Publications by authors named "Kuepper H"
Purpose: To evaluate the effect of different surface wear patterns on the discoloration tendency of two different prefabricated composite veneers and lithium disilicate ceramic veneers.
Materials And Methods: Discoloration tendency of two prefabricated composite resin veneers (Visalys Veneer Chairside (VIS) and Componeer (COM)) were compared to lithium disilicate veneers (IPS) in vitro. For each material, n = 60 samples were allocated to different test groups, and therefore each n = 10 specimens per group went through different wear tests.
Novel therapies for the treatment of acute myeloid leukemia (AML) are urgently needed, because current treatments do not cure most patients with AML. We report a domain-focused, kinome-wide CRISPR-Cas9 screening that identified protein kinase targets for the treatment of AML, which led to the identification of Rio-kinase 2 (RIOK2) as a potential novel target. Loss of RIOK2 led to a decrease in protein synthesis and to ribosomal instability followed by apoptosis in leukemic cells, but not in fibroblasts.
View Article and Find Full Text PDFPurpose: To measure surface roughness before and after wear-tests of two different prefabricated composite veneers and compare them to ceramic veneers and human dental enamel.
Materials And Methods: Roughness (Ra-values) of two prefabricated composite veneers (Visalys Veneer Chairside (VIS) and Componeer (COM)) were compared to lithium disilicate Veneers (e.max CAD) and dental enamel (DENT) in vitro.
Background: Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous disorder of the peripheral nervous system. Biallelic variants in have been associated with autosomal-recessive hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC). We identified heterozygous de novo variants in in three unrelated patients with intermediate CMT.
View Article and Find Full Text PDFPurpose: To investigate the pressure generated by different retraction materials using a novel gingival sulcus model.
Materials And Methods: A gingival sulcus model was made using a polymer frame filled with silicon. A pressure sensor and a sulcus-fluid simulation were embedded into the silicon chamber to evaluate the pressure generated by different retraction materials.
Objective: Does dental anxiety have an effect on dental and periodontal health?
Methods: Survey data was collected from n = 200 adults (53 % females, average age 49 years) in a cross-sectional study. Dental anxiety was measured with the modified dental anxiety scale (MDAS, score 1-5, the greater the score, the greater the anxiety). Clinical parameters including probing depth (PD), clinical attachment level (CAL), plaque index (SLI), and bleeding on probing (BoP) as well as the DMFT index were recorded and statistically analyzed.
Objectives: To investigate the effects, digital impression procedures can have on the three-dimensional fit of ceramic partial crowns in vitro.
Methods: An acrylic model of a mandibular first molar was prepared to receive a partial coverage all-ceramic crown (mesio-occlusal-distal inlay preparation with reduction of all cusps and rounded shoulder finish line of buccal wall). Digital impressions were taken using iTero (ITE), cara TRIOS (TRI), CEREC AC with Bluecam (CBC), and Lava COS (COS) systems, before restorations were designed and machined from lithium disilicate blanks.
Objective: A controlled clinical trial was conducted to evaluate the effects of oral prophylaxis on halitosis-associated, immunological and microbiological parameters.
Methods: Thirty subjects were included in this controlled clinical trial (patients with generalized chronic periodontitis and controls without clinical attachment loss; each n = 15). Before oral prophylaxis and 14 days after (including tongue cleaning) volatile sulphur compounds (VSC), organoleptic scores and a tongue coating index were evaluated.
Objectives: Machined restorations have been investigated for their preciseness before, while detailed information on the milling-step itself are lacking. Therefore, the aim of this laboratory study was to quantify the effect of a novel milling-procedure on the marginal and internal fit of ceramic restorations.
Methods: An acrylic model of a lower left first molar was prepared to receive a ceramic partial crown and was duplicated by one step dual viscosity impressions.
Objectives: A novel three-dimensional scanning technique was used to investigate the effects a one-step and a two-step impression methods can have on the three-dimensional fit of ceramic partial crowns.
Methods: An acrylic model of a mandibular first molar was prepared to receive a partial coverage all-ceramic crown (mesio-occlusal-distal inlay preparation with reduction of all cusps and rounded shoulder finish line of buccal wall). Type IV plaster replicates were cast based on one-step single viscosity (OS/SV), one-step dual viscosity (OS/DV), and two-step dual viscosity (TS/DV) impressions.
Statement Of Problem: The accuracy of impressions has been described in 1 or 2 dimensions, whereas it is most desirable to evaluate the accuracy of impressions spatially, in 3 dimensions.
Purpose: The purpose of this study was to demonstrate the accuracy and reproducibility of a 3-dimensional (3-D) approach to assessing impression preciseness and to quantitatively comparing the occlusal correctness of gypsum dies made with different impression materials.
Material And Methods: By using an aluminum replica of a maxillary molar, single-step dual viscosity impressions were made with 1 polyether/vinyl polysiloxane hybrid material (Identium), 1 vinyl polysiloxane (Panasil), and 1 polyether (Impregum) (n=5).
Objectives: The objective of this in vitro study was to visualize and to quantify the marginal and internal fit of heat-pressed ceramic restorations by a novel three-dimensional procedure. Accuracy and reproducibility of the employed measuring method were determined.
Methods: An acrylic model of a lower left first molar was prepared to receive a partial crown and duplicated by single step dual viscosity impressions.