Assessment of the concomitant action of XBD173 and interferon β in a mouse model of multiple sclerosis using infrared marker bands.

Disease modifying therapies including interferon-β (IFNβ) effectively counteract the inflammatory component in relapsing-remitting multiple sclerosis (RRMS) but this action, generally associated with severe side effects, does not prevent axonal/neuronal damages. Hence, axonal neuroprotection, which is pivotal for MS effective treatment, remains a difficult clinical challenge. Growing evidence suggested as promising candidate for neuroprotection, Emapunil (AC-5216) or XBD173, a ligand of the mitochondrial translocator protein highly expressed in glial cells and neurons.

Machinable glass-ceramics forming as a restorative dental material.

MgO, SiO(2), Al(2)O(3), MgF(2), CaF(2), CaCO(3), SrCO(3), and P(2)O(5) were used to prepare glass-ceramics for restorative dental materials. Thermal properties, phases, microstructures and hardness were characterized by DTA, XRD, SEM and Vickers microhardness. Three-point bending strength and fracture toughness were applied by UTM according to ISO 6872: 1997(E).