Neuro-Behcet Disease and Ocular Inflammation: A Case Report and Literature Review.

To describe a case of panuveitis with occlusive vasculitis leading to the diagnosis of neuro-Behcet disease (NBD) and discuss the relationship between uveitis and NBD. Case report with a literature review of ocular inflammation in NBD. A 26-year-old woman with a seven-month history of recurrent cerebral venous sinus thromboses (CVST) and right-sided hemiparalysis secondary to rhombencephalitis presented with bilateral panuveitis and occlusive retinal vasculitis.

Theranostics: Leveraging Molecular Imaging and Therapy to Impact Patient Management and Secure the Future of Nuclear Medicine.

Nuclear medicine is experiencing a renaissance, with U.S. Food and Drug Administration approval recently being obtained for theranostic agents and a wide variety of such agents soon to impact patient care significantly in the era of precision medicine.

F-NaF-PET/CT for the detection of bone metastasis in prostate cancer: a meta-analysis of diagnostic accuracy studies.

Purpose: This meta-analysis aims to establish the diagnostic performance of F-NaF-PET/CT for the detection of bone metastases in prostate cancer patients. The performance of F-NaF-PET/CT was compared with other imaging techniques in the same cohort of patients.

Methods: A systematic search was performed in PubMed/Medline and EMBASE (last Updated, September 28, 2018).

Use of quantitative SPECT/CT reconstruction in Tc-sestamibi imaging of patients with renal masses.

Objective: Technetium-99m (Tc)-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) has previously been shown to allow for the accurate differentiation of benign renal oncocytomas and hybrid oncocytic/chromophobe tumors (HOCTs) apart from other malignant renal tumor histologies, with oncocytomas/HOCTs showing high uptake and renal cell carcinoma (RCC) showing low uptake based on uptake ratios from non-quantitative single-photon emission computed tomography (SPECT) reconstructions. However, in this study, several tumors fell close to the uptake ratio cutoff, likely due to limitations in conventional SPECT/CT reconstruction methods. We hypothesized that application of quantitative SPECT/CT (QSPECT) reconstruction methods developed by our group would provide more robust separation of hot and cold lesions, serving as an imaging framework on which quantitative biomarkers can be validated for evaluation of renal masses with Tc-sestamibi.

Patterns of uptake of prostate-specific membrane antigen (PSMA)-targeted F-DCFPyL in peripheral ganglia.

Objective: Radiotracers targeting prostate-specific membrane antigen (PSMA) have increasingly been recognized as showing uptake in a number of normal structures, anatomic variants, and non-prostate-cancer pathologies. We aimed to explore the frequency and degree of uptake in peripheral ganglia in patients undergoing PET with the PSMA-targeted agent F-DCFPyL.

Methods: A total of 98 patients who underwent F-DCFPyL PET/CT imaging were retrospectively analyzed.

Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis.

Objective: To compare the rate of abnormal brain metabolism by FDG-PET/CT to other paraclinical findings and to describe brain metabolism patterns in autoimmune encephalitis (AE).

Methods: A retrospective review of clinical data and initial dedicated brain FDG-PET/CT studies for neurology inpatients with AE, per consensus criteria, treated at a single tertiary center over 123 months. Z-score maps of FDG-PET/CT were made using 3-dimensional stereotactic surface projections with comparison to age group-matched controls.

Diagnostic Value of F-FDG PET/CT Versus MRI in the Setting of Antibody-Specific Autoimmune Encephalitis.

Diagnosis of autoimmune encephalitis presents some challenges in the clinical setting because of varied clinical presentations and delay in obtaining antibody panel results. We examined the role of neuroimaging in the setting of autoimmune encephalitides, comparing the utility of F-FDG PET/CT versus conventional brain imaging with MRI. A retrospective study was performed assessing the positivity rate of MRI versus F-FDG PET/CT during the initial workup of 23 patients proven to have antibody-positive autoimmune encephalitis.