Prediction of municipal waste generation using multi-expression programming for circular economy: a data-driven approach.

The existing surge in municipal waste generation (MWG), characterized by swiftly changing and uncontrollable factors, poses a significant challenge to sustainable development. This prompted the need for improved predictive models to guide strategic waste management within the circular economy framework. This study aims to develop a predictive model using multi-expression programming (MEP) to assess MWG.

Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis.

Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent cause of liver disease worldwide, with a single approved therapeutic. Previous research has shown that interleukin-22 (IL-22) can suppress β-cell stress, reduce local islet inflammation, restore appropriate insulin production, reverse hyperglycemia, and ameliorate insulin resistance in preclinical models of diabetes. In clinical trials long-acting forms of IL-22 have led to increased proliferation in the skin and intestine, where the IL-22RA1 receptor is highly expressed.

The oral health landscape in Singapore: A commentary on key features, challenges and future policies.

Over the last decade, Singapore has grappled with substantial healthcare challenges, chiefly a bourgeoning aging population and a mounting burden of chronic diseases. The oral health landscape has also changed, with the Ministry of Health placing a greater focus on a life-course approach supported by policies that facilitate Singaporeans to receive dental care appropriately and affordably. A pivotal oral health policy is the National Dental Strategy, a comprehensive framework governing dental services in the public sector.

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells.

Major histocompatibility complex (MHC) II is dynamically expressed on mucosal epithelial cells and is induced in response to inflammation and parasitic infections, upon exposure to microbiota, and is increased in chronic inflammatory diseases. However, the regulation of epithelial cell-specific MHC II during homeostasis is yet to be explored. We discovered a novel role for IL-22 in suppressing epithelial cell MHC II partially via the regulation of endoplasmic reticulum (ER) stress, using animals lacking the interleukin-22-receptor (IL-22RA1), primary human and murine intestinal and respiratory organoids, and murine models of respiratory virus infection or with intestinal epithelial cell defects.

MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier.

Background & Aims: MUC13 cell surface mucin is highly expressed on the mucosal surface throughout the intestine, yet its role against bacterial infection is unknown. We investigated how MUC13 impacts Salmonella typhimurium (S Tm) infection and elucidated its mechanisms of action.

Methods: Muc13 and wild-type littermate mice were gavaged with 2 isogenic strains of S Tm after pre-conditioning with streptomycin.

Three-dimensional analysis of the interchangeability of a semiadjustable articulator system in service over time.

Statement Of Problem: Some contemporary articulator systems claim to be highly precise in their interchangeability, with tolerances below 10 μm in vertical error; however, the claims have not been independently verified.

Purpose: The purpose of this study was to investigate the interchangeability of calibrated semiadjustable articulators in service over time.

Material And Methods: A calibrated mounting articulator served as the master articulator, while the test groups were used articulators with a minimum of 1-year use by predoctoral dental students (n=10); used articulators with a minimum of 1-year use by prosthodontic residents (n=10); and new articulators (n=10).

Wildlife resource conservation and utilization for achieving sustainable development in China: main barriers and problem identification.

The rapid growth of the industrial economy has affected the survival of wildlife, and the decline in wildlife resources will in turn have some negative impact on the industrial economy. For the sustainable development of the industrial economy, human beings began to reflect on traditional development thinking and strive to find a development strategy that harmonizes industrial economic development and resource protection, and wildlife protection gradually attracted people's attention. "Protecting wild animals, maintaining ecological balance, and promoting economic development" has become a hot topic in the new century.

Production planning approaches: a review from green perspective.

There is an increasing concern about incorporating green criteria into production planning approaches. Production planning models that ignore green parameters may generate outcomes that are unfriendly to the environment. The relevant literature has suggested a flourishing trend towards the integration of green parameters into production planning approaches.

IL-20 Activates ERK1/2 and Suppresses Splicing of X-Box Protein-1 in Intestinal Epithelial Cells but Does Not Improve Pathology in Acute or Chronic Models of Colitis.

The cytokine Interleukin (IL)-20 belongs to the IL-10 superfamily. IL-20 levels are reported to increase in the intestines of Ulcerative Colitis (UC) patients, however not much is known about its effects on intestinal epithelial cells. Here, we investigated the influence of IL-20 on intestinal epithelial cell lines and primary intestinal organoid cultures.

Endolysins against Streptococci as an antibiotic alternative.

Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively researched in different fields, including medicine, food, and agricultural applications.

Status of sustainable manufacturing practices: literature review and trends of triple bottom-line-based sustainability assessment methodologies.

Due to significant requirement of energy, water, material, and other resources, the manufacturing industries significantly impact environmental, economic, and social dimensions of sustainability (triple bottom-line). In response, today's research is focused on finding solution towards sustainable manufacturing. In this regard, sustainability assessment is an essential strategy.

MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Cancer via Activating the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Axis.

Background & Aims: MUC1 is abnormally expressed in colorectal cancer, including colitis-associated colorectal cancer (CAC), but its role in tumorigenesis is unclear. This study investigated MUC1's effects in murine models of colitis and CAC and elucidated mechanisms of action.

Methods: Colitis and CAC were induced in mice by exposure to dextran sodium sulfate or azoxymethane plus dextran sodium sulphate.

Waste heat recovery research - a systematic bibliometric analysis (1991 to 2020).

Human usage of non-renewable energy resources has caused many environmental issues, which include air pollution, global warming, and climate irregularities. To counter these issues, researchers have been seeking after alternative renewable energy sources and ways to manage energy more efficiently. This is where energy recovery technologies such as waste heat recovery (WHR) come into play.

A hybrid decision-making framework to manage occupational stress in project-based organizations.

According to recent studies in the field of human resource management (HRM), especially in project-based organizations (PBOs), stress is recognized as a factor that has a paramount significance on the performance of staff. Previous studies in organizational stress management have mainly focused on identifying job stressors and their effects on organizations. Contrary to the previous studies, this paper aims to propose a comprehensive decision-support system that includes identifying stressors, assessing organizational stress levels, and providing solutions to improve the performance of the organization.

An integrated approach for a sustainable supplier selection based on Industry 4.0 concept.

The recent advances in sustainable supply chain management are integrated with Industry 4.0 concepts. This study develops a new integrated model to consider the sustainability and Industry 4.

Three-dimensional positional accuracy of intraoral and laboratory implant scan bodies.

Statement Of Problem: In the implant digital workflow, scan bodies provide the 3D position of digital implants in the virtual dental arch. However, limited evidence is available on scan body accuracy, selection, and usage.

Purpose: The purpose of this in vitro study was to evaluate the 3D positional accuracy of 4 intraoral and 6 laboratory scan body systems to the implants and laboratory replicas of an implant system under various torque magnitudes.

K-Ras Peptide Mimotope Induces Antigen Specific Th1 and B-Cell Immune Responses against G12A-Mutated K-Ras Antigen in Balb/c Mice.

G12A somatic point mutation in adenocarcinomas is categorized clinically as ineligibility criteria for anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapies. In this study, a modified G12A-K-ras epitope (139A) with sequence-specific modifications to improve immunogenicity was developed as a potential vaccine against G12A-mutant cancers. Additionally, coupling of the 139A epitope with a tetanus toxoid (TTD) universal T-cell epitope to improve antigenicity was also reported.

Gut microbiota shape the inflammatory response in mice with an epithelial defect.

Intestinal epithelial cell endoplasmic reticulum (ER) stress has been implicated in intestinal inflammation. It remains unclear whether ER stress is an initiator of or a response to inflammation. mice, carrying a gene mutation resulting in intestinal goblet cell ER stress, develop spontaneous colitis with a depleted mucus barrier and increased bacterial translocation.

A hyper-hybrid fuzzy decision-making framework for the sustainable-resilient supplier selection problem: a case study of Malaysian Palm oil industry.

One of the major challenges of the supply chain managers is to select the best suppliers among all possible ones for their business. Although the research on the supplier selection with regards to green, sustainability or resiliency criteria has been contributed by many papers, simultaneous consideration of these criteria in a fuzzy environment is rarely studied. Hence, this study proposes a fuzzy decision framework to investigate the sustainable-resilient supplier selection problem for a real case study of palm oil industry in Malaysia.

pH - Responsive colloidal carriers assembled from β-lactoglobulin and Epsilon poly-L-lysine for oral drug delivery.

Site specific oral delivery of many biopharmaceutical classification system (BCS) class II and IV drugs is challenging due to their poor solubility, low permeability and degradation in the gastrointestinal tract. Whilst colloidal carriers have been used to improve the bioavailability of such drugs, most nanocarriers based drug delivery systems suffer from multiple disadvantages, including low encapsulation efficiency (liposomes, polymeric nanoparticles), complex synthesis methods (silica, silicon-based materials) and poorly understood biodegradability (inorganic nanoparticles). Herein, a novel pH responsive nanocolloids were self-assembled using natural compounds such as bovine β-lactoglobulin (BLG) and succinylated β-lactoglobulin (succ.

Oral Delivery of β-Lactoglobulin-Nanosphere-Encapsulated Resveratrol Alleviates Inflammation in Winnie Mice with Spontaneous Ulcerative Colitis.

Resveratrol (RES) is a nutraceutical with promising anti-inflammatory properties for the treatment of inflammatory bowel diseases (IBD). However, the clinical effectiveness of resveratrol as an oral anti-inflammatory agent is hindered by its extremely poor solubility and poor stability. In this study, we encapsulated resveratrol in β-lactoglobulin (BLG) nanospheres and systematically analyzed their formulation parameters followed by a thorough anti-inflammatory testing in a highly specialized spontaneous murine UC model (Winnie mice model).

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity.

Many adenocarcinomas, including colorectal cancer (CRC), overexpress the MUC13 cell surface mucin, but the functional significance and mechanisms are unknown. Here, we report the roles of MUC13 in colonic tumorigenesis and tumor progression. High-MUC13 expression is associated with poor survival in two independent patient cohorts.

Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles.

Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubility and low permeability which reduces its clinical potential especially when given orally. Packaging of drugs within ordered mesoporous silica nanoparticles (MSNs) is an emerging strategy for increasing drug solubility and permeability of BCS (Biopharmaceutical Classification System) class II and IV drugs.