NEW POSSIBILITIES FOR MODIFYING THE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: THE EFFECT OF TIOTROPIUM BROMIDE ON CERTAIN PATHOGENETIC LINKS OF NEOCOLLAGENOGENESIS AND LOCAL IMMUNE DEFENCE OF THE BRONCHIAL TREE.

Objective: The aim: To evaluate the dynamics of the interferon and collagen-IV systems in bronchoalveolar lavage in the treatment of chronic obstructive pulmonary disease using the tiotropium bromide medication.

Patients And Methods: Materials and methods: The study involved 60 COPD patients with bronchial obstruction of the II degree before and on days 30 and 60 of therapy using conventional treatment regimens and inhalations of tiotropium bromide a the dose of 18 mcg once a day. The collagen-IV levels in bronchoalveolar fluid were determined by means of enzyme-linked immunoassay using "StatFax 303 Plus" analyzer and "Biotrin Collagen IV EIA" reagents.

KEY ASPECTS OF ORGANIZATION OF THE PROCESS AND INDIVIDUAL CHARACTERISTICS OF NUTRITION OF PUPILS AND STUDENTS OF DIFFERENT TYPES OF MODERN EDUCATIONAL INSTITUTIONS.

Objective: The aim: Study the key aspects of organization of the process and individual characteristics of nutrition of pupils and students of different types of modern educational institutions.

Patients And Methods: Materials and methods: To adequately assess the process of organization of the regime and individual characteristics of nutrition of pupils and students of different types of modern educational institutions, we have evaluated the key characteristic features of a rational diet: number of daily meals and their duration, food consumption rate, conditions and priorities as well as distribution of dish volume and caloric content in accordance with food intake frequency.

Results: Results: The results of the study have shown a significantly high rate of abuses in individual diet key components.

NITRIC OXIDE METABOLISM IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA ASSOCIATED WITH CORONARY HEART DISEASE AND THE POSSIBILITY OF ITS MEDICAMENTOUS MANAGEMENT.

Objective: The aim: To assess the metabolic by-products of nitric oxide in peripheral blood before and after the medicamentous management in patients suffering from community-acquired pneumonia associated with coronary heart disease.

Patients And Methods: Materials and methods: We have examined 102 patients with community-acquired pneumonia aged from 50 to 65 years, of which 58 patients were diagnosed with coronary heart disease (CHD). The complex treatment of patients with coronary heart disease was supplemented by the additional use of tivortin aspartate, which was taken orally with food at the dose of 5 ml (1g) 3 times a day for 15 days.