Publications by authors named "Ksenia Magidey-Klein"
J Immunother Cancer
June 2021
Article Synopsis
- Metastasis is primarily responsible for cancer-related deaths, and myeloid skewing of hematopoietic cells significantly contributes to this process, although their origins and differentiation patterns from stem cells remain unclear.
- The study utilized mice models with varying metastatic potential to analyze how hematopoietic stem and progenitor cells (HSPCs) in the bone marrow differentiate and interact with cancer cells, using advanced techniques like single-cell RNA sequencing and proteomic screening.
- Results showed that mice with high metastatic tumors had more HSPCs, particularly monocyte-dendritic progenitors, which were influenced by the IL-6 signaling pathway and linked to increased metastasis. This suggests that targeting IL-6 could be a strategy to manage tumor spread
