Publications by authors named "Kubra Celik"
Article Synopsis
- Spinal Muscular Atrophy (SMA) is a genetic disease linked to the SMN1 gene that causes muscle weakness, with a carrier frequency of about 1 in 50 people and a prevalence of 1-3 per 10,000 live births.
- Turkey initiated the SMA Carrier Screening Program in 2021 to address increasing carrier rates, particularly due to consanguineous marriages, after noticing cases among children of healthcare workers who were unaware of screening options.
- A survey of 1,322 healthcare professionals revealed that 5.8% were unfamiliar with SMA and 26% lacked knowledge of the screening program, with significant gaps noted in secondary and tertiary professionals and non-physicians, indicating a need
A new electrochromic copolymer based on 4,7-di(thiophen-2-yl)benzo[c] [1,2,5]thiadiazole and 3,4-ethylenedioxythiophene was successfully obtained via the electrochemical polymerization method in the medium of electrolyte solution, which consists of 0.1 M tetrabutylammonium hexafluorophosphate and dichloromethane. In order to compare the electrochemical and chemical properties of the copolymer, the benzothiodiazole derivative and 3,4-ethylenedioxythiophene (EDOT) monomers, which are parts of the copolymer, are electrochemically polymerized, separately in the same environment and concentration with the copolymer.
View Article and Find Full Text PDFThere is still controversy over whether structural and morphological changes can be observed in tissues depending on the carbon dioxide (CO) nature or the applied intra-abdominal pressures (IAP). This study aimed to investigate the effects of different pressure or CO nature used for pneumoperitoneum in gynecological laparoscopic surgery on inflammation, DNA damage, oxidative stress, and histopathological changes in ovarian and peritoneal tissue. For this purpose, forty female rats were randomly divided into 6 groups and different pneumoperitoneum models were created in these groups.
View Article and Find Full Text PDFObjectives: The present study aimed to investigate the effects of acute hypoxia exposure following prenatal stress on the novelty-seeking behavior and hippocampus of adolescent rats.
Methods: The offspring were divided into prenatal stress (PS) and non-stress (NS) groups. Both groups were exposed to hypoxia on postnatal day 10 (P10) while control groups were undisturbed.
Article Synopsis
- - The study explores the characteristics of the SARS-CoV-2 virus, responsible for COVID-19, using Atomic Force Microscopy on different surfaces, specifically tissue culture polystyrene (TCPS) and glass coverslips.
- - Researchers drop cast SARS-CoV-2 onto these surfaces and examine its height profiles, density, and aggregation, noting a "coffee ring effect" where virions cluster near the edges of the drops, with a higher concentration on TCPS surfaces.
- - The effects of ethanol disinfectant on the virus were also analyzed to assess its impact on SARS-CoV-2, providing insights into the ultrastructure of the virus after treatment.
Background: We have limited knowledge about the effects of antipsychotic exposure on the development of gestational diabetes mellitus (GDM). Aim of this study is to perform a systematic review and meta-analysis to assess GDM risk associated with antipsychotic exposure in pregnancy.
Methods: Systematic literature search was performed using PubMed, Science Direct, Scopus, and Web of Science databases up to August 22, 2018.
Article Synopsis
- - Evidence indicates that low levels of vitamin D (25-OH vitamin D) might elevate the risk of various cardiovascular diseases, including hypertension and heart failure.
- - A study examined the relationship between vitamin D levels and coronary atherosclerosis, finding that individuals with atherosclerosis had significantly lower vitamin D levels compared to healthy controls.
- - While low vitamin D levels were linked to increased plaque burden in coronary atherosclerosis, no significant correlation was found between vitamin D levels and the structure or morphology of the plaques.
In this study, the cytotoxic, genotoxic/antigenotoxic and antioxidant/oxidant activity of copaene (COP), a plant-derived tricyclic sesquiterpene, on human lymphocyte cultures (n = 5) was investigated. COP was added into culture tubes at various concentrations (0, 10, 25, 50, 100, 200 and 400 mg/L). While the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays were used for viability and cytotoxic evaluations, the micronucleus (MN) and sister chromatid exchange (SCE) assays were used for genetic evaluations.
View Article and Find Full Text PDFThe purpose of this study was to evaluate the effect of carotenoid astaxanthin (ASTA) on cultured primary rat hepatocytes treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the cell viability (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, MTT), lactate dehydrogenase (LDH) activity, 8-oxo-2-deoxyguanosine (8-OH-dG), total antioxidant capacity (TAC), and total oxidative stress (TOS) levels, and liver micronucleus rates. ASTA (2.5, 5, and 10 µM) was added to cultures alone or simultaneously with TCDD (5 and 10 µM) for 48 h.
View Article and Find Full Text PDFThe most potent of the dioxins, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is a persistent and ubiquitous environmental contaminant. And the health impact of exposure to TCDD is of great concern to the general public. Recent data indicate that L-glutamine (Gln) has antioxidant properties and may influence hepatotoxicity.
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