Ultrasound-mediated oxygen delivery to lower extremity wounds.

Critical limb ischemia (CLI), an end result of peripheral ar- terial disease, remains a major clinical challenge. Wound healing in patients with CLI can be difficult due to diminished tissue oxygen- ation, often leading to recalcitrant ulcers and frequent limb loss. Nu- merous therapies, including hyperbaric oxygen therapy (HBOT), have been used to correct this regional ischemia, although often with mixed results.