Stability analysis of existing tunnels under dynamic loads during excavation of new tunnels.

Understanding the deformation mechanism and behaviour of adjacent tunnels subjected to dynamic train loads provides vital technical insights for engineering design. This study conducted a detailed analysis and revealed that tunnel excavation significantly affects the stability of adjacent existing tunnels under dynamic loads. First, we developed a dynamic load simulation approach and derived a calculation formula for shield-soil friction.

Analysis of cultivated land degradation in southern China: diagnostics, drivers, and restoration solutions.

Introduction: Cultivated land quality degradation is a critical challenge to food security, requiring effective nature-based restoration strategies based on comprehensive assessments of land quality. However, existing methods are often costly, limited in scope, and fail to capture the multidimensional complexity of the degradation processes.

Methods: This study integrated vegetation indices, topographic data, and soil physical and chemical properties to construct a model for identifying cultivated land degradation.

Decoding xenia effects on 'Jinsha' pomelo: Insights from physiological, transcriptomics and metabolomics analyses.

'Xenia' is the terminology and biology of direct, or immediate, pollen effects on seeds and fruits. In this study, we found that the pollination of 'Jinsha' pomelo (JS) with pollen from Grapefruit (GR) and 'Majia' pomelo (MJ) led to significant differences in the seed numbers and primary metabolite (soluble sugar and amino acid). In pollinated pistils, the differences in the number of pollen tubes entering the embryo sac and the content of cytokinin components at 5 d post-pollination between the two pollen sources might be the important factor contributing to the discrepancies of seed trait and further affected fruit quality.

LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis.

Osteoarthritis (OA) is a degenerative disease which places an enormous burden on society, effective treatments are still limited. As a non-invasive and safe physical therapy, low-intensity pulsed ultrasound (LIPUS) can alleviate OA progression, but the underlying mechanism is not fully understood, especially the mechanical transduction between LIPUS and the organism. In this pioneering study, the biomechanical effects of LIPUS on living mice chondrocytes and living body zebrafish are investigate by using fluorescence imaging technology, to dynamically "visualize" its invisible mechanical stimuli in the form of calcium oscillations.

OTFS Radar Waveform Design Based on Information Theory.

In this work, we consider the waveform design for radar systems based on orthogonal time-frequency space (OTFS). The conditional mutual information (CMI), chosen as a promising metric for assessing the radar cognitive capability, serves as the criterion for OTFS waveform design. After formulating the OTFS waveform design problem based on maximizing CMI, we propose an equivalent waveform processing approach by minimizing the autocorrelation sidelobes and cross-correlations (ASaCC) of the OTFS transmitting matrix.

Effect of Photoperiod on Ascorbic Acid Metabolism Regulation and Accumulation in Rapeseed ( L.) Seedlings.

Ascorbic acid (AsA) is an important antioxidant for human health. The concept of "oil-vegetable-duel-purpose" can significantly enhance the economic benefits of the rapeseed industry. Rapeseed, when utilized as a vegetable, serves as a valuable food source of AsA.

Association between Blood Trihalomethane Concentrations and the Risk of Dyslipidemia: Nationally Representative Cross-Sectional Study.

Experimental studies have indicated that exposure to disinfection byproducts (DBPs) may affect the lipid synthesis. However, epidemiological evidence is sparse. This study aimed to investigate the relationship between blood trihalomethane (THM) exposure and the risk of dyslipidemia from the National Health and Nutrition Examination Survey 2005-2018.

Comparative transcriptomics of indica and japonica rice roots under heat stress reveals the crucial role of OsMAPK3 in heat response.

Heat stress is one of the most critical environmental factors impacting rice cultivation, driven by the rising global temperatures. Therefore, understanding the differences in molecular mechanisms of heat stress tolerance between rice cultivars, particularly indica and japonica, is crucial for developing heat-tolerant varieties. In this study, high throughput RNA-sequencing technology was utilized to explore the transcriptomic changes in the root tissues of two rice varieties, 93-11 (indica) and ZH11 (japonica) under heat stress and during recovery.

The Scoring Model to Predict ICU Stay and Mortality After Emergency Admissions in Atrial Fibrillation: A Retrospective Study of 30 366 Patients.

Background: The rapid assessment of the conditions is crucial for the prognosis of atrial fibrillation (AF) patients admitted to the emergency department (ED). We aim to derive and validate a more accurate and simplified scoring model to optimize the triage of AF patients in the ED.

Materials And Methods: We conducted a retrospective study using data from the Medical Information Mart for Intensive Care (MIMIC-IV) database and developed scoring models employing the Random Forest algorithm.

Burden of respiratory tract cancers in China and its provinces, 1990-2021: a systematic analysis of the Global Burden of Disease Study 2021.

Background: Respiratory tract cancers emerged as a public health challenge with the highest incidence and mortality among all cancer types in China, despite many national policies in place, such as early cancer screening. It is of outmost importance to monitor the burden of respiratory tract cancers across China and its provinces for refining health strategies.

Methods: Based on Global Burden of Disease (GBD) estimates, the present study investigated the age-sex specific pattern alterations of incidence, prevalence, mortality, and disability adjusted life years (DALYs) of respiratory tract cancers in China from 1990 to 2021, as well as its Estimated Annual Percentage Change (EAPC), Age-Standardized Incidence Rate (ASIR), and Age-Standardized Mortality Rate (ASMR).

Brucella bloodstream infection mimicking systemic juvenile idiopathic arthritis: a pediatric case report.

Background: Systemic juvenile idiopathic arthritis (sJIA) accompanied with Brucella bloodstream and bone marrow infection is an exceedingly rare occurrence in clinical practice. Owing to the striking similarity in their clinical presentations, there is a propensity for misdiagnosis or underdiagnosis.

Case Presentation: In this case, the pediatric patient underwent medical treatment across five different hospitals over a three-month period before receiving an accurate diagnosis and successful treatment.

Extracellular vesicles in tumor immunity: mechanisms and novel insights.

Extracellular vesicles (EVs), nanoscale vesicles secreted by cells, have attracted considerable attention in recent years due to their role in tumor immunomodulation. These vesicles facilitate intercellular communication by transporting proteins, nucleic acids, and other biologically active substances, and they exhibit a dual role in tumor development and immune evasion mechanisms. Specifically, EVs can assist tumor cells in evading immune surveillance and attack by impairing immune cell function or modulating immunosuppressive pathways, thereby promoting tumor progression and metastasis.

Risk assessment of hyperbilirubinemia using a three-factor model after cardiac surgery.

Background: Hyperbilirubinemia (HB) is a common occurrence after cardiopulmonary bypass and often results in increased rates of complications.

Methods: We conducted a study on 411 patients who underwent cardiac surgery with extracorporeal circulation and divided them into a training set and a validation set. Least absolute shrinkage and selection operator (LASSO) regression was employed to screen out variables.

Integrated Transcriptomics and Metabolomics Analysis Reveals Convergent and Divergent Key Molecular Networks of Dominant Genic Male Sterility and Cytoplasmic Male Sterility in Cabbage.

Cytoplasmic male sterility (CMS) and dominant genic male sterility (DGMS) both result in the inability to produce or release functional pollen, making them pivotal systems in the hybridization breeding programs of crops such as cabbage ( var. ). However, the underling molecular mechanisms are still largely unexplored.

Dynamic Manipulation of Ice Nucleation by an Electrochemical Reaction.

In this report, we present a simple and effective method for manipulating ice nucleation through an electric-field-induced electrochemical reaction. By applying an electric field strength of 2 kV/m on water between a tin anode and platinum cathode, a significant increase of 7 °C in the nucleation temperature of water was observed. This threshold electric field strength is considerably lower than those reported in previous studies on electro-freezing.

An alternative splicing caused by a natural variation in BnaC02.VTE4 gene affects vitamin E and glucosinolate content in rapeseed (Brassica napus L.).

Vitamin E (VE) is essential for plants and animals. Rapeseed oil is rich in α-tocopherol (α-T), which is the most bioactive form of VE in human body. This study demonstrated that VE in rapeseed seeds was mainly controlled by embryo genotype through incomplete diallel hybridization.

Identification of the BBX gene family in blueberry at different chromosome ploidy levels and fruit development and response under stress.

Background: Blueberry (Vaccinium spp.) fruits are rich in flavonoids such as anthocyanins and have a high nutritional value. The zinc finger protein transcription factor B-box (BBX) plays important roles in plant growth and development, hormone response, abiotic stress, and anthocyanin accumulation.

Differentiation of genome-wide DNA methylation between japonica and indica rice.

Rice (Oryza sativa L.) subspecies japonica and indica show distinct morphological and genetic differentiation. However, the differences in the genome-wide DNA methylation and its effects on gene expression and metabolic levels between japonica and indica rice remain unclear.

Takeaway food consumption and depressive symptoms in Chinese university students: mediating effects of physical activity.

Background: The consumption of takeaways is becoming increasingly prevalent. Despite this, the relationship between takeaway food consumption and depressive symptoms in Chinese populations has not been clarified. Furthermore, the factors that mediate the association between takeaway frequency and depressive symptoms are unknown.

Retinal Phenotypes and Single-cell Sequencing Analysis of Ush2a Knockout Mice.

Usher syndrome is a rare autosomal recessive genetic disorder that primarily affects both vision and hearing, manifesting as sensorineural hearing loss and progressive vision loss caused by retinitis pigmentosa. The pathogenesis of retinal degeneration in Usher syndrome is still largely unknown. In this study, a novel Ush2a knockout mouse model was successfully constructed using CRISPR/Cas9 technology.

Antibiotic susceptibility and molecular characterization based on whole-genome sequencing of Staphylococcus aureus causing invasive infection in children and women living in Southwest China during 2018-2023.

Background: Staphylococcus aureus is one of the most common pathogens that colonizes human skin/mucous membranes, where it causes local infection that can progress to invasive infection, resulting in high morbidity and mortality worldwide. This study aimed to investigate the antibiotic susceptibility and molecular characteristics of invasive S. aureus in children and women in Southwest China from 2018 to 2023 to provide novel insights helpful in preventing and treating S.

Early Identification of the Non-Transplanted Functional High-Risk Multiple Myeloma: Insights from a Predictive Nomogram.

: Patients with multiple myeloma (MM) who have a suboptimal response to induction therapy or early relapse are classified as functional high-risk (FHR) patients and have been shown to have a dismal prognosis. The aim of this study was to establish a predictive nomogram for patients with non-transplanted FHR MM. : The group comprised 215 patients in our center between 1 January 2006 and 1 March 2024.

Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway.

Lycopene is a natural plant extract widely studied for its powerful antioxidant and neuroprotective effects. Emerging evidence suggests that it also possesses potential antidepressant properties. Compared to commonly used clinical antidepressants, lycopene offers higher safety; however, its underlying mechanisms remain unclear.

L1CAM extracellular vesicles derived from the serum of adolescents with major depressive disorder induce depression-like phenotypes in adolescent mice.

Background: It has been reported that L1 cell adhesion molecule (L1CAM) antibody can capture neuron-derived extracellular vesicles (NDEVs) derived from peripheral blood. This antibody is significantly associated with occurrence of adult psychiatric disorders. However, the role and mechanism of L1CAM EVs (L1 EVs) in adolescent with major depressive disorder (AMDD) is not well understood.

Higher magnesium depletion score increases the risk of all‑cause and cardiovascular mortality in US adults with diabetes.

Background: Both dietary magnesium and serum magnesium are associated with the prognosis of diabetic patients. However, the impact of the magnesium depletion score (MDS), which assesses systemic magnesium deficiency, on the prognosis of diabetic patients remains unclear. This cohort study aims to explore the potential association between the MDS and all-cause and cardiovascular mortality in diabetic patients.