVDD).

Methods: Twenty four New Zealand white rabbits were divided into treatment group (Group A) and control group (Group B). In Group A, animals received endotoxin and corticosteroid application to build sub-endplate microcirculation disturbance animal model, validated by microthrombus staining.

[One-stage single balloon multiple expansions percutaneous kyphoplasty: report of 18 cases].

Objective: To observe the effect and safety of one-stage single balloon multiple expansions percutaneous kyphoplasty (PKP) in treatment of osteoporotic vertebral compressive fracture (OVCF) and spinal tumor.

Methods: One-stage single balloon multiple expansions PKP was performed on 18 patients, 5 males and 13 females, aged 68.77 (44 - 80), with 45 vertebrae, including 11 case of OVCF (with 29 diseased vertebrae), 11 cases of multiple vertebral fracture (with 19 diseased vertebrae), 5 cases of multiple myeloma (with 12 diseased vertebrae), and 2 case of spinal metastatic tumor (with 4 diseased vertebrae), the vital signs were record during operation.