Publications by authors named "Ksir Salma"
Liver Fibrosis in Rheumatoid Arthritis Patients Treated with Methotrexate.
Curr Rheumatol Rev
October 2021
Introduction: Methotrexate (MTX) is a highly effective therapy for patients with rheumatoid arthritis (RA). However, it has been associated with a range of liver related adverse events. The aim of our study was to evaluate the prevalence rate of liver fibrosis in RA patients and to assess the correlation of cumulative MTX dose with hepatic fibrosis in our context.
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- Rheumatoid arthritis (RA) can be categorized into seropositive (presence of rheumatoid factor or anti-citrullinated protein antibodies) and seronegative (absence of both), with 20% of cases being seronegative.
- An observational study with 294 patients revealed that 90% were seropositive, showing significant differences in disease severity, deformation, and joint destruction between the two groups.
- The findings suggest that in the observed Moroccan population, seropositive RA is more prevalent and often associated with greater clinical severity and complications.