PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum.

Thoracic ossification of the ligamentum flavum (TOLF) is a heterotopic ossification of spinal ligaments, leading to serious myelopathy. TOLF underlying mechanisms are not well understood. Our iTRAQ analysis have identified ten inflammatory factors related to TOLF, including l.

Polyester Nanofiltration Membranes for Efficient Cations Separation.

Polyester nanofiltration membranes highlight beneficial chlorine resistance, but their loose structures and negative charge result in poor cations retention precluding advanced use in cations separation. This work designs a new monomer (TET) containing "hydroxyl-ammonium" entities that confer dense structures and positive charge to polyester nanofiltration membranes. The TET monomer undergoes efficient interfacial polymerization with the trimesoyl chloride (TMC) monomer, and the resultant TET-TMC membranes feature one of the lowest molecular weight cut-offs (389 Da) and the highest zeta potential (4 mv, pH: 7) among all polyester nanofiltration membranes.

Identification of kaempferol as an OSX upregulator by network pharmacology-based analysis of qianggu Capsule for osteoporosis.

Osteoporosis is the most common metabolic disease of skeleton with reduced bone density and weaker bone. Qianggu Capsule as a traditional chinese medicine has been widely used to treat osteoporosis. The potential pharmacological mechanism of its active ingredient Gusuibu is not well understood.

Exploring the Pharmacological Mechanism of Duhuo Jisheng Decoction in Treating Osteoporosis Based on Network Pharmacology.

Objective: The purpose of this work is to study the mechanism of action of Duhuo Jisheng Decoction (DHJSD) in the treatment of osteoporosis based on the methods of bioinformatics and network pharmacology.

Methods: In this study, the active compounds of each medicinal ingredient of DHJSD and their corresponding targets were obtained from TCMSP database. Osteoporosis was treated as search query in GeneCards, MalaCards, DisGeNET, Therapeutic Target Database (TTD), Comparative Toxicogenomics Database (CTD), and OMIM databases to obtain disease-related genes.

A Nature-Inspired Monolithic Integrated Cellulose Aerogel-Based Evaporator for Efficient Solar Desalination.

Solar-driven seawater desalination is a prospective approach to tackle the problem of freshwater shortage. Establishing a robust, efficient solar-thermal water evaporator with great salt-resistance through a facile and scalable fabrication technique is still a challenge. In this study, a floatable and robust monolithic integrated cellulose aerogel-based evaporator (MiCAE) with high performance is fabricated by carefully designing and integrating three functional components, namely, a hydrophilic cellulose-PVA aerogel (CPA), hydrophobic silylated cellulose aerogel (SCA), and multiwalled carbon nanotube (MCNT) coating layer (CPA@CNT), through the heterogeneous mixing and freeze-drying aerogel fabrication step in situ.