Publications by authors named "Krysten Leigh Jones"
Repeat RNA expansion disorders of the nervous system: post-transcriptional mechanisms and therapeutic strategies.
Crit Rev Biochem Mol Biol
February 2021
Article Synopsis
- Many neurological disorders, like myotonic dystrophy and Huntington's disease, are caused by the expansion of short repeat sequences in genes, affecting both coding and non-coding regions of RNA.
- Recent research has uncovered mechanisms, such as bidirectional transcription and RNA foci formation, that contribute to the diseases caused by these repeat expansions.
- The review discusses potential therapeutic strategies to target harmful RNA processes, aiming to reduce toxic RNA, prevent RNA foci, and mitigate the harmful effects of peptide repeats in various repeat expansion disorders.