Publications by authors named "Kuankuan Li"
Background: The challenge in treating irreversible nerve tissue damage has resulted in suboptimal outcomes for spinal cord injuries (SCI), underscoring the critical need for innovative treatment strategies to offer hope to patients.
Methods: In this study, gelatin methacrylic acid hydrogel scaffolds loaded with nerve growth factors (GMNF) were prepared and used to verify the performance of SCI. The physicochemical and biological properties of the GMNF were tested.
Article Synopsis
- The study evaluated the effectiveness and safety of percutaneous endoscopic interlaminar discectomy (PEID) for high-grade migrated lumbar disc herniation (LDH) in 328 patients.
- Results showed no significant differences in hospitalization, surgery time, or complications between high-grade and low-grade groups, but both groups experienced significant improvement in pain and disability scores post-surgery.
- Overall, PEID demonstrated favorable outcomes for high-grade migrated disc herniation with benefits like less trauma and quicker recovery, achieving a 94.7% rate of successful results.
Article Synopsis
- Dysregulation of extracellular matrix metabolism in nucleus pulposus (NP) cells is a key feature of intervertebral disc degeneration (IDD), with the study focusing on the role of Testis expressed 11 (ZIP4) in this process.
- The study utilized interleukin-1β (IL-1β) and other treatments to model IDD in NP cells, measuring various molecular changes and levels of several proteins associated with inflammation and oxidative stress.
- Results showed that increased ZIP4 levels in NP cells contribute to inflammation and ECM degradation by activating pathways involving HDAC4 and NF-κB, suggesting that ZIP4 plays a critical role in the progression of IDD.
Correlation between spinal cord stimulation analgesia and cortical dynamics in pain management.
Ann Clin Transl Neurol
January 2024
Aim: Spinal cord stimulation (SCS) is an effective method to treat neuropathic pain. It is necessary to identify the responders of SCS analgesia before implantation. The aim of this study is to investigate the relationship between the cortical dynamics and SCS analgesia responders in pain management.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness and safety of combining immune checkpoint inhibitors with chemotherapy or chemoradiotherapy in treating locally advanced esophageal cancer, comparing it to traditional neoadjuvant strategies.
- A meta-analysis of eight trials involving 652 patients showed that neoadjuvant immunotherapy results in a higher pathological complete response (pCR) and major pathological response (MPR) rates compared to routine neoadjuvant therapy.
- However, there was no significant difference in the surgical resection rates between the neoadjuvant immunotherapy and routine therapy groups.
There are two most widely used transthoracic esophagectomy methods: the McKeown Minimally Invasive esophagectomy (McKeown MIE) and the Sweet Esophagectomy. We evaluated and compared the therapeutic effects of these two methods to determine the appropriate method for the treatment of middle and lower third esophageal cancer patients who received neoadjuvant chemotherapy combined with immunotherapy (NACI). We retrospectively analyzed 43 sweet esophagectomy cases received NACI and 167 cases with McKeown MIE in the fourth hospital of Hebei Medical University from December 2019 to May 2022.
View Article and Find Full Text PDFBackground: At present, the clinical conclusion that robotic-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS), which is better for patients with non-small cell lung cancer (NSCLC) is not clear. Therefore, this meta-analysis aimed to compare the perioperative outcomes between RATS and VATS for NSCLC.
Methods: The Population, Interventions, Comparators, Outcomes, and Study design (PICOS) framework was employed to develop the search strategy, and the findings was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
Solving the issue of infection associated with implanted bone substitutes is one of the modern challenges of the biomedical engineering field. The purpose of this study was to develop a novel porous scaffold with sufficient antibacterial activity for bone repair or regeneration. Porous nanohydroxyapatite/polyurethane (n-HA/PU) composite scaffolds containing different amounts of silver phosphate particles were prepared through the in situ foaming method.
View Article and Find Full Text PDF