Publications by authors named "Kuang Zhong-Sheng"
[Study on molecular target of Taohong Siwu Decoction in delaying growth of fibroblasts based on network pharmacology].
Zhongguo Zhong Yao Za Zhi
September 2020
Article Synopsis
- Taohong Siwu Decoction (THSWD) is a traditional Chinese medicine that may help improve blood circulation and combat renal fibrosis, particularly in cases of IgA nephropathy (IgAN), although the exact mechanism isn’t fully understood.
- Researchers used network pharmacology to identify 61 active ingredients and 240 targets in THSWD, focusing on the role of the ERK factor in relation to IgAN fibrosis.
- Experimental results indicated that THSWD significantly reduced the activity of fibroblasts by lowering ERK1/2 mRNA and phosphorylated ERK1/2 protein levels, suggesting its potential as a treatment option for delaying fibrosis progression.
Objective: To observe the effects of beta-asarone on the morphology and cell viability in PC12 cells and cultured neonate rat cortical neurons.
Methods: The cultured neonate rat cortical neurocytes were stained immunocytochemically with NSE, GFAP antibodies, respectively; Morphological changes were observed under phase contrast microscope after PC12 cells and cultured rat cortical neurons with beta-asarone of different concentrationfor 24h in vitro, and the cell viability of PC12 and cortical neurons were examined by MTT assay.
Results: Most of the cultured neonate rat cortical neurocytes were positively stained with NSE antibody, and positively with GFAP in a less degree; Treatment of PC12 cells with concentrations of 7.
The aim of the study was to assess the prevalence of human papillomavirus (HPV) in the esophagus in the coastal region of Eastern Guangdong, Southern China, an area with a high incidence of esophageal carcinoma. Fresh surgical resection esophageal specimens were obtained from 176 esophageal carcinoma patients admitted to the Tumor Hospital of Shantou University Medical College. The samples were subjected to polymerase chain reaction (PCR) to detect HPV infection using consensus and type-specific primers for HPV type 6, 11, 16, and 18.
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