Publications by authors named "Kseniia Morozova"
The objective of the current review is to summarize the current state of optical methods in redox biology. It consists of two parts, the first is dedicated to genetically encoded fluorescent indicators and the second to Raman spectroscopy. In the first part, we provide a detailed classification of the currently available redox biosensors based on their target analytes.
View Article and Find Full Text PDFHow aging affects cells of the human brain active milieu remains largely unknown. Here, we analyze astrocytes and neurons in the neocortical tissue of younger (22-50 years) and older (51-72 years) adults. Aging decreases the amount of reduced mitochondrial cytochromes in astrocytes but not neurons.
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- Diabetes increases the risk of ischemic stroke by worsening cerebral damage due to hyperglycemia, though the exact mechanisms are not fully understood.
- This study presents novel findings on the real-time dynamics of hydrogen peroxide (HO) in neuronal mitochondria during ischemic stroke, using advanced technology on both cultured cells and rat brains.
- Results indicate that high blood sugar doesn't impact HO generation in the ischemic area but does worsen the overall effects of the stroke, revealing how elevated glucose levels can alter mitochondrial function in neurons.
Aim: A high-fat diet (HFD) is generally considered to negatively influence the body, the brain, and cognition. Nonetheless, fat and fatty acids are essential for nourishing and constructing brain tissue. Astrocytes are central for lipolysis and fatty acids metabolism.
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