Loss-Induced Violation of the Fundamental Transmittance-Asymmetry Bound in Nonlinear Complex Wave Systems.

Nonlinearity-induced asymmetric transport (AT) can be utilized for on-chip implementation of nonreciprocal devices that do not require odd-vector biasing. This scheme, however, is subject to a fundamental bound dictating that the maximum transmittance asymmetry is inversely proportional to the asymmetry intensity range (AIR) over which AT occurs. Contrary to the conventional wisdom, we show that the implementation of losses can lead to an increase of the AIR without deteriorating the AT.

Implications of Spectral Interlacing for Quantum Graphs.

Quantum graphs are ideally suited to studying the spectral statistics of chaotic systems. Depending on the boundary conditions at the vertices, there are Neumann and Dirichlet graphs. The latter ones correspond to totally disassembled graphs with a spectrum being the superposition of the spectra of the individual bonds.

[Hypertrophic cardiomyopathies and ATTR amyloidosis - a current review for clinical practice].

Cardiomyopathies include dilated and restrictive cardiomyopathies as well as the various forms of hypertrophic cardiomyopathies (HCM). By definition, HCM is considered to occur when left ventricular wall thickness is ≥ 15 mm. This may be masked by genetic sarcomeric diseases, storage diseases, or syndromes.

The Spontaneous Course of Human Herpesvirus 6 DNA-Associated Myocarditis and the Effect of Immunosuppressive Intervention.

Introduction: This study investigated the spontaneous clinical course of patients with endomyocardial biopsy (EMB)-proven lymphocytic myocarditis and cardiac human herpesvirus 6 (HHV6) DNA presence, and the effectiveness of steroid-based intervention in HHV6-positive patients.

Results: 756 heart failure (HF) patients underwent an EMB procedure to determine the underlying cause of unexplained HF. Low levels of HHV6 DNA, detectable by nested PCR only, were found in 10.

Microwave graph analogs for the voltage drop in three-terminal devices with orthogonal, unitary, and symplectic symmetry.

Transmission measurements through three-port microwave graphs are performed, in analogy to three-terminal voltage drop devices with orthogonal, unitary, and symplectic symmetry. The terminal used as a probe is symmetrically located between two chaotic subgraphs, and each graph is connected to one port, the input and the output, respectively. The analysis of the experimental data clearly exhibits the weak localization and antilocalization phenomena.

Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis.

Aim: The acute phase of a coxsackievirus 3 (CVB3)-induced myocarditis involves direct toxic cardiac effects and the systemic activation of the immune system, including the cardiosplenic axis. Consequently, the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome pathway is activated, which plays a role in disease pathogenesis and progression. The anti-inflammatory drug colchicine exerts its effects, in part, via reducing NLRP3 activity, and has been shown to improve several cardiac diseases, including acute coronary syndrome and pericarditis.

Diffuse field cross-correlations: Scattering theory and electromagnetic experiments.

The passive estimation of impulse responses from ambient noise correlations arouses increasing interest in seismology, acoustics, optics, and electromagnetism. Assuming the equipartition of the noise field, the cross-correlation function measured with noninvasive receiving probes converges towards the difference of the causal and anticausal Green's functions. Here, we consider the case when the receiving field probes are antennas which are well coupled to a complex medium-a scenario of practical relevance in electromagnetism.

Spectral duality in graphs and microwave networks.

Quantum graphs and their experimental counterparts, microwave networks, are ideally suited to study the spectral statistics of chaotic systems. The graph spectrum is obtained from the zeros of a secular determinant derived from energy and charge conservation. Depending on the boundary conditions at the vertices, there are Neumann and Dirichlet graphs.

Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.

Mathematical learning deficits are defined as a neurodevelopmental disorder (dyscalculia) in the International Classification of Diseases. It is not known, however, how such deficits emerge in the course of early brain development. Here, we conducted functional and structural magnetic resonance imaging (MRI) experiments in 3- to 6-year-old children without formal mathematical learning experience.

Wearable cardioverter-defibrillator: friend or foe in suspected myocarditis?

Aim: Wearable cardioverter defibrillator (WCD, LifeVest, and Zoll) therapy has become a useful tool to bridge a temporarily increased risk for sudden cardiac death. However, despite extensive use, there is a lack of evidence whether patients with myocarditis and impaired LVEF may benefit from treatment with a WCD.

Methods And Results: We conducted a single-centre retrospective observational study analysing patients with a WCD prescribed between September 2015 and April 2020 at our institution.

Resting-State Functional Connectivity in Mathematical Expertise.

To what extent are different levels of expertise reflected in the functional connectivity of the brain? We addressed this question by using resting-state functional magnetic resonance imaging (fMRI) in mathematicians versus non-mathematicians. To this end, we investigated how the two groups of participants differ in the correlation of their spontaneous blood oxygen level-dependent fluctuations across the whole brain regions during resting state. Moreover, by using the classification algorithm in machine learning, we investigated whether the resting-state fMRI networks between mathematicians and non-mathematicians were distinguished depending on features of functional connectivity.

Experimental Tuning of Transport Regimes in Hyperuniform Disordered Photonic Materials.

We present wave transport experiments in hyperuniform disordered arrays of cylinders with high dielectric permittivity. Using microwaves, we show that the same material can display transparency, photon diffusion, Anderson localization, or a full band gap, depending on the frequency ν of the electromagnetic wave. Interestingly, we find a second weaker band gap, which appears to be related to the second peak of the structure factor.

Non-Hermitian CT-Symmetric Spectral Protection of Nonlinear Defect Modes.

We investigate, using a microwave platform consisting of a non-Hermitian Su-Schrieffer-Heeger array of coupled dielectric resonators, the interplay of a lossy nonlinearity and CT symmetry in the formation of defect modes. The measurements agree with the theory which predicts that, up to moderate pumping, the defect mode is an eigenstate of the CT-symmetric operator and retains its frequency at the center of the gap. At higher pumping values, the system undergoes a self-induced explicit CT-symmetry violation which removes the spectral topological protection and alters the shape of the defect mode.

Observation of supersymmetric pseudo-Landau levels in strained microwave graphene.

Using an array of coupled microwave resonators arranged in a deformed honeycomb lattice, we experimentally observe the formation of pseudo-Landau levels in the whole crossover from vanishing to large pseudomagnetic field strengths. This result is achieved by utilising an adaptable setup in a geometry that is compatible with the pseudo-Landau levels at all field strengths. The adopted approach enables us to observe the fully formed flat-band pseudo-Landau levels spectrally as sharp peaks in the photonic density of states and image the associated wavefunctions spatially, where we provide clear evidence for a characteristic nodal structure reflecting the previously elusive supersymmetry in the underlying low-energy theory.

Implementing nonuniversal features with a random matrix theory approach: Application to space-to-configuration multiplexing.

We consider the efficiency of multiplexing spatially encoded information across random configurations of a metasurface-programmable chaotic cavity in the microwave domain. The distribution of the effective rank of the channel matrix is studied to quantify the channel diversity and to assess a specific system's performance. System-specific features such as unstirred field components give rise to nontrivial interchannel correlations and need to be properly accounted for in modeling based on random matrix theory.

QRS fragmentation as a possible electrocardiographic diagnostic marker in patients with acute myocarditis: preliminary histopathological validation.

Aims: We aim to assess the reproducibility of QRS fragmentation (fQRS) on a multi-centre dataset of patients with acute myocarditis (AM), including a histopathological validation in a subgroup with biopsy-proven disease. Electrocardiogram (ECG) in patients with myocarditis is usually considered aspecific. ST changes and conduction anomalies have been commonly reported so far.

Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis.

Aims: The alarmin S100A8/S100A9 (S100A8/A9) is released by activated monocytes/macrophages and neutrophils in the setting lymphocytic myocarditis (MC). We recently demonstrated its therapeutic potential in experimental acute MC. Now, we investigated the diagnostic relevance of S100A8/A9 serum levels in patients with suspected acute and chronic MC and in patients with heart failure without cardiac inflammation.

Microwave Realization of the Chiral Orthogonal, Unitary, and Symplectic Ensembles.

Random matrix theory has proven very successful in the understanding of the spectra of chaotic systems. Depending on symmetry with respect to time reversal and the presence or absence of a spin 1/2 there are three ensembles, the Gaussian orthogonal (GOE), Gaussian unitary (GUE), and Gaussian symplectic (GSE) one. With a further particle-antiparticle symmetry the chiral variants of these ensembles, the chiral orthogonal, unitary, and symplectic ensembles (the BDI, AIII, and CII in Cartan's notation) appear.

The emergence of dyslexia in the developing brain.

Developmental dyslexia, a severe deficit in literacy learning, is a neurodevelopmental learning disorder. Yet, it is not clear whether existing neurobiological accounts of dyslexia capture potential predispositions of the deficit or consequences of reduced reading experience. Here, we longitudinally followed 32 children from preliterate to school age using functional and structural magnetic resonance imaging techniques.

Early cortical surface plasticity relates to basic mathematical learning.

Children lay the foundation for later academic achievement by acquiring core mathematical abilities in the first school years. Neural reorganization processes associated with individual differences in early mathematical learning, however, are still poorly understood. To fill this research gap, we followed a sample of 5-6-year-old children longitudinally to the end of second grade in school (age 7-8 years) combining magnetic resonance imaging (MRI) with comprehensive behavioral assessments.

Global plasma protein profiling reveals DCM characteristic protein signatures.

To identify potential biomarkers supporting better phenotyping and to improve understanding of the pathophysiology of dilated cardiomyopathy (DCM), this study comparatively analyzed plasma protein profiles of DCM patients and individuals with low normal and normal left ventricular ejection fraction (LVEF) by mass spectrometry. After plasma depletion using a MARS Hu-6 column, global proteome profiling was performed using a LTQ-Orbitrap Velos mass spectrometer. To compare and confirm results, two different discovery sets of samples were investigated.

Targeting CD20+ B-lymphocytes in inflammatory dilated cardiomyopathy with rituximab improves clinical course: a case series.

Background: The aetiology of dilated cardiomyopathy (DCM) is highly heterogeneous including genetic and/or acquired (infective, toxic, immune, endocrine, and nutritional) factors. The major part of acquired DCM in developed countries is caused by either viral or autoimmune myocarditis. It is believed that the activation of the T-lymphocyte cell system is the major pathomechanism underlying autoimmune myocarditis and inflammatory DCM (DCMi).

Mathematical expertise modulates the architecture of dorsal and cortico-thalamic white matter tracts.

To what extent are levels of cognitive expertise reflected in differential structural connectivity of the brain? We addressed this question by analyzing the white matter brain structure of experts (mathematicians) versus non-experts (non-mathematicians) using probabilistic tractography. Having mathematicians and non-mathematicians as participant groups enabled us to directly compare profiles of structural connectivity arising from individual levels of expertise in mathematics. Tracking from functional seed regions activated during the processing of complex arithmetic formulas revealed an involvement of various fiber bundles such the inferior fronto-occipital fascicle, arcuate fasciculus/superior longitudinal fasciculus (AF/SLF), cross-hemispheric connections of frontal lobe areas through the corpus callosum and cortico-subcortical connectivity via the bilateral thalamic radiation.

Telbivudine Reduces Parvovirus B19-Induced Apoptosis in Circulating Angiogenic Cells.

Human parvovirus B19 (B19V) infection directly induces apoptosis and modulates CXCR4 expression of infected marrow-derived circulating angiogenic cells (CACs). This leads to dysfunctional endogenous vascular repair. Treatment for B19V-associated disease is restricted to symptomatic treatment.