Understanding Immune-Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform.

The aging of the immune system drives systemic aging and the pathogenesis of age-related diseases. However, a significant knowledge gap remains in understanding immune-driven aging, especially in brain aging, due to the limited current in vitro models of neuroimmune interaction. Here, the authors report the development of a human brain organoid microphysiological analysis platform (MAP) to discover the dynamic process of immune-driven brain aging.

Human Spinal Organoid-on-a-Chip to Model Nociceptive Circuitry for Pain Therapeutics Discovery.

The discovery of new pain therapeutics targeting human nociceptive circuitry is an emerging, exciting, and rewarding field. However, current models for evaluating prospective new therapeutics [e.g.

Metabolomic analysis of exosomal-markers in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is a worldwide malignancy with high mortality rates and poor prognosis due to the lack of effective biomarkers for early detection. Exosomes have been extensively explored as attractive biomarkers for cancer diagnosis and treatment. However, little is known about exosome metabolomics and their roles in ESCC.

[Radioactivity levels of the air inhaled by personnel of a radioiodine therapy unit].

The mean activity concentration of 131I during inhalation by the nuclear medicine personnel was measured at therapeutic activity applications of 22 GBq (600 mCi) per week. The activity concentration reached its maximum in the exhaled air of the patients 2.5 to 4 hours after oral application.

Airborne radioiodine contamination caused by 131I treatment.

Estimation of exposure from 131I inhaled from unsealed sources during laboratory procedures and from that exhaled by patients treated with 131I has revealed that the permissible levels have been exceeded by a factor of 2-5, although the absorbed activity was found to be between 1 and 10% of the maximum permissible absorption of 131I inhaled through the lungs. The fall in 131I concentration in the air exhaled by 19 hyperthyroid patients, to whom 131I was administered in a dose of several hundred MBq, could be expressed by a two-component equation, which reflects the changes in 131I concentration in the blood.