Publications by authors named "Krystian Mroz"
Pre-symptomatic scintigraphic and genetic cascade screening in cardiac transthyretin amyloidosis.
Eur J Nucl Med Mol Imaging
November 2024
Purpose: While early diagnosis is crucial, as new treatments can significantly slow the progression of the disease, there is growing evidence on the application of novel imaging techniques for detecting transthyretin amyloidosis (ATTR) in pre-symptomatic stages. This study aimed to evaluate the utility of pre-symptomatic scintigraphic imaging cascade screening for early detection of ATTR.
Methods: During the period from 2020 to 2024, we conducted a prospective study that enrolled 100 consecutive adults.
Amyloid cardiomyopathy (CA) was previously considered a rare disease; however, rapid advancements in imaging modalities have led to an increased frequency of its diagnosis. The aim of this prospective study was to assess the prevalence and clinical phenotype of transthyretin amyloidosis (ATTR) cardiomyopathy in patients exhibiting unexplained increased left ventricular (LV) wall thickness. From 2020 to 2022, we enrolled 100 consecutive adults with unexplained increased LV wall thickness in the study.
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- The study investigates the relationship between protein carbonylation levels in the plasma and clinical outcomes in patients with coronary artery disease (CAD) during long-term follow-up.
- Elevated levels of carbonylated proteins were found in the majority of patients, with those experiencing severe cardiovascular events showing significantly higher levels compared to others.
- The findings suggest that increased protein carbonylation might contribute to a higher risk of cardiovascular incidents, indicating its potential as a predictor of adverse outcomes in atherosclerotic vascular disease.
Balloon aortic valvuloplasty for severe aortic stenosis may reduce mitral regurgitation in mid-term follow-up.
Postepy Kardiol Interwencyjnej
September 2022
Introduction: Mitral regurgitation (MR) is a frequent complication in patients with severe aortic stenosis (AS).
Material And Methods: Echocardiographic assessment of MR was performed at baseline, at 30 days and at 6 months after balloon aortic valvuloplasty (BAV).
Results: Data of 271 patients were included in our final analysis, of which 21.