Publications by authors named "Kuecuekukur Murat"

Article Synopsis
  • Dual antiplatelet therapy (DAPT) is essential for managing acute and chronic coronary syndromes, helping to lower mortality rates and prevent further complications.
  • A study followed 1500 patients on a specific fixed-dose DAPT (ASA + clopidogrel) to evaluate its effectiveness and safety, primarily focusing on hospitalization and bleeding risks.
  • Results indicated that the fixed-dose combination therapy was effective, with low rates of hospitalization for cardiovascular issues and minimal bleeding complications in appropriately selected patients.
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  • - A new scintillation material featuring InAs quantum dots in a GaAs matrix was developed and tested for its efficiency with various types of radiation.
  • - The research introduced a design methodology for an integrated photodetector with low defect density, optimizing its performance to match the quantum dot emission spectrum using a specialized buffer layer.
  • - Results showed the detector's electron yield for α-particles and photons, with alpha particles yielding 13 electrons/keV and photons yielding between 30-60 electrons/keV, alongside improved radiation hardness of InAs QDs in AlGaAs compared to those in GaAs.
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This study aimed to adopt the use of the Health Improvement Profile in the Turkish context and to report the findings obtained during its pilot implementation. This descriptive cross-sectional study consisted of 280 individuals, and data were collected using the Patient and Disease Characteristics Form and the Health Improvement Profile between May and December 2019 ın community mental health centers. The total content validity index of the Health Improvement Profile (Female-Male) was 0.

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Background: The one-minute sit-to-stand test (1STST) is an easy-to-administer, space and time-saving test for determining functional exercise capacity in cardiac disease. This study aimed to investigate the 1STST -test-retest reliability and convergent validity and compare its physiological responses to the six-minute walk test (6MWT) in patients with Atrial fibrillation (AF).

Methods: Forty-five patients with AF were included in this study.

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Advances in digital technology and intraoral scanners (IOSs) have the potential to enable accurate digital impressions for patients with maxillary defects. This study aimed to compare the accuracy of IOSs in completely and partially edentulous models with maxillary defects. Three polyurethane models-one completely edentulous (CE) and two partially edentulous, following Aramany classifications I (ACI) and II (ACII)-were created using stereolithography.

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Hepatitis C virus (HCV) is an important cause of chronic liver disease. Among at-risk populations, access to care is challenging. The French Ministry of Health has supported a seek-and-treat pilot intervention aiming at micro-elimination in Perpignan, France, to inform scale-up of elimination efforts across the whole territory.

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  • The war in Ukraine has led to changes in the types of injuries seen, particularly from high-energy weapons, necessitating new treatment methods for bone injuries.
  • A case study details the treatment of a 28-year-old man who suffered a severe fractured arm from a gunshot, using a 3D-printed polyetheretherketone scaffold to aid in healing.
  • The findings suggest that personalized treatment using advanced 3D printing technology for bone scaffolding can significantly improve recovery outcomes for patients with complex gunshot injuries.
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Background: Echocardiographic right ventricular (RV) dysfunction is a strong risk determinant for prognosis in patients with heart failure (HF). Although parameters of RV systolic function are widely used to define RV dysfunction, there is scarce data to suggest these parameters are best suited to predict HF-related outcomes.

Aims: We aimed to understand which morphologic or functional parameters are most closely associated with short-term mortality and HF-related hospitalization in patients with HF.

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Epitaxial quantum dot (QD) scintillator crystals with picosecond-scale timing and high light yield have been created for medical imaging, high energy physics and national security applications. Monolithic photodetector (PD) integration enables the sensing of photons generated within the waveguiding crystal and allows a wide range of scintillator-photodetector coupling geometries. Until recently, these doubly novel devices have suffered from complex, high variance responses to monoenergetic sources which significantly reduces their precision and accuracy.

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Aims: We aimed to determine the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and to identify clinical factors associated with their use in patients with heart failure (HF) in a real-life setting.

Methods: Real-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART study is a multicentre, cross-sectional and observational study that included HF patients in the outpatient setting regardless of ejection fraction from 19 cardiology centres between August 2023 and December 2023.

Results: The study population consisted of 1923 patients with HF, predominantly men (61.

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Objective: The aim of this study is to analyze the levels of nurses-patients interaction, as well as the humanistic practices in the field of nurse´s care.

Method: This cross-sectional and correlational study was conducted with 291 nurses in Istanbul between May-August 2022. The los datos were collected using the Personal Information Form, Caring Nurse-Patient Interaction-Short Form (CNPI), and Humanistic Practice Ability of Nursing (HPAN).

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Tumor-associated T cells orchestrate cancer rejection after checkpoint blockade immunotherapy. T cell function depends on dynamic antigen recognition through the T cell receptor (TCR) resulting in T cell activation. Here, we present an approach to quantify the dynamics and magnitude of tumor-associated T cell activation at multiple time points in living mice using the genetically encoded calcium reporter Salsa6f and functional intravital microscopy (F-IVM).

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  • The study evaluates the safety and effectiveness of controlled ovarian stimulation (COS) and oocyte retrieval (OR) in prepubertal and peripubertal patients who are seeking oocyte cryopreservation.
  • Researchers reviewed data from 20 patients aged approximately 15, assessing ovarian function through hormone levels and follicle counts, and found no complications related to the procedures.
  • Results showed a mean retrieval of 5 oocytes, with a maturation rate of 75%, and highlighted the positive relationship between antral follicle count and the number of retrieved oocytes.
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Neurons of the subpostremal nucleus of the solitary tract (NTS) respond to changes in extracellular glucose with alterations in membrane potential with both depolarization and hyperpolarization. From 5 mM glucose, a rapid shift to 0.5 mM glucose produces a membrane depolarization by an unknown mechanism in most neurons.

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In this study, we introduced a k-iterative double sliding-window (DSW^k) method for the estimation of spectral noise, signal-to-noise ratio (SNR), and baseline correction. The performance was evaluated using simulated spectra and compared against other commonly employed methods. Convergent evaluation determined that a k value of 20 strikes an optimal balance between convergence and computational intensity.

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Bilateral macronodular adrenocortical disease (BMAD) is an uncommon cause of Cushing's syndrome leading to bilateral macronodules. Isolated BMAD has been classified into three molecular groups: patients with ARMC5 alteration, KDM1A alteration, and patients without known genetic cause. The aim of this study was to identify by NGS, in a cohort of 26 patients with BMAD, the somatic alterations acquired in different nodules after macrodissection from patients with germline ARMC5 or KDM1A alterations and to analyze potential somatic alterations in a panel of five other genes involved in adrenal pathology (GNAS, PDE8B, PDE11A, PRKAR1A, and PRKACA).

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  • Posterior reversible encephalopathy syndrome (PRES) is a condition often associated with preeclampsia and eclampsia, characterized by brain swelling primarily in the parietal and occipital areas, but its exact causes are unclear.
  • A study of 213 patients revealed that 24.4% were diagnosed with PRES, with younger age and higher blood pressure significantly correlating with its development.
  • Key predictors for PRES included age, elevated blood pressure, and specific blood test results, suggesting that early imaging should be utilized for timely diagnosis in affected patients.
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Background: Although there have been significant improvements in the treatment of heart failure (HF) in recent decades, its prognosis remains poor. Although there are many biomarkers that can help predict the prognosis of patients with HF, there is a need for simpler, cheaper, and more easily available biomarkers.

Objective: To evaluate the predictive value of pan-immune-inflammation value (PIV) in patients with acute decompensated HF.

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  • The study aims to identify easily measurable biomarkers that reflect the biological effects of glucocorticoids in patients with Cushing's syndrome through whole blood transcriptome analysis.
  • It analyzed transcriptomic profiles from blood samples of different patient groups, creating a prediction model that effectively distinguishes between those with overt Cushing's syndrome and other conditions.
  • Findings indicate that the transcriptome can indicate glucocorticoid levels, with FKBP5 expression showing potential as a nonhormonal marker for diagnosing Cushing's syndrome.
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Aims: To examine the psychometric properties of the Stirling Antenatal Anxiety Scale (SAAS), developed by Sinesi et al., which assesses the level of anxiety of pregnant women in the prenatal period, in the Turkish culture, and to conduct a validity and reliability study.

Methods: This study had a methodological approach, with a cross-sectional and descriptive research design.

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Objective: This study assessed and compare the clinical and sonographic outcomes of extracorporeal shock wave therapy (ESWT) in patients with lateral epicondylitis (LE).

Methods: Forty-two LE patients were randomly divided into two groups: the ESWT group (n=21) and the sham-ESWT control group (n=21). Both groups underwent wrist resting splinting, stretching, strengthening exercises for wrist extensors, and ice application.

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