A Smart MMP-9-responsive Hydrogel Releasing M2 Macrophage-derived Exosomes for Diabetic Wound Healing.

Chronic diabetic wounds are characterized by prolonged inflammation and excessive accumulation of M1 macrophages, which impede the healing process. Therefore, resolving inflammation promptly and transitioning to the proliferative phase are critical steps for effective diabetic wound healing. Exosomes have emerged as a promising therapeutic strategy.

New insights into cyclopropanation: application in the synthesis of a novel high-heating-value hydrocarbon fuel derived from furfural.

Cyclopropanation is crucial in synthesizing high-heating-value fuels. experiments and computational studies provide new insights into the four-step cyclopropanation, where the high activity of Al carbenoid is attributed to the electron shift from olefin to Al carbenoid and high proximity of Al carbenoid with olefin.

Changes in hematoma volume following aneurysmal subarachnoid hemorrhage and its impact on patient prognosis.

Objective: This study aims to investigate the effects of preoperative intracerebral hematoma volume (HVpre), hematoma volume 6-8 days post-surgery (HVpost), and the rate of hematoma volume change (HVpre-HVpost)/HVpre on the prognosis of patients with aneurysmal subarachnoid hemorrhage (aSAH).

Materials And Methods: CT imaging data from 62 aSAH patients admitted to our hospital's Neurosurgery Department between January 2022 and December 2023 were obtained, both preoperatively and 6-8 days postoperatively. The hematoma volumes were measured using 3D-Slicer.

Neutrophil extracellular traps with low concentrations induce proliferation and migration of human fibroblasts via activating CCDC25/ILK/PI3K/AKT pathway.

Neutrophil plays an important role in the early stage of wound healing. Excessive neutrophil extracellular traps (NETs) which are produced by neutrophil have been proved as a significant unfavorable factor for wound healing by impairing the function of human skin fibroblasts. However, the effect of NETs with low concentrations on fibroblasts remains unclear.

Electrospun nanofibrous membranes meet antibacterial nanomaterials: From preparation strategies to biomedical applications.

Electrospun nanofibrous membranes (eNFMs) have been extensively developed for bio-applications due to their structural and compositional similarity to the natural extracellular matrix. However, the emergence of antibiotic resistance in bacterial infections significantly impedes the further development and applications of eNFMs. The development of antibacterial nanomaterials substantially nourishes the engineering design of antibacterial eNFMs for combating bacterial infections without relying on antibiotics.

Tuning the Local Environment of Pt Species at CNT@MO (M = Sn and Ce) Heterointerfaces for Boosted Alkaline Hydrogen Evolution.

As the most promising hydrogen evolution reaction (HER) electrocatalysts, platinum (Pt)-based catalysts still struggle with sluggish kinetics and expensive costs in alkaline media. Herein, we accelerate the alkaline hydrogen evolution kinetics by optimizing the local environment of Pt species and metal oxide heterointerfaces. The well-dispersed PtRu bimetallic clusters with adjacent MO (M = Sn and Ce) on carbon nanotubes (PtRu/CNT@MO) are demonstrated to be a potential electrocatalyst for alkaline HER, exhibiting an overpotential of only 75 mV at 100 mA cm in 1 M KOH.

Selenium Status Associates with Thyroid Hormone and Thyroid Dysfunction in Older Chinese Adults.

Selenium (Se) is physiologically essential for thyroid function. However, epidemiological studies on the association between Se status and thyroid function are limited and the results are inconsistent. Therefore, we explored this association in an elderly Chinese population sample.

Strong Acid Enabled Comprehensive Training of Poly (Sodium Acrylate) Hydrogel Networks.

The design of admirable hydrogel networks is of both practical and fundamental importance for diverse applications of hydrogels. Herein a general strategy of acid-assisted training is designed to enable multiple improvements of conventional poly (sodium acrylate) networks for hydrogels. Hydrophobic homogeneous crosslinked poly (sodium acrylate) hydrogels are prepared to verify the strategy.

Piezo-photocatalytic reduction of nitrates to N over silver dispersed on BaTiO@TiO.

This communication first achieved piezo-photocatalytic reduction of nitrates to N through designing an AgO/BaTiO@TiO core-shell catalyst. The built-in electric field induced by piezoelectric polarization suppresses photoexcited carrier recombination, and simultaneously causes energy band tilting, leading to the generation of electrons with higher reducibility to directly trigger the NO reduction to ˙NO, even without hole scavengers.

circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models.

Chronic wounds are a major complication in patients with diabetes. Here, we identify a therapeutic circRNA and load it into small extracellular vesicles (sEVs) to treat diabetic wounds in preclinical models. We show that circCDK13 can stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Low-Cytotoxic Core-Sheath ZnO NWs@TiON Triggered Piezo-photocatalytic Antibacterial Activity.

Sonophotodynamic antimicrobial therapy (SPDAT) is recognized as a highly efficient biomedical treatment option, known for its versatility and remarkable healing outcomes. Nevertheless, there is a scarcity of sonophotosensitizers that demonstrate both low cytotoxicity and exceptional antibacterial effectiveness in clinical applications. In this paper, a novel ZnO nanowires (NWs)@TiON core-sheath composite was developed, which integrates the piezoelectric effect and heterojunction to build dual built-in electric fields.

A feasibility study to predict 3D dose delivery accuracy for IMRT using DenseNet with log files.

Objective: This study aims to explore the feasibility of DenseNet in the establishment of a three-dimensional (3D) gamma prediction model of IMRT based on the actual parameters recorded in the log files during delivery.

Methods: A total of 55 IMRT plans (including 367 fields) were randomly selected. The gamma analysis was performed using gamma criteria of 3% /3 mm (Dose Difference/Distance to Agreement), 3% /2 mm, 2% /3 mm, and 2% /2 mm with a 10% dose threshold.

Analysis and Verification of Heat Dissipation Structures Embedded in Substrates in Power Chips Based on Square Frustums Thermal through Silicon Vias.

A novel heat dissipation structure composed of square frustums thermal through silicon via array and embedded in P-type (100) silicon substrate is proposed to improve the heat dissipation capacity of power chips while reducing process difficulty. Based on theoretical analysis, the heat transfer model and thermo-electric coupling reliability model of a power chip with the proposed heat dissipation structure are established. A comparative study of simulation indicates that the proposed heat dissipation structure, which can avoid problems such as softness, poor rigidity, fragility and easy fracture caused by thinning chips has better heat dissipation capability than thinning the substrate of power chips.

Galactinol synthase 2 influences the metabolism of chlorophyll, carotenoids, and ethylene in tomato fruits.

Galactinol synthase (GolS), which catalyses the synthesis of galactinol, is the first critical enzyme in the biosynthesis of raffinose family oligosaccharides (RFOs) and contributes to plant growth and development, and resistance mechanisms. However, its role in fruit development remains largely unknown. In this study, we used CRISPR/Cas9 gene-editing technology in tomato (Solanum lycopersicum) to create the gols2 mutant showing uniformly green fruits without dark-green shoulders, and promoting fruit ripening.

Predicting the error magnitude in patient-specific QA during radiotherapy based on ResNet.

Background: The error magnitude is closely related to patient-specific dosimetry and plays an important role in evaluating the delivery of the radiotherapy plan in QA. No previous study has investigated the feasibility of deep learning to predict error magnitude.

Objective: The purpose of this study was to predict the error magnitude of different delivery error types in radiotherapy based on ResNet.

MiR-17-5p-engineered sEVs Encapsulated in GelMA Hydrogel Facilitated Diabetic Wound Healing by Targeting PTEN and p21.

Delayed wound healing is a major complication of diabetes, and is associated with impaired cellular functions. Current treatments are unsatisfactory. Based on the previous reports on microRNA expression in small extracellular vesicles (sEVs), miR-17-5p-engineered sEVs (sEVs) and encapsulated them in gelatin methacryloyl (GelMA) hydrogel for diabetic wounds treatment are fabricated.

P-MSC-derived extracellular vesicles facilitate diabetic wound healing via miR-145-5p/ CDKN1A-mediated functional improvements of high glucose-induced senescent fibroblasts.

Background: Persistent hyperglycaemia in diabetes causes functional abnormalities of human dermal fibroblasts (HDFs), partially leading to delayed skin wound healing. Extracellular vesicles (EVs) containing multiple pro-healing microRNAs (miRNAs) have been shown to exert therapeutic effects on diabetic wound healing. The present study aimed to observe the effects of EVs derived from placental mesenchymal stem cells (P-MSC-EVs) on diabetic wound healing and high glucose (HG)-induced senescent fibroblasts and to explore the underlying mechanisms.

MiR-141-3p-Functionalized Exosomes Loaded in Dissolvable Microneedle Arrays for Hypertrophic Scar Treatment.

Hypertrophic scar (HS) is a common fibroproliferative disease caused by abnormal wound healing after deep skin injury. However, the existing approaches have unsatisfactory therapeutic effects, which promote the exploration of newer and more effective strategies. MiRNA-modified functional exosomes delivered by dissolvable microneedle arrays (DMNAs) are expected to provide new hope for HS treatment.

Mechanism and Solution of Overcharge Effect in Lithium-Sulfur Batteries.

Increasing the sulfur cathode load is an important method for promoting the commercialization of lithium-sulfur batteries. However, there is a common problem of overcharging in high-loading experiments, which is rarely reported. In this work, it is believed that an insulating layer of S forms on the current collector surface, hindering electron exchange with polysulfides.

Autophagosomes Defeat Ferroptosis by Decreasing Generation and Increasing Discharge of Free Fe in Skin Repair Cells to Accelerate Diabetic Wound Healing.

Ferroptosis plays an essential role in the development of diabetes and its complications, suggesting potential therapeutic strategies targeting ferroptosis. Secretory autophagosomes (SAPs) carrying cytoplasmic cargoes have been recognized as novel nano-warrior to defeat diseases. Here, it is hypothesized that SAPs derived from human umbilical vein endothelial cells (HUVECs) can restore the function of skin repair cells by inhibiting ferroptosis to promote diabetic wound healing.

Tunable Pt-Ni Interaction Induced Construction of Disparate Atomically Dispersed Pt Sites for Acidic Hydrogen Evolution.

Developing cost-effective Pt-based electrocatalysts for the hydrogen evolution reaction (HER) is highly urgent. Herein, we report novel electrocatalysts with individually dispersed Pt active sites and tunable Pt-Ni interaction decorated on carbon-wrapped nanotube frameworks (Pt/Ni-DA). Pt/Ni-DA exhibits superior HER performance at low Pt concentrations with an ultralow overpotential of 18 mV at 10 mA cm and an ultrahigh mass activity of 2.

Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles.

Neutrophil extracellular traps (NETs) have been considered a significant unfavorable factor for wound healing in diabetes, but the mechanisms remain unclear. The therapeutic application of small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) has received considerable attention for their properties. Hypoxic preconditioning is reported to enhance the therapeutic potential of MSC-derived sEVs in regenerative medicine.

Image-based features in machine learning to identify delivery errors and predict error magnitude for patient-specific IMRT quality assurance.

Objective: To identify delivery error type and predict associated error magnitude by image-based features using machine learning (ML).

Methods: In this study, a total of 40 thoracic plans (including 208 beams) were selected, and four error types with different magnitudes were introduced into the original plans, including 1) collimator misalignment (COLL), 2) monitor unit (MU) variation, 3) systematic multileaf collimator misalignment (MLCS), and 4) random MLC misalignment (MLCR). These dose distributions of portal dose predictions for the original plans were defined as the reference dose distributions (RDD), while those for the error-introduced plans were defined as the error-introduced dose distributions (EDD).

Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells Attenuates Surgical Wound-Induced Blood-Brain Barrier Dysfunction in Mice.

Blood-brain barrier (BBB) is the most important component of central nervous system (CNS) to keep toxins and pathogens from CNS. Although our studies demonstrated that using interleukin-6 antibodies (IL-6-AB) reversed the increased permeability of BBB, IL-6-AB is limited in their application that only could be used a few hours before surgery and seemed delayed the surgical wounds healing process, which urges us to find another more effective method. In this study, we employed the C57BL/6J female mice to investigate the potential effects of umbilical cord-derived mesenchymal stem cells (UC-MSCs) transplantation on BBB dysfunction induced by surgical wound.