Publications by authors named "Krzysztofa Odrzywol"
Article Synopsis
- The ubiquitin proteasome system is emerging as a promising area for drug discovery, particularly targeting ubiquitin specific proteases (USPs) like USP28, which is linked to the c-Myc oncogene.
- Researchers have discovered the first inhibitors of USP28 that selectively bind to it and also affect a closely related enzyme, USP25, while showing minimal impact on other deubiquitinases.
- These inhibitors were found to influence c-Myc levels and induce cancer cell death, though their effectiveness is limited due to a narrow therapeutic window when tested against normal cells.
Nutrient provision after sprint exercise enhances mammalian target of rapamycin (mTOR) signaling. One suggested that nutrient sensor is the class III phosphatidylinositol 3-kinase, vacuolar protein sorting 34 (Vps34), not previously studied in human skeletal muscle. It is hypothesized that oral ingestion of essential amino acids (EAA) and carbohydrates (Carb) increases Vps34 activity and mTOR signaling in human skeletal (hVps34) muscle after sprint exercise.
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