Publications by authors named "Ksenia V Sokolova"
Article Synopsis
- Type 2 diabetes involves high blood sugar and reduced function of insulin-producing β-cells, prompting research into potential treatments.
- This study tested the effects of betulin, a natural compound from birch bark, on diabetic rats, focusing on various health parameters over a 28-day period.
- Results indicated that betulin improved blood sugar levels and reduced liver and kidney damage in diabetic rats while promoting the regeneration of β-cells, suggesting it could be a promising treatment for diabetes.
β-cells dysfunction plays an important role in the pathogenesis of type 2 diabetes (T2D), partially may be compensated by the generation of extra-islet insulin-producing cells (IPCs) in pancreatic acini and ducts. Pdx1 expression and inflammatory level are suggested to be involved in the generation of extra-islet IPCs, but the exact reasons and mechanisms of it are unclear. Macrophages are key inflammatory mediators in T2D.
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