Publications by authors named "Kseniya V Nevskaya"
Article Synopsis
- - A new strategy for preventing cancer metastasis involves using a combination of three specific microRNAs (miR-195-5p, miR-520a, and miR-630) that help stop cancer cells from reverting to a stem cell-like state, which is linked to their ability to spread.
- - Researchers conducted transcriptome microarray analysis to observe how these microRNAs affected gene expression in human breast cancer cell lines, finding that the microRNA mixture reduced the cells' ability to form mammosphere clusters in lab conditions.
- - When the microRNAs were delivered in lipid nanoparticles, they effectively prevented lung metastasis in a mouse model, suggesting this combination could lead to promising new treatments that thwart the growth of secondary tumors.
Article Synopsis
- Testing various derivatives of a specific compound demonstrated significant cytotoxic activity against several cancer cell lines, especially for types like 4T1 and HepG2.
- The research revealed that the effective compounds must include both a difluorobenzoxazine fragment and a purine residue connected by a specific length linker.
- Further studies indicated that the most promising compound inhibits DNA biosynthesis, suggesting potential for developing new antitumor agents based on the identified purine conjugates.
Peptide ligands on the PEGylated nanoparticle surface and human serum composition are key factors for the interaction between immune cells and nanoparticles.
Alexandra G Pershina Alexander M Demin Natalya A Perekucha Olga Y Brikunova Lina V Efimova Kseniya V Nevskaya
Colloids Surf B Biointerfaces
January 2023
Article Synopsis
- The surface architecture of nanoparticles, influenced by ligand modifications and protein interactions in biofluids, is essential for their cellular interactions in living organisms.
- In this study, we examined how immune cells interact with magnetic nanoparticles modified with polyethylene glycol (PEG) and peptide ligands, discovering that pHLIP modification improved their uptake by immune cells compared to cycloRGD.
- Although we didn't find notable differences in protein corona composition between the modified and unmodified nanoparticles, variations in nanoparticle uptake were observed among different individuals, highlighting the need to consider personal differences in serum during nanotherapy testing.
Article Synopsis
- There is a link between helminth (worm) infections and reduced allergic diseases, including bronchial asthma, often due to proteins released by the parasites that lower allergic reactions.
- The study examined how hemozoin (Hz), a byproduct from liver flukes, affects immune responses in both mouse and human dendritic cells (hDCs) from individuals with and without asthma, showing increased production of anti-inflammatory cytokines.
- Results indicated that while there were no differences in cellular maturation markers between hDCs from asthma patients and healthy controls, the exposure to Hz combined with lipopolysaccharide (LPS) significantly elevated levels of certain cytokines (IL-10 and IL-12β) in hDC
Article Synopsis
- Liver fluke infection can severely damage the liver but is often overlooked due to unclear symptoms; nanoparticle-enhanced MRI could help detect related liver lesions effectively.
- Researchers modified iron oxide nanoparticles using 3-aminopropylsilane (APS) and analyzed their properties through various techniques to confirm structural integrity and enhance their magnetic capabilities for imaging.
- The study found that these APS-modified nanoparticles can be used as a contrast agent in MRI, showing promising results for diagnosing liver damage caused by liver flukes with minimal toxicity to cells.