Publications by authors named "Kuang-Yu Chao"
Article Synopsis
- - Chuanminshen violaceum (CV) is used in traditional medicine to improve lung function, aid digestion, reduce phlegm, and detoxify, with its active polysaccharides not thoroughly understood from its stems and leaves.
- - This study aimed to optimize the extraction of polysaccharides from CV using ultrasound, analyze their structure, and evaluate their anti-inflammatory and antioxidant properties with a focus on their mechanisms of action.
- - Researchers successfully isolated a polysaccharide (CVP-AP-I) that was primarily pectic, demonstrated a molecular weight of 35.34 kDa, and showed potential in reducing inflammation and oxidative stress in intestinal cells following exposure to LPS.
Article Synopsis
- - A new cryoprotectant-gel composite (CGC) was developed to protect cartilage tissue during frozen osteoarticular autograft reconstruction in high-grade sarcoma cases, and its effectiveness was tested in rat and pig models.
- - The CGC showed superior protective capabilities, preserving cartilage integrity and reducing cell death compared to freezing alone or using a standard liquid cryoprotectant; it maintained more proteoglycans and led to fewer apoptotic chondrocytes.
- - This research suggests that using a high concentration of CGC during the freezing process could be a promising strategy for preserving articular cartilage in surgeries for malignant bone tumors. !
Background: Liquid nitrogen (LN) has been used as an adjuvant cryotherapy for bone tumors including giant-cell tumor of the bone (GCTB) to remove residual tumor cells after curettage. This study evaluated variables related to the efficacy of LN-based cryoablation in the context of adjuvant treatment of GCTB using porcine femur bone model.
Methods: A porcine femur bone model was adopted to simulate intralesional cryotherapy.
Biological reconstruction of allografts and recycled autografts have been widely implemented in high-grade osteogenic sarcoma. For treating tumor-bearing autografts, extracorporeal irradiation (ECIR) and liquid nitrogen (LN) freezing techniques are being used worldwide as a gold standard treatment procedure. Both the methods aim to eradicate the tumor cells from the local recurrence and restore the limb function.
View Article and Find Full Text PDFCell therapies using human mesenchymal stem cells (MSCs) have received much attention in the past decade. In pursuit of the therapeutic potential of MSCs, cell expansion is required to generate a great number of cells with desired phenotype and functionality. Long-term expansion in vitro, however, can lead to altered functions.
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