Parathyroid imaging by (18)F-fluorocholine PET/CT in patients with primary hyperparathyroidism and inconclusive conventional methods: clinico-pathological correlations.

(18)F-fluorocholine positron emission tomography/computed tomography (FCH) was performed after inconclusive neck ultrasound and (99)Tc-sestaMIBI SPECT (MIBI) scintigraphy in patients with primary hyperparathyroidism (PHPT) to localize abnormal parathyroid glands before surgery. The results were retrospectively evaluated and compared to postoperative histopathological findings. 13 patients with PHPT were enrolled (mean age 64.

Is fluorine-18-fluorocholine PET/CT suitable for the detection of skeletal involvement of multiple myeloma?

Our limited experience suggests that fluorine-18-fluorocholine (F-FCH) may perform better in the detection of skeletal involvement by multiple myeloma compared to fluorine-18-fluorodeoxyglucose (F-FDG) and that standard uptake ratio (SUR) might be considered in the semi-quantitative comparison of tracer uptake.

Alternating R-CHOP and R-cytarabine is a safe and effective regimen for transplant-ineligible patients with a newly diagnosed mantle cell lymphoma.

Implementation of cytarabine into induction therapy became standard of care for younger patients with mantle cell lymphoma (MCL). On the basis of its beneficial impact, many centers incorporated cytarabine at lower doses also into first-line treatments of elderly patients. We conducted a multicenter observational study that prospectively analyzed safety and efficacy of alternating 3 + 3 cycles of R-CHOP and R-cytarabine for newly diagnosed transplant-ineligible MCL patients.

Parathyroid Carcinoma in Patients that Have Undergone Surgery for Primary Hyperparathyroidism.

Background/aim: Parathyroid carcinoma is a rare clinical entity, which represents one of the main reasons, why surgery should be performed in specialized centres. Preoperatively, it is very difficult to distinguish between benign and malignant hyperparathyroidism.

Patients And Methods: During the years 1996-2016, we performed 2,220 operations in 2,075 patients with a diagnosis of primary hyperparathyroidism.

[Isolated Perfusion of the Upper Extremity with TNF-α - Double Venous Cannulation].

Background: The authors present a technical variation of the standard cannulation for cardiopulmonary bypass perfusion during hyperthermic isolated limb perfusion (ILP) procedures in selected patients with unresectable soft tissue sarcoma or malignant melanoma.

Patients: Of 55 ILP procedures performed at our institution since the procedure was established in 2009, nine were performed at the upper extremity. Standard single venous cannulation was used in five cases, and extended, double venous cannulation in the last four.

Measurement of intact parathormone during operation for primary hyperparathyroidism.

In this prospective study, the role of the intact parathormone (iPHT) levels for the verification of pathologic parathyroid tissue removal during parathyroidectomy, was analyzed in 441 patients diagnosed with primary hyperparathyroidism. The level of intact parathormone was obtained before the initial incision (baseline level) and 10 minutes after the pathologic parathyroid gland removal (control value). In 80 % of cases, the decrease of intact parathormone was more than 50 % of the baseline level.

[Hyperthermic Isolated Limb Perfusion Combined with Tasonermin - a Perfusion Leakage Monitoring Technique].

Background: Hyperthermic isolated limb perfusion is used to treat irresectable extremity malignancies. It is based on the following principle - the perfusion of the extremity is isolated from systemic circulation and connected to an extra-corporal circuit via which a very high concentration of a chemotherapeutic agent is administered into the blood compartment of the extremity. In some cases, treatment efficiency can be improved using tasonermin (a TNF-α agent).

[Videothoracoscopic excision of mediastinal parathyroid adenoma in primary hyperparathyroidism].

Introduction: Primary hyperparathyroidism is a disease caused by elevated secretion of parathyroid hormone from pathological parathyroid glands. After the diagnosis, the success of its surgical solution depends predominantly on surgical management and experience of the surgeons. A special group is formed by ectopic localizations of pathologically enlarged parathyroid glands in the mediastinum, which require a modified surgical approach.

[Hypercalcemia, symptoms, differential diagnostics and treatment, or importance of calcium investigation].

Unlabelled: The concentration of calcium is carefully maintained under physiological conditions with parathormone, calcitonin and 1,25-dihydroxyvitamin D at appropriate levels. There are multiple causes that may bring about increased concentrations of calcium which exceed physiological values. Increased production of parathormone in parathyroid glands is only one of the possible causes.

Comparison of planar DMSA scan with an evaluation based on SPECT imaging in the split renal function assessment.

Background: Validation of the 99mTc-DMSA planar scintigraphy accuracy for split renal function assessment and comparison with evaluation based on SPECT imaging both with and without CT attenuation correction.

Materials And Methods: For split renal function assessment two methods were used: A) planar scintigraphy based on anterior and posterior projections using correction for kidney depth calculated by the geometric mean; B) semi-quantitative evaluation based on SPECT (B1) and attenuation-corrected SPECT/CT (B2) images using locally developed software for kidney segmentation and voxel-based analysis. All three methods were performed with a phantom simulating body including pair of kidneys.

Biochemical Testing After Pheochromocytoma Removal: How Early?

Pheochromocytomas are catecholamine-producing tumors with typical clinical presentation. Tumor resection is considered as an appropriate treatment strategy. Due to its unpredictable clinical behavior, biochemical testing is mandatory to confirm the success of tumor removal after surgery.

Changes in the Pattern of Primary Hyperparathyroidism in Czech Republic.

Primary hyperparathyroidism (PHPT) is currently the most common endocrine disorder in Czech Republic after diabetes and thyroid diseases particularly in postmenopausal women. Over the past 40 years PHPT has changed from a rare severe disease of the bones and kidneys to common disease with hypertension, peptic ulcer, pancreatitis, easy fatigue and proximal muscle weakness. During 43 years we have examined one of the greatest groups of patients with PHPT.

[Ectopic parathyroid glands. Imaging methods and surgical access].

We discuss the benefits of imaging methods in localizing ectopic parathyroid glands in patients with primary hyperparathyroidism. The ectopic localizations are discussed within the context of the orthotopic norm. In the sample of 123 patients, a 23% rate of ectopic parathyroid glands was detected.

The role of 99mTc-MIBI SPECT/low dose CT with 3D subtraction in patients with secondary hyperparathyroidism due to chronic kidney disease.

Objective: The aim of the present work was to assess the incidence of parathyroid glands hyperplasia or adenoma in patients with various stages of chronic renal insufficiency using 99mTc-methoxyisobutylisonitrile (MIBI) SPECT and 3D subtraction technique with 99mTc-pertechnetate (Tc).

Subjects And Methods: Sixty one patients underwent hybrid SPECT with low-dose CT of the parathyroid glands and thyroid SPECT scintigraphy. Thirty six patients were with chronic kidney disease (CKD) without renal failure (RF) and 25 patients underwent peritoneal dialysis or hemodialysis.

[Repeated surgery for parathyroid carcinoma].

Introduction: Carcinoma of the parathyroid glands is a rare cause of primary hyperparathyroidism with an incidence of 1%.

Material And Methods: This article presents an up-to-date review of the literature illustrated by three clinical cases in the form of case reports.

Results: Parathyroid carcinoma is usually not detected before the first operation.

High incidence of cardiovascular complications in pheochromocytoma.

Excess of catecholamines in pheochromocytoma is usually accompanied with classical symptoms and signs. In some cases, severe cardiovascular complications (e. g.

[Radioiodine 131I therapy of hyperthyroidism on an outpatient basis - safe, effective and economic option].

Introduction: Radioiodine 131I therapy of hyperthyroidism on an outpatient basis is widely accepted over the world. In Czech Republic, however, radioiodine therapy is still not enough used, and has been realized on an inpatient basis to date. Our work is the first analysis of the experiences with radioiodine therapy of hyperthyroidism on an outpatient basis in Czech Republic.

V/P scan in diagnosis and follow-up of pulmonary embolism in 15-25-year-old females in relation to hormonal contraception use.

Background: An analysis of medical records of young females who were examined in our department during a five-year period (2005-2009) on suspicion of pulmonary embolism (PE) in relation to hormonal contraception (HC).

Material And Methods: The patient sample included 86 young females aged 15-25 (mean 21) years who underwent a ventilation/ perfusion scintigraphy (V/P scan). Seventeen of them were examined repeatedly.

[Surgical therapy of primary hyperparathyrodism in the context of orthopaedic diagnosis and treatment: our experiences in 441 patients].

Purpose Of The Study: Primary hyperparathyroidism is an endocrine disorder affecting calcium and phosphate metabolism. It is surgically treated by removing hyperfunctional parathyroid tissue. The aim of the study was to show, based on surgical results, that the introduction of serum calcium screening in orthopaedic therapy is effective.

Improvement of hypertension after parathyroidectomy of patients suffering from primary hyperparathyroidism.

Background. Primary hyperparathyroidism (PHPT) is one of the most common endocrine conditions and is accompanied by hypertension and increased cardiovascular mortality. The purpose of this study was to evaluate the effect of parathyroidectomy on systolic and diastolic blood pressure (BP) in hypertensive patients with PHPT and whether hypertension occurs more frequently in PHPT than in control group.

[Therapy of thyroid carcinoma using radioiodine].

The paper is submitted as one of the recommendations for diagnostic and therapeutic care in nuclear medicine meant in particular for the clinical need of physicians indication treatment of thyroid carcinoma with iodide. The author presents a brief review of principles, indications, the procedure proper, clinical interpretation and possible risks and contraindications, incl. the clinical and socioeconomic impact.

[Palliative therapy of bone metastases using radiopharmaceuticals. Recommendations for diagnostic and therapeutic care in nuclear medicine].

The paper is presented as one of recommendations of diagnostic and therapeutic care in the field of nuclear medicine intended especially for the clinical needs of physicians indicating palliative treatment of metastases into bones using radiopharmaceuticals. It provides a brief review of principles, indications, the very performance of interventions, clinical interpretations, possible risks and contraindications including the clinical and social-economic meaning.

[Scintigraphic diagnosis of abscesses and other inflammatory processes using indium 111In labeled leukocytes].

Autologous polymorphonuclear leucocytes are injected after separation and labelling with 111In oxine to the patient with a suspect inflammatory process and after 24 hours their localization is assessed by standard scintigraphic examination by a scintillation camera. The authors examined in a prospective investigation 33 patients--the sensitivity of the method was in that group 80%, the specificity 100%, the diagnostic accuracy 94%. The authors discuss the possibilities of application of the method in intraperitoneal abscesses and in some inflammations with another localization.

[Role of cerclage in the prevention of abortion and premature labor].

In the course of the analysis of the results of 175 cerclage-operations carried out during the last 5 years, the authors intended to answer the question: whether the operation is reasonable on the basis of a prophylactic indication. As indication of this kind has been considered for example the following: when in the case-history of the patient one or more spontaneous abortions have occured after the third month of gravidity--with insufficient symptoms, when the mother's birth was a full-term confinement after cerclage-operation, finally, when the insufficiency of the cervical os had been diagnosed before getting pregnant. At symptoms of incipient abortion the aim of the medical treatment was therapeutic.