Ruxolitinib for Hemophagocytic Lymphohistiocytosis in Multiple Myeloma: Case Report and Review of the Literature.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare complication of multiple myeloma (MM), with limited data available on its incidence, clinical presentation, and treatment. The underlying mechanisms linking MM and HLH remain unclear, including the potential role of MM treatment agents in triggering HLH.

Methods: This case report presents a patient with MM who developed HLH while on lenalidomide maintenance therapy.

The Effect of Training Experience on Cardiac Morphology in Resistance Exercise Practitioners: A Study on Left Ventricular Systolic and Diastolic Parameters and Left Atrium Mechanical Functions.

: Resistance exercises (REs) are a type of physical activity that individuals from many age groups have been doing recreationally, both as amateurs and professionally, in their daily lives in recent years. It is crucial to understand the effects of such sports on cardiac morphology in order to maximize the benefit of training and to tailor the training content accordingly. The aim of this study was to investigate the relationship between training experience (TE) and left ventricular (LV) systolic and diastolic parameters and left atrial (LA) mechanical function in healthy subjects who regularly performed RE for different durations.

Assessment of ipsilateral and contralateral perfusion after contrast compression therapy of upper limb muscles in MMA athletes - a cross-over study.

Objective: The primary aim of this study was to compare the immediate effect of contrast compression therapy with the use of Game Ready (GRT) on hyperaemic reactions in the upper limb on the application and contralateral sides, specifically in the context of mixed martial arts (MMA) athletes.

Design: In this experimental, single-blind, randomized crossover study, we recruited 30 male volunteers training in MMA (mean age: 28.33 ± 3.

The impact of the "treasure game" on geometric thinking and post-learning mood in first-grade children.

Background: This study aimed to investigate the effect of the motor game "Treasure Game" (TG) on first-grade children's level of geometric thinking and post-learning mood tracking (PLMT).

Methods: The study employed 24 first-grade children aged 6.1 ± 0.

Depressor Labii Inferioris Muscle Palsy After Chin Augmentation.

The depressor labii inferioris (DLI) muscle helps to lower and turn the lower lip outward and receives innervation from the marginal mandibular branch of the facial nerve. Paralysis of this muscle is a rare but potential complication of chin augmentation injections. Paralysis of the DLI causes symptoms such as difficulty smiling on the affected side, difficulty speaking clearly, and facial asymmetry, especially when smiling.

Metamorphosis of a unicellular green alga in the presence of acetate and a spatially structured three-dimensional environment.

Photosynthetic protists, named microalgae, are key players in global primary production. The green microalga Chlamydomonas reinhardtii is a well-studied model organism. In nature, it dwells in acetate-rich paddy rice soil, which is not mimicked by standard liquid laboratory conditions.

Medical Students' Views on Their Experience of Applying to Research Ethics Committees: A Qualitative Study.

The scope of medical training has expanded to encompass clinical skills and the ability to conduct and interpret scientific research. Therefore, medical students must develop an awareness of research and publication ethics to advance in their careers. This study aimed to understand medical students' perceptions of their first encounter with a research ethics committee.

Immediate and Long-Term Effects of Breathing Exercises on Reaction Time.

: The aim of this study was to investigate the immediate and long-term effects of breathing exercises on simple and choice reaction time. : A total of 31 participants were included in the study. The participants were randomly divided into two groups.

Ethics in Pediatric Decision-Making and Application Process: A Clinical Perspective.

Decision-making capacity in pediatric health care is crucial for upholding ethical practices and protecting patient autonomy. It involves a patient's ability to understand the benefits, risks, and alternatives of a proposed treatment or intervention, demonstrate understanding, appreciate the consequences, reason clearly, and communicate their wishes. Informed consent and assent are essential concepts in pediatric decision-making, ensuring that patients, including children, clearly understand their treatment options, and voluntarily agree to them.

Determining the appropriate concentration of an anesthetic mixture in three different fish species with the PROMETHEE decision model.

Anesthesia is applied to protect fish welfare for reducing employee workload in aquaculture. The efficacy of the anesthetic agent varies depending on the fish species. In this study, the effect of a commercial anesthetic (VetiVital AquaSED) manufactured mainly with herbal extracts (includes eugenol, linalool, linalyl acetat etc.

Survival Outcomes of Patients with Primary Plasma Cell Leukemia in the Era of Proteasome Inhibitors and Immunomodulatory Agents: A Real-Life Multicenter Analysis.

Objective: In this study, we aimed to obtain real-life data on the use of antimyeloma agents, which significantly increase overall survival (OS) in multiple myeloma (MM) patients, in primary plasma cell leukemia (pPCL) patients with poor prognosis.

Materials And Methods: Data from 53 patients who were diagnosed with pPCL between 2011 and 2020 and who used at least one proteasome inhibitor (PI) and/or immunomodulatory (IMID) agent were analyzed retrospectively. Depending on the year of the pPCL diagnosis, 20% leukocytes or ≥2x10/L plasma cells in the peripheral blood was used as a diagnostic criterion.

The prognostic significance of modified frailty index-5 in patients undergoing pneumonectomy for lung cancer.

Objectives: In some centrally located lung cancers, complete excision of the mass cannot be achieved with parenchymal-sparing procedures and pneumonectomy may be required. The mortality and morbidity rates of pneumonectomy were reported to be considerably high. Here, we investigated the effectivity of modified frailty index-5 (MFI-5) in patients undergoing pneumonectomy for non-small cell lung cancer.

Prognostic Evaluation of Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and Hematological Indices in Classic Hodgkin Lymphoma.

Introduction: Hodgkin lymphoma (HL) constitutes 10% of all lymphoma diagnoses and accounts for 5% of lymphoma-related deaths. Accurate prognostication in HL remains crucial, particularly given that 10%-20% of patients may receive either insufficient or excessive treatment. This study investigates the effect of hemoglobin, albumin, lymphocyte, and platelet (HALP) score, which is a marker of inflammation status and nutrition, at the time of diagnosis for the patients with HL on prognosis.

Good laboratory practice for PGT-M: Turkish Society of Reproductive Medicine guidelines.

This guideline was prepared by the Turkish Society of Reproductive Medicine to define the conditions and requirements for an outsourced preimplantation genetic testing (PGT) programme in line with the experience and needs of practitioners. This guideline is intended to be a reference document for assisted reproductive technology centres, genetic diagnosis centres, non-governmental organizations working on reproductive health, legal experts, consultants working on laboratory accreditation, academicians specializing in ethical issues, and policy makers. The Consortium aims to provide recommendations addressing the challenges of genetic testing, especially PGT for monogenic diseases (PGT-M) due to the high rate of consanguineous marriage in Turkey.

Impact of extracorporeal hemadsorption on mortality in critically ill COVID-19 patients in the intensive care unit.

Background: The consequences of COVID-19, such as respiratory failure and mortality, require the search for fast and effective solutions. The aim of this retrospective study is to determine the effect of extracorporeal hemadsorption on mortality in severe COVID-19 cases hospitalized in the intensive care unit (ICU).

Methods: Our study is retrospective, single-center, and observational.

Antibiotic Resistance Profiles of Escherichia coli and Salmonella spp. Isolated From Dairy Farms and Surroundings in a Rural Area of Western Anatolia, Turkey.

Background Antibiotic resistance is a significant public health issue worldwide. Antibiotic-resistant zoonotic bacteria such as (), , , , , and can be particularly isolated from biofertilizers. Epidemiological studies have shown that cases of foodborne infections and intoxications are significantly related to animal-derived foods.

The Role of Self-Compassion and Social Anxiety in the Relationship Between Cognitive Distortions and Emotional Eating.

This study aimed to examine the mediating role of self-compassion and social anxiety in the relationship between cognitive distortions and emotional eating. The research was carried out on 406 adult individuals between the ages of 18-25 living in different regions of Turkey. To measure research variables, Liebowitz social anxiety, thought types, self-sensitivity, and Turkish emotional eating scale were used.

Dietary salt concentrations influence growth, nutrient utilization, and fatty acid profiles of turbot (Scophthalmus maximus) reared in brackish water.

Expansion of economically viable turbot (Scophthalmus maximus) aquaculture depends on access to brackish-cold ground water sources in various parts of the world. Since brackish water sources can adversely affect the physiology and zoo technical performance of fish due to the burden of osmoregulation, dietary salt inclusion can alleviate the negative impacts of low-saline waters in several aquaculture species. This study investigated the effects of increasing dietary salt levels on the growth, feed utilization, body composition, and tissue fatty acid composition of juvenile turbot (initial live weight 120.

Does the Effect of Mental Fatigue Created by Motor Imagery on Upper Extremity Functions Change with Diaphragmatic Breathing Exercises? A Randomized, Controlled, Single-Blinded Trial.

: This study focused on the impact of mental fatigue induced by motor imagery on upper limb function, an area with limited research compared to lower limb performance. It aimed to explore how diaphragmatic breathing exercises influence these effects. : This study included 30 participants, and Group 1 participated in 12 sessions of diaphragmatic breathing exercises under the supervision of a physiotherapist; Group 2 did not receive any intervention.

Human gender estimation from CT images of skull using deep feature selection and feature fusion.

This research endeavors to prognosticate gender by harnessing the potential of skull computed tomography (CT) images, given the seminal role of gender identification in the realm of identification. The study encompasses a corpus of CT images of cranial structures derived from 218 male and 203 female subjects, constituting a total cohort of 421 individuals within the age bracket of 25 to 65 years. Employing deep learning, a prominent subset of machine learning algorithms, the study deploys convolutional neural network (CNN) models to excavate profound attributes inherent in the skull CT images.

Chronotype as a predictor of athletic performance in youth with mild intellectual disabilities.

Aim: This study aimed to explore the influence of circadian rhythms on athletic performance in individuals with mild intellectual disabilities (ID), with a specific focus on elucidating the association between chronotype and various performance metrics.

Methods: The study was a cross-sectional study consisting of 30 male participants aged between 11 and 19 years and diagnosed with mild ID. The chronotypes of all participants were assessed using the Childhood Chronotype Questionnaire (CCQ).