Investigating the Anti-Inflammatory Potential of SLC-0111: A Carbonic Anhydrase Inhibitor Targeting Cyclooxygenase-Mediated Inflammatory Pathways in a Carrageenan-Induced Rat Model.

Inflammation is a fundamental physiological reaction that leads to the development of many diseases, including tissue damage, asthma, diabetes, atherosclerosis, inflammatory bowel disease, and cancer. The enzyme COX is a vital mediator in inflammatory processes. Interestingly, the COX enzyme possesses multiple structural similarities to the carbonic anhydrase enzyme.

Elexacaftor/Tezacaftor/Ivacaftor Treatment Accessibility and Mental Health: Reducing Anxiety in People With Cystic Fibrosis.

Background: Although modulator therapies have proven effective in cystic fibrosis (CF) access is limited due to reimbursement issues in Turkey. We aimed to examine anxiety and depression levels of people with CF (pwCF) and their caregivers according to their access to modulator treatment.

Methods: Participants genetically eligible for elexacaftor/tezacaftor/ivacaftor (ETI) were divided into Group 1 (access via court decision, not yet on treatment) and Group 2 (unable to access due to reimbursement issues).

Fat mass is responsible for increased plasma and whole blood viscosity in obesity.

Objectives: Our study is centered around a pivotal question: How does the increase in adipose tissue, which defines obesity, impact hemorheological parameters? By delving into this question, we aim to underscore the crucial role of fat tissue increase in obesity, a topic of significant interest and importance in the field of physiology and obesity research.

Methods: Individuals with a body mass index (BMI) of 25 and above were included in this study. Height was measured with bare feet on flat surface, then, using the bioimpedance device (Tanita-BC418), weight, BMI, fat percentage, fat mass (FM), and fat-free mass were determined.

Trade-offs between resilience, sustainability and cost in the US agri-food transportation infrastructure.

Agricultural and food supply chains in the United States are essential for both global and local food security, yet the transportation of agri-food commodities has received little attention despite being an essential feature for connecting production to consumption. Here we map the US agri-food distribution onto real-world highways, railways and waterways and also quantify the trade-offs between cost, path redundancy and carbon emissions of agri-food transit across transportation modes. Highways show the greatest path redundancy; relative to waterways, highways also cost 3 orders of magnitude more and emit 60 times more carbon.

4-meter walk test in patients with Parkinson's disease: A reliability and validity study.

Objective: The purpose of the study was to examine the test-retest reliability of the 4-Meter Walk Test (4-MWT), the minimum detectable change (MDC) in the 4-MWT, and the concurrent and known-group validity of the 4-MWT in patients with Parkinson Disease (PwPD).

Design: A total of 42 PwPD and 33 healthy people participated in this study. Reliability was quantified using intraclass correlation coefficients (ICC) and the MDC.

Malaria in Turkey: A comprehensive analysis of diagnosis, treatment, and the impact of COVID-19, ten years after malaria elimination (2012-2023).

Background: The characteristics, diagnosis, and treatment stages of malaria in Turkey in the last ten years are not known except few case reports. We aimed to describe the details of the diagnosis and treatment practices of malaria cases in various hospitals across Turkey between 2012 and 2023 after the declaration of the elimination of malaria.

Methods: We collected the patient data from 30 centers by using Qualtrics Survey Software.

The Effects of COVID-19 on Tinnitus Severity and Quality of Life in Individuals With Subjective Tinnitus.

Purpose: This study aimed to investigate the effects of the SARS-CoV-2 virus (COVID-19) on tinnitus severity and quality of life in infected and non-infected individuals who were re-admitted to our clinic after the COVID-19 outbreak.

Methods: The study involved both retrospective and prospective data analysis. The study included 30 individuals aged 20-65 years with normal hearing who had undergone psychoacoustic, tinnitus, and psychosomatic evaluations before the pandemic.

Long-term Home Mechanical Ventilation of Children in İstanbul.

Objective: The aims of this multi-center study were to describe the characteristics of children receiving long-term home mechanical ventilation (HMV) in İstanbul and to compare the patients receiving non-invasive and invasive ventilation.

Material And Methods: This cross-sectional multicenter study included all children receiving long-term HMV followed by admission to six tertiary hospitals. The data were collected between May 2020 and May 2021.

Venous ulcers in Behçet syndrome.

Introduction: Post-thrombotic syndrome (PTS) and stasis ulcers are late complications of deep vein thrombosis (DVT) in Behçet's syndrome (BS). We aimed to determine the clinical and histopathological characteristics, treatment modalities, and outcomes in BS patients with stasis ulcers.

Method: We included 63 BS patients with stasis ulcers from a total of 310 with vascular involvement, seen at a multidisciplinary center between January 2021 and July 2022.

Implementation of Cystic Fibrosis Responsibility, Independence, Self-Care, Education Program Enhances Cystic Fibrosis Knowledge in Limited Resource Country: Results From a Randomized Controlled Trial.

Background: CF R.I.S.

Comparison of morbidity and mortality outcomes of conventional and sutureless repair techniques in children with isolated total anomalous pulmonary venous drainage.

Objectives: The sutureless repair technique has been favoured due to its purported reduction in post-operative pulmonary venous obstruction rates. This study aims to compare the outcomes of conventional versus sutureless repair techniques in Total Anomalous Pulmonary Venous Drainage.

Methods: In this retrospective single-centre analysis (2012-2022), we evaluated children who underwent conventional or sutureless repair for isolated total anomalous pulmonary venous drainage, excluding complex cardiac anomalies and incomplete data.

Co-existing autonomous cortisol secretion in primary aldosteronism.

Aim: Co-existing primary aldosteronism (PA) and autonomous cortisol secretion (ACS) has been recently recognized as a distinct entity. This study aimed to assess the incidence of ACS in patients with PA, and its impact on clinical and laboratory parameters.

Methods: Ninety-two patients diagnosed with PA were included.

Assessment of diabetes-specific eating disorder risk in adult patients with diabetes.

Purpose: Adults with type 1 diabetes (T1D) are reported to be at higher risk for clinical eating disorders (ED) and other disordered eating behaviors (DEB) than their peers without diabetes. On the other hand, there is insufficient data on DEB in adults with type 2 diabetes (T2D). Our study aimed to investigate the prevalence of DEB in patients with T1D and T2D on intensive insulin therapy followed in our outpatient clinic.

The Effect of Swing on Stress and Comfort in Premature Newborns: A Randomised Controlled Trial.

Objectives: The study was conducted to investigate the effect of swing on stress and comfort in premature newborns who could not be reunited with their mothers.

Methods: The study was conducted in a randomised controlled experimental design. The intervention group included newborns who received swing intervention (n = 64) and the control group included newborns who did not receive swing intervention (n = 64).

Extracellular Matrix Alterations Due to Early-Life Adversity: Implications for Auditory Learning in Male Sprague-Dawley Rats.

This study aimed to investigate the impact of early childhood chronic stress on the development of the brain extracellular matrix (ECM) and how alterations in the ECM following early-life adversity (ELA) affect auditory learning and cognitive flexibility. ELA was induced through a combination of maternal separation and neonatal isolation in male Sprague-Dawley rats, and the success of the ELA model was assessed behaviorally and biochemically. A cortex-dependent go/no-go task with two phases was used to determine the impact of ELA on auditory learning and cognitive flexibility.

National Registry for Home Mechanical Ventilation in Children from Turkey.

Background: Advances in neonatal and pediatric intensive care have improved patient survival rates, emphasizing the need for respiratory support in cases of chronic respiratory failure, resulting in the establishment of the Turkish National Pediatric Patients Receiving Home Mechanical Ventilation (HMV) Support Registration System in 2023. This study aims to present the initial findings of the registry.

Methods: In this cross-sectional study, epidemiological and demographic data were obtained from the registry and compared between invasive ventilation (IV) and non-IV (NIV) groups.

Microbial Contamination of Nebulizers in Patients With Cystic Fibrosis.

Objective: Nebulizer contamination has potential harmful effects on the respiratory system. The aim was to investigate the contamination profile of the nebulizers in cystic fibrosis patients and evaluate the relationship between hygiene practices and microbial contamination. Materials and Methods: Microbiological swab samples were taken from 3 different locations of the nebulizers of 102 patients.

Can the severity of erectile dysfunction be predicted by the change in plasma viscosity.

Background: We aimed to contribute to the literature by exploring the possible relationship of PV with erectile dysfunction (ED), as in atherosclerosis-based vascular diseases.

Methods: Between October 2021 and December 2022, 99 patients who applied to the urology polyclinic with a complaint of ED were included in the study (Group 1). Fifty-two patients who applied with a complaint other than ED constituted the control group (Group 2).

Can Sniff Nasal Inspiratory Pressure be a guide in detecting of sleep-disordered breathing in children with Duchenne Muscular Dystrophy?

Purpose: Duchenne muscular dystrophy (DMD) is a severe, progressive condition characterized by muscle degeneration and weakness, significantly affecting respiratory function. This study aimed to evaluate the presence of sleep-disordered breathing (SDB) in children with DMD and investigate the relationships between sleep and respiratory function using spirometry, sniff nasal inspiratory pressure (SNIP), and polysomnography (PSG) along with capnography.

Research Question: Can low SNIP be a guide for detecting respiratory muscle involvement early and determining the right time to perform early PSG and capnography in DMD?

Study Design: Prospective, observational, cross-sectional study.

Therapeutic vulnerabilities and pan-cancer landscape of BRAF class III mutations in epithelial solid tumors.

Background: Kinase-impaired class III BRAF mutations have recently received attention as a possible prognostic factor and therapeutic target. Class III BRAF variants differ from class I and class II mutations in terms of mechanism of pathway activation and therapeutic vulnerabilities. Genomic landscape analyses of tumors in large real-world cohorts represent a great opportunity to further characterize tumor-related molecular events and treatment vulnerabilities, however, such data is not yet available for tumors with BRAF class III mutations.

Associations between income level and health outcomes in people with cystic fibrosis in Turkey.

Background: Our study aimed to identify the social domains that pose the greatest barriers to managing and supporting pwCF, particularly in relation to income levels.

Methods: To identify associations between income and health outcomes in pwCF in our center the shorter form of the survey "Your Current Life Situation" (YCLS) was used in face-to-face interviews. Participants were also asked to complete the validated Turkish versions of the 9-item Patient Health Questionnaire (PHQ-9) and the 7-item Generalized Anxiety Disorder scale (GAD-7) to assess depression and anxiety, respectively.

A Neglected Point: Frailty in Older Adults with Differentiated Thyroid Cancer.

Backgruound: This study investigated the risk of frailty in older adults with differentiated thyroid cancer (DTC) and the effect of thyroid- stimulating hormone (TSH) levels on frailty.

Methods: This single-center, cross-sectional study included 70 DTC patients aged ≥60 years with stable TSH levels during the previous year while receiving levothyroxine. Frailty was assessed using the fried frailty phenotype (FFP).