Clinical Impact of Rare and Compound Mutations of Epidermal Growth Factor Receptor in Patients With Non-Small-Cell Lung Cancer.

Background: Standard therapy of advanced non-small-cell lung cancer harboring an activating mutation in the epidermal growth factor receptor (EGFR) gene is treatment with tyrosine kinase inhibitors (TKI). However, for rare and compound mutations of the EGFR gene, the clinical evidence of TKI therapy is still unclear.

Patients And Methods: A total of 2906 lung cancer samples were analyzed for EGFR mutations during routine analysis between 2010 and 2017.

Alpha-smooth muscle actin distribution in the pulmonary vasculature comparing hypoplastic and normal fetal lungs.

We investigated the intra-acinar pulmonary vascular muscularization in the developing human fetal lung between the 17th and 24th gestational weeks, that is, during the canalicular phase of lung development. Fifteen hypoplastic and 25 normal developed lungs were included in this study using monoclonal alpha-smooth muscle (sm) actin antibodies for smooth muscle detection. Computer-aided image analysis was performed for morphometrical measurements and statistical evaluation.

[Failure of dental implants following psychosomatic disturbances in the stomatognathic system--a clinical-catamnestic study].

Nowadays dental implantations are highly successful if individual indications are taken into consideration. From our experiences with patients from the Research Institute for Psychopathology and Psychosomatics, we would like to point out a contraindication for the treatment of dental implants, which until now has been hardly considered. A special case report shows that psychosomatic problems and pains in the maxillofacial region can be the cause of failure of dental implants.

[Midfacial and mandibular body fractures in children and adolescents].

1423 patients with maxillo-facial trauma were admitted for hospital treatment from 1980-1986. Midfacial and/or mandibular corpus fractures were present in 87 juvenile cases. The follow-up study of 64 patients of this group revealed some interesting points: 1.

Osteomyelitis due to Cryptococcus neoformans in advanced age. Case report and review of literature.

In an 84-year-old man cryptococcosis with a pronounced osteomyelitic course (involvement of a rib, two thoracic vertebrae, the sacrum and a femur) was diagnosed histologically post mortem, thus directing attention to cryptococcosis in advanced age. The presumptive chronic course of the Cryptococcus neoformans (Cr. n.

[Interdisciplinary investigations on the criticism of the term 'anesthesia dolorosa'].

3291 patients with facial pain and/or complaints in the orofacial region were examined from 1972-1988 by both the maxillofacial surgeon and the neurologist at the departments of maxillofacial surgery and psychosomatic medicine of the Zentrum für Zahn-, Mund- und Kieferkrankheiten of the University of Münster. Only 27 cases of genuine trigeminal neuralgia could be found in those 17 years. At the same time, however, 31 patients presented with anaesthesia dolorosa after various operations on the fifth cranial nerve.