Cellular immune breadth of an Omicron-specific, self-amplifying monovalent mRNA vaccine booster for COVID-19.

Selecting a booster vaccine strategy that generates cellular immune breadth is crucial for effectively recalling cellular reservoirs upon infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants. This post hoc analysis from a multicentre, randomized phase 3 study (CTRI/2022/10/046475) compared the cellular immune breadth induced by self-replicating mRNA (samRNA) vaccine GEMCOVAC-OM, encoding Omicron B.1.

Range of Motion Assessment using a Digital Voice Assistant.

Range of motion (ROM) is an important indicator of an individual's physical health, and its degradation impacts their ability to perform activities of daily living. The elderly are particularly susceptible to mobility loss due to muscular decline, neuromuscular disorders, sedentary lifestyle, etc. Thus, they must undergo periodic ROM assessments to track their physical well-being and consult doctors for any decline in ROM.