Publications by authors named "Ksenia A Gaptulbarova"
Article Synopsis
- - A new strategy for preventing cancer metastasis involves using a combination of three specific microRNAs (miR-195-5p, miR-520a, and miR-630) that help stop cancer cells from reverting to a stem cell-like state, which is linked to their ability to spread.
- - Researchers conducted transcriptome microarray analysis to observe how these microRNAs affected gene expression in human breast cancer cell lines, finding that the microRNA mixture reduced the cells' ability to form mammosphere clusters in lab conditions.
- - When the microRNAs were delivered in lipid nanoparticles, they effectively prevented lung metastasis in a mouse model, suggesting this combination could lead to promising new treatments that thwart the growth of secondary tumors.
Background: the present study aims to prove or disprove the hypothesis that the state of copy number aberration (CNA) activation of WNT signalling pathway genes accounts for the ability of differentiated tumour cells to emerge from postchemotherapy shock.
Methods: In the first step, the CNA genetic landscape of breast cancer cell lines BT-474, BT-549, MDA-MB-231, MDA-MD-468, MCF7, SK-BR-3 and T47D, which were obtained from ATCC, was examined to rank cell cultures according to the degree of ectopic activation of the WNT signalling pathway. Then two lines of T47D with ectopic activation and BT-474 without activation were selected.
Purpose: Mutations of the PI3K/AKT/mTOR signaling pathway occur in 70% of all breast cancers and represent a clinically useful marker for disease prognosis and patient management. The purpose of this work was to study the main somatic PIK3CA gene mutations in breast cancer patients and the search for a relationship with the main clinical and pathological characteristics and the effect of neoadjuvant chemotherapy (NAC).
Methods: The study involved 29 patients with luminal B breast cancer.