Receptor GP IIb/IIIa as an Indicator of Risk in Vascular Events.

Type 2 diabetes causes a significant risk of cardiovascular diseases, leading to 70% of deaths in patients with diabetes. The effective treatment of diabetes significantly reduces the risk of requiring the involvement of specialists from various fields of medicine. This research aimed to assess the risk of cardiovascular events based on selected biochemical parameters (glycoprotein [GP] IIb/IIIa, von Willebrand factor [vWf], fibrinogen) and their changes in response to physical exercise.

Physical activity - related changes in ADMA and vWF levels in patients with type 2 diabetes: A preliminary study.

Background: The activity and the role of methylarginine in diabetic patients are subject to continuous research. The mechanism through which diabetes or insulin resistance increases asymmetric dimethylarginine (ADMA) serum levels is not fully understood. Studies indicate increased ADMA serum levels in patients with hypertension, hypercholesterolemia and hyperhomocysteinemia.

A relationship between serological markers of chronic C. pneumoniae and CMV infection and hsp60 in patients with atherosclerotic carotid stenosis.

Unlabelled: A number of epidemiological studies conducted over the last decade indicate a relationship between specific pathogen infections and the development of atherosclerosis, although no pathogenetic pathways connecting these two have been determined. Recent reports support the role of heat shock proteins (HSPs) in atherogenesis. The HSPs are also believed to be a link between the infection and the development of atherosclerotic lesions.

[Serum level of sL-selectin and leukocyte surface expression of L-selectin in patients with type 2 diabetes].

Unlabelled: The aims of the study were assessment of serum level of sL-selectin and leukocyte (neutrophil and monocyte) surface expression of L-selectin in peripheral blood. Subjects and methods. Eighty patients with type 2 diabetes were enrolled in the study.

[Neutrophil surface expression of adhesion molecule CD11b in patients with type 2 diabetes].

Aims: 1. Assessment of cell surface expression of adhesion molecule CD11b on peripheral blood neutrophils in patients with type 2 diabetes without vascular complications. 2.

[Role of polymorphonuclear leukocytes in development vascular complications in diabetes].

Unlabelled: Polymorphonuclear leukocytes (PMN) play role in the development of diabetic vascular complications. Activation PMN is associated with increased expression of adhesion molecules on the surface those cells. The aim of this study was to evaluate the expression of the beta2-integrin (CD11b/CD18) and selectin-L (CD 62l) on the surface of the peripheral blood polymorphonuclear leukocytes in type 2 diabetes with vascular complications.

[A case of cutaneous vasculitis in a patient with systemic lupus erythematosus].

We present case of 55 years old female with systemic lupus erythematosus (SLE) and necrotic ulcerations in lower limbs. Etiology of this lesions was complex. In the presented case, vasculitis (microvasculitis) accompanying systemic inflammatory connective tissue disease coincides with deficiency of protein S and venous insufficiency lower limbs.

[The role of anti-dsDNA autoantibodies in the pathogenesis of atherosclerosis].

This paper presents involvement of autoimmune mechanism, and especially the role of autoantibodies anti-dsDNA (double stranded DNA) in atherosclerosis. Authors on the basis of results from experimental models and human studies demonstrate contribution of antibodies anti-DNA in the pathogenesis of atherosclerosis. Antibodies anti-dsDNA may play a role in atherosclerosis by promoting accumulation of cholesterol in macrophages and smooth muscle cells, influence on dyslipoproteinemias, cytotoxicity and releasing cytocines.