Red blood cell deformability in patients with claudication after pain-free treadmill training.

Objectives: To assess the effect of pain-free treadmill training on red blood cell deformability and walking distance in patients with claudication.

Design: Randomized-controlled trial of exercise training.

Setting: Patients were recruited from the primary care, vascular outpatient clinic.

Rheological properties of erythrocytes in patients suffering from erysipelas. Examination with LORCA device.

The rheological properties of erythrocytes: elongation and the aggregation, as well as basic peripheral blood parameters: RBC number, hematocrit, MCV, MCH, MCHC reticulocytes, fibrinogen level, ESR, and glucose level were studied in a group of erysipelas patients. The concentration of malonyl dialdehyde (MDA) in erythrocytes was also measured, as an indicator of oxidative stress exerted. The study involved 18 erysipelas patients and 18 healthy subjects.

Experimental model of pain-free treadmill training in patients with claudication.

Objective: Treadmill training in claudication is often based on walking exercise to a pain threshold or longer to the maximum muscle pain of the lower limbs. This kind of exercise may cause an inflammatory response. The purpose of this study was to determine whether pain-free treadmill training using walking exercise to 85% of the distance to onset of claudication pain can significantly improve pain-free walking distance in patients with intermittent claudication and to evaluate whether this kind of program may induce an inflammatory response leading to the progression of atherosclerosis.

Effects of phenylhydrazine or recombinant human erythropoietin on deformability and activity of dehydrogenase glucose-6-phosphate and acetylcholinesterase in Wistar rats blood enriched in reticulocytes.

Deformability and activity of the enzymes: acetylcholinesterase (AChE) and dehydrogenase glucose-6-phosphate (G-6-PD), were assayed for RBC enriched in immature reticulocytes. Reticulocytosis was evoked by administration of two different drugs: recombinant human erythropoietin (rHuEPO) and phenylhydrazine (PHZ) to two groups of Wistar rats. After treatment with the former compound, a group of animals exhibited 17.

Deformability and enzymes activities of red blood cells in hemodialysed and peritoneal dialysed patients with chronic renal disease.

These studies were focused on the influence of two treatment methods of patients with chronic renal disease on RBC deformability. In peritoneal dialysed-patients (PD) erythrocytes exhibited a decrease in their deformability as compared to control subjects whereas this parameter in RBC deriving from hemodialysed patients (HD) was not altered. The alleviating effect of plasma components on deformability of erythrocytes was confirmed after the isolation of a pure faction of these cells as the parameter became worse.

Rheological and biochemical examination of red blood cells after treatment with different pharmacological and toxic substances.

Rheological and enzymatic properties of red blood cells (RBC) were investigated in vitro after the treatment with vasoactive drug - buflomedil (bfl) and toxic substance - 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Studies with bfl included two different concentrations of the drug: 90 microg/ml of blood and 10 microg/ml of blood. The former concentration of the drug corresponds to the amount of bfl which is taken daily by a patient, the latter one is the highest peak of this drug in plasma.

Iron metabolism in boys involved in intensive physical training.

The purpose of the present study was to compare some haematological and iron-related parameters of prepubertal boys (10-12 years old) involved in intensive physical training program in preparation for the national championship with nontrained age-matched subjects. For this purpose, iron stores, haemoglobin, ferritin and serum transferrin receptor concentrations were taken into account. The athletes' dietary intakes were similar to the respective intakes in the control group.