NEUTROPHIL TRAPS AS AN IMMUNE RESPONSE MECANISM IN PETIENTS WITH EROSIVE DISEASES OF THE UPPER GASTROINTESTINAL TRACT.

To optimize the methods for determining neutrophil extracellular traps in peripheral blood and studying their level in the norm and in patients with candidiasis with inflammatory and erosive diseases of the upper gastrointestinal tract on the basis of the Institute of Gastroenterology of the National Academy of Medical Sciences and Clinical Association of Emergency Medicine, Dnipro, Ukraine, in 2019-2021. 42 patients with candidiasis with inflammatory and erosive diseases of the upper gastrointestinal tract were examined, including 10 women and 32 men aged 35-56 years, who made up the main group (MG). These patients were divided into two groups according to the results of microbiological examination of the mucous membranes of the gastrointestinal tract: group 1 consisted of 20 patients with oropharyngeal candidiasis of the oral cavity; Group 2 consisted of 22 patients with candidiasis in the esophagus and stomach with or without oropharyngeal candidiasis.

PREOPERATIVE PREPARATION OF DONOR ZONES OF PERFORANT FLAPS BY THE METHOD OF TRAINING PERFORANT VESSELS WITH NEGATIVE PRESSURE.

One of the key factors in achieving favorable treatment outcomes when planning reconstructive surgeries using perforant flaps is the choice of recipient vessels. Their identification causes certain difficulties both at the planning stage and during the operation. The aim of the study was to develop the most rational modes of action of negative pressure on the skin of the thigh.

RESEARCH OF THE TEACHING EFFICIENCY THE SECTION "THERMAL TRAUMA" USING INTERACTIVE TECHNOLOGIES.

The goal of research is the formation of educational community of students who have been certain skills and ready to acquire new knowledge in the process of communicating with each other, joint cognitive activity through the use of interactive technologies - the method of cooperative groups. This method is used to search for common features in different schemes of medical care for patients with burns. The study involved 8 student groups of the 3rd year of the Faculty of Medicine, State Medical University, Dnipro.

INDICATORS OF THE CELL-MEDIATED IMMUNITY IN SURGICAL PATIENTS WITH GASTRODUODENAL ULCERS COMPLICATED BY BLEEDING.

Objective: The aim: To determine the peculiarities of indicators dynamic of cellular level of immunity in patients with gastroduodenal ulcer complicated by bleeding and microbial contamination the periulcerous area.

Patients And Methods: Materials and methods: 80 patients with gastroduodenal ulcers complicated by bleeding were studied. Among patients in the main group, 18 (22.

CLINICAL FEATURES OF GASTROINTESTINAL ULCERATIVE BLEEDING IN ELDERLY PATIENTS COMPLICATED BY CARDIO-VASCULAR PATHOLOGY.

Objective: The aim: To determine clinical and endoscopical features of gastroduodenal hemorrhages in elderly patients with concomitant cardio-vascular pathology in a way by studying, main indicators of the immune system for drawing up further tactics.

Patients And Methods: Material and methods: The study included 609 patients with ulcerative gastroduodenal bleeding, complicated by cardio-vascular system pathology in 2017-2019 years. The observed patients were distributed into the groups: I - patients, who received treatment according to the standard system of cardiovascular pathology treatment (n=541), II - "double" therapy (n=68).

[LAPAROSCOPIC HERNIOPLASTY IN INCARCERATED INGUINAL HERNIAS].

The results of laparoscopic hernioplasty, using TAPP method and operation of Lichtenstein in 80 patients, suffering incarcerated inguinal hernia, were analyzed. While achievement of similar good and excellent immediate and late results, laparoscopic procedure has several advantages and may be used as a method of choice for treatment of inguinal hernia.

[Dynamics of a CD3-lymphocytes contents during intraabdominal sorption-transmembranous dialysis in patients with extended peritonitis].

The analysis of clinical and laboratory material in patients, suffering extended peritonitis,was conducted. There was established, that application of the sorption-transmembranous dialysis and abdominal cavity sanation guarantees the CD3 lymphocytes protection and the endotoxicosis severity reduction.

[Dynamics of catecholamines in serum of patients with gastroduodenal ulcers complicated by hemorrhage].

The dynamics of the catecholamines content in the blood serum of the patients, suffering gastroduodenal ulcer, complicated by hemorrhage, was analyzed. The biggest raising of the investigated index level was observed in patients while presence of gastric cancer, complicated by hemorrhage. These changes correlate with the blood loss severity enhancement, the state of unstable endoscopic hemostasis, high activity of the inducible NO-synthase of the peri-ulceral zone mucosa.

[The sorption therapy in complex treatment of abdominal sepsis].

The results of diagnosis and treatment of 31 patients, suffering abdominal sepsis of various origin, are analyzed. There was elaborated algorithm of postoperative treatment ot the patients. Depending on peculiarities of postoperative tactic of treatment, all the patients were divided into two groups.

[Treatment strategy for ulcerative gastrointestinal bleeding from the upper gastrointestinal tract].

The deep statistical analysis of patients treatment with the ulcerous gastroduodenal bleeding set 2 years works of Center of the gastroduodenal bleeding of Dnepropetrovsk is conducted. It is exposed, that wide application of methods of endoscopic haemostasis and endoscopic monitoring allowed substantially to reduce the amount of operations at this category of patients and improve the results.

[Changes of the gastroduodenal mucosa in ulcer complicated by hemorrhage].

Deep clinico-morphological analysis was performed in patients, suffering gastroduodenal ulcer, complicated by hemorrhage. The most severe inflammatory changes were revealed in gastric antrum mucosa. These changes correlated with features of unstable hemostasis and massive blood loss.

[Comparative characteristic of various methods of hernioplasty for inguinal hernias].

The experience of performance of elective and urgent herniotomy intervention in 1548 patients for inguinal hernia was analyzed. There were compared the results of laparoscopic hernioplasty according to TAPP method and Lichtenstein operation. It was established, that achieving similarly good and excellent results, laparoscopic method owes several advantages and can be used as a method of choice in the treatment of inguinal hernia.

[Clinical, morphological, and microbiological characteristics of the Mallory-Weiss syndrome].

The profound clinico-morphological and immunological analysis was performed in patients suffering Mallory-Weiss syndrome (MWS). Doing endoscopic and morphological investigations the most dangerous foci of the affection were revealed and there links with the disease course severity and the recurrences rate established. The signs of unstable haemostasis were revealed according to the endoscopic investigation data.

[Efficacy of antibiotic prophylaxis using zinacef in postoperative period].

The results of intravenous injection of Zinacef for purulent--septic complications in patients with various acute surgical diseases of the abdominal cavity organs were presented. Main principles and rules of antibioticoprophylaxis and antibioticotherapy conduction in surgery were substantiated.

[Long-term results of the surgical treatment of stomach ulcer].

The results of surgical treatment of 384 patients with gastric ulcer disease within the follow-up period of 1 to 10 and more years have been analysed. Two hundred and fifty patients underwent gastric resection, 85--organ-preserving operation with vagotomy, 49--closure of a perforative ulcer. On the basis of data of clinico-functional investigations, the advantages and disadvantages of the methods of surgical treatment used have been studied.

[Aspects of surgical treatment of peptic ulcer complicated by hemorrhage].

The article presents materials of clinical examination of 407 patients with ulcer disease of the stomach and duodenum complicated by bleeding. The nearest and long-term results of vagotomy and resection of the stomach are shown in comparison. Totally, organ-preserving interventions give more promising results than resection of the stomach especially by the Billroth-II method.

[The effect of 5-fluorouracil on lipid metabolism in patients with acute pancreatitis].

The state of lipid metabolism was investigated in 72 patients with acute pancreatitis using the method of thin-layer chromatography on "Silufol" plates. It was established that the level of general phospholipids underwent a reduction in destructive pancreatitis. The level of triglycerids reduced sharply after treatment with 5-fluoruracil.