Trends in prescribing montelukast in patients with asthma in real-life: Results from the Turkish adult asthma registry.

Montelukast, a leukotriene receptor antagonist (LTRA) approved for the treatment of asthma and allergic rhinitis, is widely used, though real-world data on its application in asthma management remain limited. This registry-based study evaluated the use of montelukast in adult asthma patients, examining demographic and disease characteristics, asthma control status, asthma phenotypes, presence of atopy, and treatment regimens. Among 2053 patients analyzed, 61.

Shear Wave Elastography in AV Fistula Thrombosis: Differentiating Thrombus Age and Assessing Clinical Outcomes of Balloon Angioplasty.

Objectives: To evaluate the role of shear wave elastography (SWE) in distinguishing acute from subacute thrombi in thrombosed arteriovenous fistulas (AVFs) and explore the relationship between thrombus stiffness and outcomes of balloon angioplasty.

Materials And Methods: This retrospective study included 44 dialysis patients with thrombosed AVFs from June 2022 to June 2024. Patients underwent Doppler ultrasound and SWE to assess thrombus age, followed by balloon angioplasty.

Biomarkers.

Background: Lewy body disease (LBD) often co-occurs with Alzheimer's disease neuropathological change (ADNC), which can be detected using plasma pTau181 and pTau217. Few studies have investigated these biomarkers in LBD, nor have studies investigated plasma pTau217 in Parkinson's disease (PD) cognitively normal patients (LBD-CN), or in alpha-synuclein positive (asyn-positive) participants. Furthermore, uncertainties remain regarding LBD-specific cut-points for these biomarkers.

Biomarkers.

Background: Alzheimer's disease (AD) is a significant global health issue that affects both individuals and society for older adults. Early detection is essential in Alzheimer's disease, as there is no definite treatment, and prevention is possible through early detection. In the studies of Alzheimer's disease, different approaches are used to understand the characteristics of the disease, including imaging methods such as MRI scans, biomarkers, and quantitative data from MRI scans.

Unsymmetric triazine-based triglucoside detergents for membrane protein stability.

Membrane proteins play a crucial role in a variety of biological processes and are key targets for pharmaceutical development. Structural studies of membrane proteins provide molecular insights into the mechanisms of these processes and are essential for effective drug discovery. Historically, these studies have relied on solubilization of the target protein using detergents, but conventional detergents often fail to maintain the stability of challenging membrane proteins.

Evaluating postoperative complications in standard percutaneous nephrolithotomy for renal stones larger than 2 cm: a retrospective study utilizing the E-PASS scoring system.

Percutaneous nephrolithotomy (PCNL) is a widely preferred method for treating complex kidney stones, particularly in patients with larger or more complicated stones. Despite its advantages, such as minimal invasiveness and a shorter recovery time, postoperative complications can occur, thereby necessitating effective risk assessment tools to identify at-risk patients. This study evaluated the Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system's utility in predicting postoperative complications following standard PCNL.

The Effectiveness of Salivary Sampling for the Detection and Quantification of in Periodontitis Patients.

The objective was to evaluate using unstimulated saliva in detecting and to compare the saliva and subgingival and mucosa membrane occurrence of this periodontal pathogen in patients diagnosed with advanced periodontitis. Patients with advanced forms of periodontitis ( = 220; mean age: 54.03 ± 03 years) at stage III/IV were sampled.

Association Between Baseline and Changes in Early Neutrophil-to-Lymphocyte Ratio on Survival in Patients with Metastatic Bladder Carcinoma Treated with Immunotherapy.

: A high baseline neutrophil-to-lymphocyte ratio (NLR) is a poor prognostic factor in various cancers. However, its predictive role in metastatic bladder cancer (mBC) treated with immunotherapy is unclear. In this study, we aimed to investigate the relationship between the baseline and change in NLR and overall survival in mBC patients treated with immunotherapy, with the potential to significantly impact patient care.

Effects of Cerium Oxide on Kidney and Liver Tissue Damage in an Experimental Myocardial Ischemia-Reperfusion Model of Distant Organ Damage.

Ischemia-reperfusion (I/R) injury is a process in which impaired perfusion is restored by restoring blood flow and tissue recirculation. Nanomedicine uses cutting-edge technologies that emerge from interdisciplinary influences. In the literature, there are very few in vivo and in vitro studies on how cerium oxide (CeO) affects systemic anti-inflammatory response and inflammation.

Radiological Perspectives in Congenital Sensorineural Hearing Loss: Insights from Cochlear Implant Candidates.

Congenital hearing loss is a significant health concern, with diverse etiologies encompassing cochlear and cochleovestibular pathologies. Preoperative radiological evaluation in cochlear implant candidates is pivotal for treatment planning. We aim to elucidate the spectrum of radiological findings in patients with congenital hearing loss undergoing cochlear implant assessment.

Neurodevelopmental Effects of Propranolol Treatment During Infancy in Infantile Hemangioma Patients.

Introduction And Aim: Propranolol is an effective treatment option for infantile hemangiomas, but there is still insufficient information about neurodevelopmental side effects of propranolol. In our study, the neurodevelopmental levels of infantile hemangioma patients receiving propranolol treatment were examined using the Bayley-III test.

Method: In our single-center, cross-sectional study, patients were recruited between 1 January 2020 and 31 December 2023.

Artificial Intelligence for Tooth Detection in Cleft Lip and Palate Patients.

Cleft lip and palate patients often present with unique anatomical challenges, making dental anomaly detection and numbering particularly complex. The accurate identification of teeth in these patients is crucial for effective treatment planning and long-term management. Artificial intelligence (AI) has emerged as a promising tool for enhancing diagnostic precision, yet its application in this specific patient population remains underexplored.

Health behind bars: obesity and cardiometabolic risk according to different indicators in incarcerated men.

Purpose: This study aims to evaluate the obesity and cardiometabolic disease risks of incarcerated men and to determine the related factors.

Design/methodology/approach: This study was cross-sectional and 139 incarcerated men were included. Data were collected using a questionnaire containing the Descriptive Information Form and the Pittsburgh Sleep Quality Index.

Predictive value of nutritional scores in non-valvular atrial fibrillation patients: Insights from the AFTER-2 study.

Background And Aim: Many scoring systems are used to evaluate malnutrition, but there is no consensus on which scoring system would be more appropriate. We aimed to investigate the effect of malnutrition in patients with non-valvular atrial fibrillation (NVAF) and to compare three scoring systems.

Methods And Results: A total of 2592 patients with non-valvular AF from 35 different centers in Turkey were included in this prospective study.

The Role of Acetylcholinesterase Enzyme Inhibitor Rivastigmine on Spike-Wave Discharges, Learning-Memory, Anxiety, and TRPV1 Channel Expression in Genetic Absence Epileptic WAG/Rij Rats.

In the present study, the effects of the acetylcholinesterase (AChE) enzyme inhibitor rivastigmine (RIVA) on spike-wave discharges (SWDs), memory impairment, anxiety-like behavior, and the transient receptor potential vanilloid 1 (TRPV1) gene expression were investigated in genetic absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. After tripolar electrodes were implanted on the WAG/Rij rats' skulls, single doses of 0.125, 0.

Effect of dietary supplementation of jujube fruit (Ziziphus jujuba) powder on performance, some biochemical parameters, and egg quality in quails (Coturnix coturnix japonica).

This study aimed to evaluate the effects of different dietary supplementation levels with jujube fruit powder on the performance, biochemical parameters, and egg quality characteristics of laying quails. A total of 60 quails (45 days old) were randomly assigned to treatments with different levels of jujube fruit powder: a basal diet (control) and diets supplemented with 5 g/kg (T1), 10 g/kg (T2), with five replicates per treatment (20 quails/treatment and four quails/replicate). The differences between 1-15 and 16-30 days for feed intake (p<0.

Evaluating LLM-based generative AI tools in emergency triage: A comparative study of ChatGPT Plus, Copilot Pro, and triage nurses.

Background: The number of emergency department (ED) visits has been on steady increase globally. Artificial Intelligence (AI) technologies, including Large Language Model (LLMs)-based generative AI models, have shown promise in improving triage accuracy. This study evaluates the performance of ChatGPT and Copilot in triage at a high-volume urban hospital, hypothesizing that these tools can match trained physicians' accuracy and reduce human bias amidst ED crowding challenges.

Determination of HLA Tissue Type According to the Etiology of Patients with Chronic Renal Failure.

Objective: Chronic kidney disease (CKD) is a prominent public health concern, is defined as functional and structural damage to the kidneys. This study aims to investigate the association between human leukocyte antigen (HLA) alleles individuals with CKD and the different etiological subgroups of diesease.

Methods: Genomic DNA was obtained from peripheral blood samples of 1,079 patients with retrospective CKD and 1,111 healthy control individuals.

Analysis of the relationship between medical achievement self-efficacy perception and impostor phenomenon in the postgraduate education process: a cross-sectional study.

Background: This study aimed to assess the correlation between the impostor phenomenon and the level of academic self-efficacy. The secondary aim was to determine the sociodemographic variables affecting these two conditions. Based on the acquired findings, it is possible to take supportive and preventive measures.

[Gender distribution of scientific contributions at German ophthalmological conferences-a baseline study].

Background: The proportion of female ophthalmologists in Germany has risen to approximately 50% in recent years, and approximately 66% of medical students are women. This represents a reversal of the past situation with a male predominance. Despite this change, many international studies show that women are still underrepresented at scientific conferences, particularly among invited speakers, chairpersons, and program committees.

Drug-refractory irritability and related factors in autistic children.

Objectives: Autistic children frequently exhibit irritability, which can manifest as aggression, self-injurious behaviour, and severe tantrums, leading to significant impairments. Two atypical antipsychotics have been licensed by the Food and Drug Administration for the treatment of irritability in autistic children, although a significant percentage of these children do not respond to this treatment. This study aimed to determine the frequency of drug refractory irritability (DRI) and identify the risk factors in a large clinical sample of autistic children.

Evaluating single-dose methotrexate alone versus methotrexate with letrozole for treating ectopic pregnancy: a comparative study.

Purpose: Ectopic pregnancy (EP) constitutes 1-2% of all pregnancies. Methotrexate (MTX) is commonly used in treating EP, but it has some limitations and potential side effects. Clinical studies have shown that letrozole, an aromatase inhibitor, may potentially be used in conjunction with MTX therapy.

Treatment Patterns and Attrition in Metastatic Renal Cell Carcinoma: Real-Life Experience from the Turkish Oncology Group Kidney Cancer Consortium (TKCC) Database.

Introduction: Despite the rapid evolution in management of metastatic renal cell carcinoma (mRCC) over the past decade, challenges remain in accessing new therapies in some parts of the world. Despite therapeutic advancements, attrition rates remain persistently high. This study aims to assess the treatment patterns and attrition rates of patients with mRCC in oncology clinics across Turkey.