Evaluation of the Timing of Opioid Administration: A Pilot Study.

Objective: Approximately 20% of the errors committed at hospitals are attributed to medication error, which is one of the main things threatening the safety of patients. Every hospital has a list of medications that are considered time-critical scheduled medications. Opioids with a specific schedule of administration are included on these lists.

Synthesis, Anti-Cancer and Anti-Migratory Evaluation of 3,6-Dibromocarbazole and 5-Bromoindole Derivatives.

In this study, a new series of -alkyl-3,6-dibromocarbazole and -alkyl-5-bromoindole derivatives have been synthesized and evaluated in vitro as anti-cancer and anti-migration agents. Cytotoxic and anti-migratory effects of these compounds were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines and an insight on the structure-activity relationship was developed. Preliminary investigations of their anti-cancer activity demonstrated that several compounds have moderate antiproliferative effects on cancer cell lines with GI values in the range of 4.