Simultaneous treatment of intracranial complications of paranasal sinusitis.

Purpose: The objective of this study was to analyse 51 patients with intracranial complications of sinusitis treated in the Department of Otolaryngology and Laryngeal Oncology at Poznań University of Medical Sciences from 1964 to 2016.

Materials And Methods: Males made up a significant portion of study participants at 70.5%.

Intracranial complications from sinusitis.

Introduction: Despite increasingly better diagnostic and therapeutic methods intracranial sinogenic complications, invariably pose a direct threat to the lives of patients and a challenge for otolaryngologists.

Aim: The aim of the study was to analyze patients with intracranial sinogenic complications treated at the Department of Otolaryngology and Otolaryngological Oncology of Poznań University of Medical Sciences in the years 2000-2013.

Material And Methods: Analysis covered the period from January 2000 to December 2013.

[Anterior commissure status in patients with larynx cancer].

Aim Of The Work: Assessment of directions and ways of cancer spreading in the anterior commissure of the larynx, depending on the tumor location, age, sex of patients in a clinical trial and in microscopic serial section study.

Materials And Methods: The study included 50 larynx preparations obtained from open partial and total laryngectomies (F-7; M-43). For the assessment of larynx anterior commissure microscopic status 28 larynx preparations with macroscopic free anterior commissure were used.

[The role of surgical treatment for nasopharyngeal carcinoma].

Aim: Presentation of experiences and results of surgical treatment of nasopharyngeal carcinoma.

Material And Methods: 4 patients with nasopharyngeal carcinoma operated in Department of Otolaryngology and Laryngological Oncology of Poznan University of Medical Sciences between 2006 and 2011. In one case operation was performed via transpalatal approach and in other three cases via transfacial approach (via lateral rhinotomy).

PRAME expression in head and neck cancer correlates with markers of poor prognosis and might help in selecting candidates for retinoid chemoprevention in pre-malignant lesions.

Objectives: PRAME (Preferentially Expressed Antigen in Melanoma) is a tumor-associated antigen recognized by immunocytes, and it induces cytotoxic T cell-mediated responses in melanoma. PRAME expression in tumors interferes with retinoic acid receptor (RAR) signaling thus promoting tumor progression. Here, we study PRAME expression in head and neck squamous cell carcinoma (HNSCC) to determine its potential clinical significance.

Head and neck squamous carcinomas with exophytic and endophytic type of growth have the same prognosis after surgery and adjuvant radiotherapy.

Head and neck squamous cell carcinomas (HNSCC) are characterized by exophytic or endophytic growth. We hypothesized that the growth pattern predicts outcome and associates with distinct clinical and immunological profiles. Tumors obtained from 60 HNSCC patients treated with surgery and adjuvant radiotherapy were identified as exophytic or endophytic.

Evolution in management of otogenic brain abscess.

Objective: To present the therapeutic results related with treating 103 patients with cerebral abscesses of otogenic origin during 3 various time frames (1953-1977, 1978-1989, and 1990-2011).

Patients: A total of 103 patients with cerebral abscess of otogenic origin.

Interventions: Diagnostics and treatment.

[Results of treatment of 101 otogenic brain abscesses--56-years experience].

Introduction: Inflammatory process in the areas of the middle ear creates a possible danger related with the development of extratemporal and intratemporal complications. The most dangerous of those include meningitis and cerebral abscesses, which are still present.

Aim: The aim of the work is to present 101 patients with cerebral, in temporal lobe, and cerebellar abscesses of aural origin throughout the period of 56 years, namely between 1953 and 2009.

Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack.

Toll-like receptors (TLR) expressed on inflammatory cells play a key role in host defense against pathogens, benefiting the host. TLR are also expressed on tumor cells. To evaluate the role of TLR in tumor cells, we investigated TLR4 signaling effects on human head and neck squamous cell carcinoma (HNSCC).

[Experiences with treatment of extended laryngo-tracheal stenosis with employment of transversal resection of trachea].

Unlabelled: The aim of this study is to evaluate the results obtained in Department of Otolaryngology et Oncology with transversal resection of trachea acc. to Pearson technique for postintubation stenosis.

Methods: from January 2000 to January 2008 ten patients with subglottic postintubation stenosis underwent surgical treatment, using Pearsons method of operation with preservation of recurrent nerves and no postopereative tracheostomy.

[Paratracheal lymph nodes in patients with larynx and hypopharynx cancer in radiological and clinical examination].

Introduction: Paratracheal lymph nodes receive the lymph from the larynx, hypopharynx, esophagus, thyroid gland and trachea. It is evaluated, that metastases to these nodes occur in about 10-30% of patients with cancer of the larynx, hypopharynx or cervical esophagus. These metastases can lead to the most tragic complication after total laryngectomy, which is the stomal recurrence, Paratracheal lymph nodes are not accessible to examine by palpation or ultrasonography.

[Antiplatelet therapy can unmask an inherited bleeding disorder. Aspirin-like defect of platelets does not protect against atherosclerosis].

Some inherited platelet disorders may be revealed late, as in the presented case of a 68-year-old-man. Recurrent epistaxis following peri-interventional antiplatelet therapy (after three elective percutaneous coronary interventions) and an episode of upper gastrointestinal haemorrhage required aspirin withdrawal and less frequent clopidogrel use. Platelet studies showed an aspirin-like defect resulting in a lack of arachidonate-induced platelet aggregation.

[Scared atrophy of the cervical part of trachea as an effect of prolongated intubation].

Tracheal intubation is presently one of the basic medical procedures. It is connected with many different complications. One of them is tracheal stenosis, which occurs in 6-21 percent of patients after intubation of the trachea.

[Local changes in the oral cavity in patients after operation of malignant tumours of the tongue and bottom of the oral cavity].

Unlabelled: This study is aimed an objective and subjective evaluation of local changes after operations of malignant tumours of the tongue and the bottom of the oral cavity.

The Material And Methods: we have examined 74 patients (70 men and 4 women) treated in Department of Otolaryngology of the University School of Medical Sciences in Poznań with recognized of malignant tumour of the tongue and floor of the mouth. On the base of subjective and objective ultrasound and x-ray examination with use of contrast and stereognostic test it was evaluated movability, alteration of articulation zones, regularity of swallowing acts, sense of taste and efficiency of stereognosion.

[Stomal recurrence after total laryngectomy].

Unlabelled: Stomal recurrence after total laryngectomy is a very serious complication, in general with dismal prognosis. There are only a few possibilities of treatment, so stress should be put on prevention.

Material: In the ENT Department Poznań University of Medical Sciences between 1997-2004 829 total laryngectomy were performed, because of advanced laryngeal cancer (T3, T4).

[Prognostic value of low hemoglobin concentration in adjuvant radiotherapy after total laryngectomy in group of patients with laryngeal cancer].

Purpose: To investigate the impact of hemoglobin concentration (Hb) at the start and end of radiotherapy, and the drop of hemoglobin concentration during radiotherapy on the loco-regional control in postoperative radiotherapy for patients with advanced laryngeal cancer.

Materials And Methods: Between January 1993 and December 1996, 254 patients with pT3 or pT4 and pN0-pN2 laryngeal cancer were treated with a total laryngectomy and adjuvant radiotherapy (RT). The median age of patients was 56.

[The impact of paraglottic space for laryngeal cancer spread].

Introduction: Malignant laryngeal cancer is the most common tumor of the head and neck. Radical laryngectomy not only causes the changes in breathing routes and disability to retain the air in the chest during the physical effort, but it also deprives the patient of a possibility to communicate. In order to limit and avoid mutilating surgery i.

[Advances in the diagnosis of unknown primary carcinoma of the neck].

Unlabelled: The diagnosis of carcinoma of unknown primary is set, when histologically the neck metastases are confirmed but the primary focus is not possible to be found or occurs during the follow-up. The CUP-nodes constitute 2-20% of all neck metastases in laryngological entities. The squamous cell carcinoma or anaplastic carcinoma recognized in the neck nodes suggest, that the primary focus is localised in the head and neck region.

[Tumor escaping mechanisms present in microenvironment of laryngeal cancer].

In tumor tissue obtained from a group of 21 patients treated surgically for laryngeal carcinoma, the expression of Fas, Fas-L, CD3, TCR zeta chain and Bcl-2 were estimated. It has been shown that tumor often express: Fas-L, Fas, Bcl-2, the molecules which may influence increased tumor survival. On the other hand lack of MHC class I antigen expression on tumor cells frequently has been observed.

[Cytotoxic T lymphocytes in peripheral blood and regional lymph nodes in laryngeal cancer patients].

Cytotoxic T cells is an unique lymphocyte subpopulation able to recognize in specific manner and kill tumor cells. Therefore they constitute an important cells engaged in anti-tumor defense. The aim of the study was to determinate cytotoxic T cells frequency in peripheral blood and among lymphocytes isolated from regional lymph nodes.

[Transversal resection of trachea as the method of treatment of postintubational stenosis].

We present an experience with transversal tracheal resection with end-to-end anastomosis in 3 patients with extensive subglottic stenosis because of prolonged intubation. All the patients were treated chirurgically based on the Pearson's method. In order to attein the fixation of tracheal stumbs, poroplastic splint was applied into the lumen of the trachea and patency of airways was protected by tracheotomy.

[Structure of the laryngeal anterior commissure and its role in spread of malignant neoplasms].

Since many years anterior commissure of larynx is a field of scientific research. However it is still known as a "X space", or "plane 0", because of lack of its universally accepted anatomical and clinical definition. Authors have made literature survey about development and structure of the anterior commissure of larynx.

[Time factors in postoperative radiotherapy in the years 1986-19990 and 2000-2002].

Postoperative radiotherapy plays an important role in management of advanced laryngeal cancer. Numerous retrospective data has given strong evidence that prolongation of treatment time of radiotherapy has negative influence on treatment results. Generally, it might be concluded that each additional day of irradiation is connected with drop of locoregional control in range from 1% to 2%.

[Adjuvant radiotherapy of the neck lymph modes in patients after partial laryngectomies].

Adjuvant radiotherapy after partial laryngectomy is still controversial mainly due to high level morbidities which may occur in the irradiated larynx. The aim of this study was to evaluate the results (locoregional control) and toxicities (acute and late) of combined treatment. Between 1996 and 2001 the group of 14 patients (12 men, 2 women), aged less than 60 years, Karnofsky scale > 70, were investigated retrospectively.

[Gastro-oesophageal reflux disease presenting as laryngeal pathology--epidemiology, symptoms, diagnosis. Preliminary report].

Unlabelled: Symptoms from the ears, throat, nose and larynx--the laryngeal mask's manifestations of gastroesophageal reflux disease (GERD) are important clinical problem of significant occurrence.

Aim: (1) Determination of GERD's frequency of occurrence, especially within the group of patients with the pathology of the posterior laryngeal commissure. (2) Evaluation of the effective algorithms for detecting and management of patients demonstrating symptoms of laryngeal mask, which develop on the ground of gastroesophageal reflux disease.