S100A8 promotes tumor progression by inducing phenotypic polarization of microglia through the TLR4/IL-10 signaling pathway in glioma.

Background: S100A8 is a member of the S100 protein family and plays a pivotal role in regulating inflammation and tumor progression. This study aimed to comprehensively assess the expression patterns and functional roles of S100A8 in glioma progression.

Methods: Glioma tissues were collected from 98 patients who underwent surgical treatment at Fudan University Shanghai Cancer Center.

Metabolomic Profiling Reveals Biomarkers in Coronary Heart Disease Comorbidity.

Coronary heart disease (CHD), hypertension (HTN), depression (Dep), and Type 2 diabetes mellitus (T2DM) are often comorbid, resulting in an exacerbated patient condition and worsened prognosis. A lack of systematic metabolomic studies on comorbidities of CHD remains. Therefore, comprehensive metabolomic-based evaluation of comorbidities of CHD is necessary.

Investigating ocular biomarkers and differential diagnosis of Alzheimer's disease and vascular cognitive impairment based on multimodal imaging.

Significance: The eye can be used as a potential monitoring window for screening, diagnosis, and monitoring of neurological diseases. Alzheimer's disease (AD) and vascular cognitive impairment (VCI) are common causes of cognitive impairment and may share many similarities in ocular signs. Multimodal ophthalmic imaging is a technology to quantify pupillary light reaction, retinal reflectance spectrum, and hemodynamics.

Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Demonstrates That Sleep Disorders Exacerbate Glymphatic Circulatory Impairment and Cognitive Impairment in Patients with Alzheimer's Disease.

Objective: Sleep disorders are common in Alzheimer's disease (AD) patients and can impair the glymphatic system, leading to cognitive decline. This study aimed to investigate whether AD patients with sleep disorders exhibit worse glymphatic function and more severe cognitive impairment compared to those without sleep disorders and to explore the underlying molecular imaging mechanisms.

Methods: This study included 40 AD patients with sleep disorders (ADSD), 39 cognitively matched AD patients without sleep disorders (ADNSD), and 25 healthy middle-aged and elderly controls (NC).

Nanotechnology for the Diagnosis and Treatment of Liver Cancer.

Liver cancer has become a major global health challenge due to its high incidence, high rate of late diagnosis and limited treatment options. Although there are many clinical treatments available for liver cancer, the cure rate is still very low, and now researchers have begun to explore new aspects of liver cancer treatment, and nanotechnology has shown great potential for improving diagnostic accuracy and therapeutic efficacy and is therefore a promising treatment option. In diagnosis, nanomaterials such as gold nanoparticles, magnetic nanoparticles, and silver nanoparticles can realize highly sensitive and specific detection of liver cancer biomarkers, supporting diagnosis and real-time monitoring of the disease process.

Innovative public strategies in response to COVID-19: A review of practices from China.

The COVID-19 pandemic presented unparalleled challenges to prompt and adaptive responses from nations worldwide. This review examines China's multifaceted approach to the crisis, focusing on five key areas of response: infrastructure and system design, medical care and treatment, disease prevention and control, economic and social resilience, and China's engagement in global health. This review demonstrates the effectiveness of a top-down command system at the national level, intersectoral coordination, a legal framework, and public social governance.

Advances in research on the impact and mechanisms of pathogenic microorganism infections on pyroptosis.

Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death characterized by the activation of gasdermin proteins, leading to the formation of pores in the cell membrane, continuous cell swelling, and eventual membrane rupture. This process results in the release of intracellular contents, including pro-inflammatory cytokines like IL-1β and IL-18, which subsequently trigger a robust inflammatory response. This process is a crucial component of the body's innate immune response and plays a significant role in combating infections.

Predicting microbe-disease associations via graph neural network and contrastive learning.

In the contemporary field of life sciences, researchers have gradually recognized the critical role of microbes in maintaining human health. However, traditional biological experimental methods for validating the association between microbes and diseases are both time-consuming and costly. Therefore, developing effective computational methods to predict potential associations between microbes and diseases is an important and urgent task.

Role of a new inflammation predictor in predicting recurrence of atrial fibrillation after radiofrequency catheter ablation.

Background: Radiofrequency catheter ablation (RFCA) has become an important strategy for treating atrial fibrillation (AF), and postoperative recurrence represents a significant and actively discussed clinical concern. The recurrence after RFCA is considered closely related to inflammation. Systemic immune inflammation index (SII) is a novel inflammation predictor based on neutrophils, platelets, and lymphocytes, and is considered a biomarker that comprehensively reflects the immune inflammatory status of the body.

Self-Management of Kidney Transplant Recipients Research: A Comprehensive Bibliometric Analysis.

Objective: This study analyzes research trends in self-management among kidney transplant recipients to inform future directions.

Methods: Bibliometric analysis was performed on 444 English articles related to self-management of kidney transplant recipients in the Core Collection of Web of Science and Scopus databases using COOC 12.8, R software, Microsoft Excel 2019, VOSviewer, and CiteSpace, with a focus on citation ranking, publication year, journal, country, organization, author, impact factor, and keywords.

Immunogenicity of Short-Course, High-Dose Hepatitis B Vaccination in Patients with Chronic Kidney Disease - Shanxi Province, China, 2019-2020.

What Is Already Known About This Topic?: As one of the populations at high risk of hepatitis B virus (HBV) infection, patients with chronic kidney disease (CKD) require rapid and effective development of hepatitis B surface antibodies (anti-HBs).

What Is Added By This Report?: The short-course, high-dose regimen of hepatitis B vaccination rapidly induced comparable immunological responses to the routine regimen, achieving a seroconversion rate of 88.5%, a high-response rate of 64.

Mechanically Stable and Damage Resistant Freestanding Ultrathin Silver Nanowire Films with Closely Packed Crossed-Lamellar Structure.

One-dimensional (1D) functional nanowires are widely used as nanoscale building blocks for assembling advanced nanodevices due to their unique functionalities. However, previous research has mainly focused on nanowire functionality, while neglecting the structural stability and damage resistance of nanowire assemblies, which are critical for the long-term operation of nanodevices. Biomaterials achieve excellent mechanical stability and damage resistance through sophisticated structural design.

Deep Learning-Based Automated Optical Inspection System for the Additive Manufacturing of Diamond Tools.

Cutting tools with orderly arranged diamond grits using additive manufacturing show better sharpness and longer service life than traditional diamond tools. A retractable needle jig with vacuum negative pressure was used to absorb and place grits in an orderly arranged manner. However, needle hole wear after a long service time could not promise complete grit adsorption forever.

Analysis of outcomes in resected early-stage NSCLC with rare targetable driver mutations.

Background: Given advancements in adjuvant treatments for non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK)-targeted therapies, it is important to consider postoperative targeted therapies for other early-stage oncogene-addicted NSCLC. Exploring baseline outcomes for early-stage NSCLC with these rare mutations is crucial.

Objectives: This study aims to assess relapse-free survival (RFS) and overall survival (OS) in patients with resected early-stage NSCLC with rare targetable driver mutations.

Hydrogel microspheres for bone regeneration through regulation of the regenerative microenvironment.

Bone defects are a prevalent category of skeletal tissue disorders in clinical practice, with a range of pathogenic factors and frequently suboptimal clinical treatment effects. In bone regeneration of bone defects, the bone regeneration microenvironment-composed of physiological, chemical, and physical components-is the core element that dynamically coordinates to promote bone regeneration. In recent years, medical biomaterials with bioactivity and functional tunability have been widely researched upon and applied in the fields of tissue replacement/regeneration, and remodelling of organ structure and function.

Methane mitigation potentials and related costs of China's coal mines.

Mitigating methane (CH) emissions from China's coal mines as the largest contributor to anthropogenic CH emissions is vital for limiting global warming. However, the knowledge about CH mitigation potentials and economic costs of Chinese coal mines remain poorly understood, which hinders the formulation of tailored CH mitigation strategies. Here, we estimate and project China's provincial coal mine methane (CMM) emissions, mitigation potentials and costs under various coal production scenarios, by integrating the dynamic emission factors of CMM and key abatement technologies.

Current status and future of hepato-pancreatico-biliary surgery fellowship training in China.

The medical education system, particularly the fellowship training system, of China has been continuously developing and improving. China established the fellowship training system in 2016, with the period for general surgeons being 3 years. Among the various general surgery subspecialties, hepatopancreatobiliary (HPB) surgery has a specialized training period of approximately 6 months.

[Genetic analysis of children with nonsyndromic sensorineural hearing loss due to novel mutations/deletions of bialleles].

To investigate the clinical and genetic characteristics of nonsyndromic sensorineural hearing loss caused by biallelic variation. A child with hearing impairment who was diagnosed at Gansu Provincial Maternal and Child Health Hospital on May 2022 and was selected as the research object. Peripheral blood of the child and her parents was collected, genomic DNA was extracted.

DeepTGIN: a novel hybrid multimodal approach using transformers and graph isomorphism networks for protein-ligand binding affinity prediction.

Predicting protein-ligand binding affinity is essential for understanding protein-ligand interactions and advancing drug discovery. Recent research has demonstrated the advantages of sequence-based models and graph-based models. In this study, we present a novel hybrid multimodal approach, DeepTGIN, which integrates transformers and graph isomorphism networks to predict protein-ligand binding affinity.

Investigation of the safety of position-based titanium plate fixation for costal cartilage injuries.

Background: Costal cartilage injuries are unappreciated, and there is a paucity of reports on fixation methods. This study aims to evaluate the safety of titanium plate internal fixation for costal cartilage injuries.

Methods: A retrospective analysis was conducted on 30 patients with costal cartilage injuries who underwent titanium plate internal fixation between April 2016 and November 2022 at our hospital.

Effects of dimethylarsenate coprecipitation with ferrihydrite on Fe(II)-induced mineral transformation and the release of dimethylarsenate.

Organoarsenicals are toxic pollutants of global concern, and their environmental geochemical behavior might be greatly controlled by iron (Fe) (hydr)oxides through coprecipitation, which is rarely investigated. Here, the effects of the incorporation of dimethylarsenate (DMAs(V)), a typical organoarsenical, into the ferrihydrite (Fh) structure on the mineral physicochemical properties and Fe(II)-induced phase transformation of DMAs(V)-Fh coprecipitates with As/Fe molar ratios up to 0.0876 ± 0.

Basigin in cerebrovascular diseases: roles, mechanisms, and therapeutic target potential.

Cerebrovascular diseases are major global health issues, responsible for significant morbidity and mortality. Basigin (additionally called CD147 or EMMPRIN) is a glycosylated transmembrane protein that facilitates intercellular communication. Recent research has highlighted the critical role of Basigin in inducing matrix metalloproteinases (MMPs), which contribute to the progression of cerebrovascular diseases.

Multi-omics reveals the mechanism of Sparassis latifolia polysaccharides to relieve cyclophosphamide-induced immune injury in liver of mice.

The present study aimed to investigate the impact of Sparassis latifolia polysaccharides (SLPs) on hepatic immune function in cyclophosphamide (CTX)-induced immunocompromised mice. Our findings demonstrated that SLPs effectively suppressed the production of alanine aminotransferase (ALT), aspartate aminotransferase (AST), inflammatory factors, and acute phase proteins, while improving the hepatic oxidative stress state. Additionally, SLPs exerted inhibitory effects on inflammatory cell infiltration within hepatic tissue.

Robust fluorinated cellulose composite aerogels incorporating radiative cooling and thermal insulation for regionally adaptable building thermal management.

Passive radiative cooling (PRC) is an emerging sustainable technology that plays a key role for achieving the goal of carbon neutrality. However, several challenges remain for PRC materials in their practical application in building thermal management, including overcooling problems and unsatisfactory cooling efficiency caused by solar absorption and parasitic heat gains. In this work, fluorinated cellulose-based composite aerogels (FCCA) integrating thermal insulation and PRC were developed by a facile manufacturing strategy that combined phase separation and freeze-drying.

A glucomannan from defatted Ganoderma lucidum spores: structural characterization and immunomodulatory activity via activating TLR4/MyD88/NF-κB signaling pathway.

Ganoderma lucidum spores are tiny mature germ cells ejected from the abaxial side of the pileus and were responsible for multiple pharmacological properties. The defatted G. lucidum spores are the byproducts after the extraction of G.