Publications by authors named "Krolenko E"
Article Synopsis
- The study examined lipid and carbohydrate metabolism as well as adipokines and growth factors in three mouse models with different metabolic disorders: alimentary obesity, leptin-resistant obesity, and diabetes mellitus.
- In the alimentary obesity model, mice showed moderate liver fat, enlarged adipose tissue, and elevated levels of glucose, adiponectin, and cholesterol.
- In the leptin-resistant model, severe tissue issues were noted, along with high blood sugar and leptin but low triglycerides and certain growth factors.
- The diabetes mellitus model revealed a decrease in insulin-producing cells and lower levels of important hormones like adiponectin and leptin, along with high insulin levels.
We studied the production of short-chain fatty acids (SCFA) by the intestinal microbiota in mice with obesity caused by a diet and a genetic defect in the leptin receptor gene. In mice, intestinal contents were examined and SCFA were quantitatively assayed by gas chromatography. SCFA concentration in the intestinal contents of mice with alimentary obesity model was significantly lower in the first phase of the experiment (day 14), and the change in their production in dynamics was fundamentally different from this process in the control group (standard diet).
View Article and Find Full Text PDF