[Influence of ursodeoxycholic acid on the immune status of patients with cholesterosis of gall-bladder depending on cholesterol index in blood].

Application of ursodeoxycholic acid in a standard dosage for 3 months provided a positive effect in relation to the indexes of the immune system for patients with the cholesterosis of gall-bladder. It is shown that medicine assists renewal of T-cell immunity, renders positive influence on B-link and renewal of index of immunoregulation can be seen. Reliable increase of specific receptors to CD25, HLA-DR and high level of CD95 testifies about including of the scray reaction of organism under influence of ursodeoxycholic acid on the remaining high indexes of B-cell of immunity.

[Determination of the pancreatic inflammatory process activity in chronic pancreatitis].

There were 21 patients examined, who suffered chronic pancreatitis (CHP) in different activity of pancreatic inflammatory process. In the blood serum the contents of the inflammation markers was determined: tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10), ratio TNF-alpha/IL-10 was calculated, as well as activity of elastase in feces. Analysis of these indices permits to estimate the activity of pancreatic inflammatory process in patients, suffering CHP, what secures rising of the preoperative diagnosis and treatment efficacy, as well as reduction of intra- and postoperative complications rate.

[Beta-lactamases of clinical isolates of Enterobacteriaceae family].

Among 62 clinical strains of enterobacteria, isolated from intestinal tract, representatives of genus Escherichia made--67.4%, Klebsiella--4.84%, Citrobacter--4.

[Adipose tissue hormones and nutritional status in chronic obstructive pulmonary disease].

Aim: To study nutritional status in chronic obstructive pulmonary disease (COPD) in relation to the serum content of adipose tissue hormones.

Subjects And Methods: Ninety-four patients with Stages II and III COPD and 20 gender- and age-matched healthy non-smoking volunteers were examined. Interviews, analysis of laboratory data, enzyme immunoassay, and somatometry were made.

[Particular features of the relationship of Helicobacter pylori and G cells in patients with duodenal ulcer, with special reference to the Helicobacter pylori strain].

Helicobacter pylori positive form of duodenal ulcer (CagA+ and CagA-) was studied in 120 patients with duodenal ulcer (DU). CagA+ was found in 78 patients (65%); CagA(-)--in 42 (35%). Diagnostic criteria of symbiosis between Helicobacter pylori and macroorganisms have been established.

[The assessment of a state of tension in a pilot by bloodless biochemical and immunological study methods].

Immunological and biochemical study of salivary liquid was carried out in order to estimate the tensity state of a pilot in operating conditions. These studies were conducted in the period of flight-development tests during man-compartible estimation of the cockpit of a light aircraft. The existence of natrium and secretory "A"-immunoglobulin in saliva in combination with psychophysiological parameters of tensity made it possible to reveal different levels of tensity proliferation (slight, moderate, strong and very strong).

[The bacteriological and immunological efficacy of biosporin in nonspecific ulcerative colitis].

The results from examination of intestinal microflora and immune status in 75 patients with nonspecific ulcerative colitis with different degree of disease seriousness are presented. The deviations in the composition of normal microflora were primarily expressed in a decrease of the number of bifidobacteria. In 64.

[Role of individual genes in expression of phenotypic properties of the cold-adapted strain A/Leningrad/134/47/57 (H2N2)-a donor of attenuation of live influenza vaccine].

The influenza A/Leningrad/134/47/57 (H2N2) (A/Len/47) cold-adapted virus expresses the ability to reproduce at 25 degrees C (the ca phenotype) and inability to reproduce at 40 degrees C (the ts phenotype). It was attenuated for mice. Reassortants of this donor virus with the genes coding for the surface glycoproteins from the epidemic viruses, i.

[The role of immune links in the gastric acid-forming function in peptic ulcer patients].

Results are of a comparative analysis of immunological and biochemical parameters in 116 patients with duodenal ulcer before operative treatment and in the follow-up (1-3 years) after different types of vagotomy. A close relationship has been established between the immune and neurohumoral links of regulation and state of the acid forming gastric function in patients with ulcer disease.

[Enterosorption in the treatment of ulcerative colitis patients].

Enterodes and splenin were used in the treatment of patients with ulcerative colitis (idiopathic proctocolitis) in association with routine drug treatment while steroids were not employed. Results indicate increase of the therapeutic effect due to improvement of regeneration of the intestine and improvement of the immunity status.

[Mutations in the genes coding for hemagglutinin and neuraminidase in cold-adapted variants of the influenza virus A/Leningrad/134/57 (H2N2)].

An analysis of ts-mutations in the genomes of native and cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virus based on the use of fowl plague virus ts mutants was carried out. The recombination test was done by the conventional method in chick embryo fibroblast culture (genes PB2, PB1, PA, NP, NA, M and NS) or cell systems permissive for reproduction of human influenza virus (gene HA). The cold-adapted strain A/Len/17 used for preparation of live influenza vaccine (LIV) for adults was shown to have 4 ts mutations: three in "internal" genes (PB2, NP, and M) and one in gene 4 coding for hemagglutinin (HA).

[The pathomorphological changes in the brain and internal organs in experimental influenza infection in mice].

The possibility of long persistence of influenza virus A in the brain and other organs of mice was established on the basis of complex virological, histological and electron microscopic studies. It was shown that the perivascular oedema of choroid plexus reaches the maximum during late stages of infection, after the clinical recovery. Sharp increase of the permeability of cerebral vessels causing the perivascular oedema, especially in choroid plexus of lateral brain ventricles, proposed to be one of possible mechanisms of pathogenic action of the virus.

[Characteristics of immunologic status in patients with post-vagotomy disorders].

The results of examination of 578 patients with different postvagotomy disorders are presented. The patients with complete, incomplete and inadequate vagotomy were marked out. Among the postvagotomy disorders, the functional, organic and mixed ones were distinguished.

[Biological characteristics of epidemic and interepidemic strains of the influenza A (H3N2) virus].

Comparative studies of biological properties of influenza A (H3N2) viruses isolated in the epidemics of 1980 and 1983 and in the interepidemic period of 1982 showed a sharp reduction of the biological activity of the interepidemic viruses as compared with that of the epidemic ones. This was manifested by low isolation rate of virus in the interepidemic period, reduced hemagglutinating, interfering, and immunogenic activity of these viruses, poor reproduction in the lung tissue of white mice and the lack of virus-specific syntheses in splenocytes of infected Syrian hamsters. Unlike epidemic strains, the interepidemic strains had ts mutation in gene 6 coding for neuraminidase.

[Reproduction of the vesicular stomatitis virus in mouse splenocytes].

Interaction of vesicular stomatitis virus with immunocompetent cells in vivo and in vitro was studied. In intact mice, a prolonged infection of the spleens with low levels of virus replication was observed. Experiments with various splenocyte cultures demonstrated differences in their capacity to support virus reproduction.

[Changes in the biological properties of influenza virus (HON1) strains virulent for mice when exposed to homologous antibodies].

A decrease in the virulent properties of two influenza virus strains (A/PR/8/34 and A/Mel/35 (HON1) pathogenic for mice was demonstrated in multiple passages in chick embryos in the presence of homologous antibody. The artificially developed avirulent A/PR/8/240 and A/Mel/375 variants had low immunogenic activity and a marked temperature sensitivity to 40 degrees C. Common ts mutations in the genomes of these avirulent variants located in genes 1 and 7 coding for P3 and M proteins were demonstrated.

[Characteristics of the causative agents of the influenza A (H3N2) epidemic in Leningrad in 1983].

Investigation of influenza A (H3N2) epidemic of 1983 in Leningrad revealed simultaneous circulation of 3 antigenic variants similar to A/Bangkok/1/79, A/Bangkok/2/79, and A/Philippines/2/82 with significant predominance of the first antigenic variant. The viruses related to A/Philippines/2/82 comprising one-third of all isolations produced antibodies of a wide spectrum unlike the other two variants whose antisera neutralize actively the homologous virus only. The possibility of selecting epidemic strains of the A/Philippines/2/82 variety as vaccine strain candidates is discussed.

[Antigenic and biological characteristics of influenza A1 viruses isolated in the 1977 pandemic].

Investigations of the antigenic and biological properties of the causative agents of the 1977 influenza epidemic revealed their appurtenance to the old subtype A1 of influenza virus which had disappeared from circulation 20 years ago. A comparative study of A1 viruses isolated in 1947--1956 and A1/77 established closer relationship of the latter to the causative agents of 1949 and 1950 epidemics. The "old" and newly isolated viruses 4ere also closely related biologically.