Behind the stoNE wall: A fervent activity for nuclear lipids.

The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids. The knowledge about their respective interactions is as important as the individual understanding of each of them. However, while, for example, the interaction of proteins with the other three groups is extensively studied, that of nucleic acids and lipids is, in comparison, very poorly explored.

Daughter cell-targeted mRNAs can achieve segregation without the universal Endoplasmic Reticulum docker She2p.

The establishment of cell polarity in eukaryotes involves the asymmetric distribution of messenger RNAs (mRNAs). In , establishment of the cell polarity that gives rise to mother and daughter cells concurs with the selective targeting of more than 30 mRNAs toward the bud tip. Different mRNAs are segregated at different cell cycle stages, namely early during S phase, in a process dependent on anchoring to the endoplasmic reticulum (ER), or later in G or mitosis, in an ER-independent manner.