Preconditions for Including the Effects of Urease and Nitrification Inhibitors in Emission Inventories.

Urease and nitrification inhibitors can reduce ammonia and greenhouse gas emissions from fertilizers and manure but their effectiveness depends on the conditions under which they are used. Consequently, it is essential for the credibility of emission reductions reported in regulatory emission inventories that their effectiveness is assessed under real-world conditions and not just in the laboratory. Here, we specify the criteria we consider necessary before the effects of inhibitors are included in regulatory emission inventories.

Accountable care organizations and HPV vaccine uptake: a multilevel analysis.

Objectives: To examine associations between accountable care organization (ACO) membership and human papillomavirus (HPV) vaccination and to evaluate variation in HPV vaccination across ACO providers.

Study Design: Retrospective cohort study.

Methods: We analyzed the records of commercially insured children and adolescents aged 11 to 14 years using Connecticut's All-Payer Claims Database from January 2012 to December 2017.

Mitigation of ammonia and methane emissions with manure amendments during storage of cattle slurry.

This study aimed at assessing the efficacy of manure amendments in abating ammonia (NH) and methane (CH) emissions during storage. Two experiments were carried out. Experiment 1 was conducted using 20 L of slurry for 98 days.

An integral assessment of the impact of diet and manure management on whole-farm greenhouse gas and nitrogen emissions in dairy cattle production systems using process-based models.

Feed management decisions are crucial in mitigating greenhouse gas (GHG) and nitrogen (N) emissions from ruminant farming systems. However, assessing the downstream impact of diet on emissions in dairy production systems is complex, due to the multifunctional relationships between a variety of distinct but interconnected sources such as animals, housing, manure storage, and soil. Therefore, there is a need for an integral assessment of the direct and indirect GHG and N emissions that considers the underlying processes of carbon (C), N and their drivers within the system.

[Multiple sclerosis and bipolar disorder: an overlap between soma and psyche].

This clinical vignette describes a 29-year-old woman who had her first neurological manifestations of multiple sclerosis (MS) on the same day as a second lifetime manic episode as part of a bipolar I disorder. The patient was stable for eight years before this episode. An MRI-scan conducted during admission showed multiple demyelinating lesions in the frontal cortex, which might have influenced the development and course of the manic episode.

The Development of the Oncology Center of Excellence Patient-Friendly Language Glossary of Oncology Clinical Trial Terms.

Oncology clinical trials terms and definitions have become increasingly complex, which has led to shortcomings among research staff and healthcare providers in informing clinical trial participants with the study results and consenting procedures in simple language. Understanding oncology clinical trial terms is of critical importance to assist patients and caregivers in making cancer treatment decisions, including enrollment into clinical trials. The U.

Maintaining and Improving the Oral Health of Young Children.

Oral health is an integral part of the overall health of children. Dental caries is a common and chronic disease process with significant short- and long-term consequences. The prevalence of dental caries remains greater than 40% among children 2 to 19 years of age.

Revisiting sampling duration to estimate NO emission factors for manure application and cattle excreta deposition for the UK and Ireland.

According to the available guidelines, good practices for calculating nitrous oxide (NO) emission factors (EFs) for livestock excreta and manure application include that sampling duration should be of at least one year after the nitrogen (N) application or deposition. However, the available experimental data suggest that in many cases most emissions are concentrated in the first months following N application. Therefore resources could be better deployed by measuring more intensively during a shorter period.

Low NO emissions associated with sheep excreta deposition in temperate managed lowland grassland and extensively grazed hill pasture.

Nitrous oxide (NO) is a potent greenhouse gas (GHG) whose emission from soil can be enhanced by ruminant excretal returns in grasslands. The default (Tier 1) emission factors (EF; i.e.

Incorporating Oral Health into Pediatric Practice: National Trends 2008, 2012, 2018.

Objective: Oral health is a critical component of children's overall health, but past research has found that pediatricians report barriers to implementing oral health into practice. Recently, policies have further delineated the importance of oral health in primary medical care. We sought to determine how pediatricians' practices and perceived barriers related to oral health involvement have changed since 2008.

Parent-reported penicillin allergies in children: A qualitative study.

Background: Penicillin allergies are commonly reported in children. Most reported penicillin allergies are false, resulting in the unnecessary selection of alternative antibiotic treatments that promote antibiotic resistance. While formal allergy testing is encouraged to establish a diagnosis of penicillin allergy, children are rarely referred for allergy testing, and study of parents' experiences and perceptions of their child's reported penicillin allergy is limited.

SARS-CoV-2 infection activating a novel variant of the gene and subsequently causing development of CADASIL.

Introduction: In the following study we describe the diagnostic process and further case analysis of a 30-year-old woman admitted with typical COVID-19 symptoms, who subsequently developed additional symptoms suggesting cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy (CADASIL).

Material And Methods: Other than the standard diagnostic procedures, whole genome sequencing (WGS) was used, which led to following findings. A new variant of the gene, which led to CADASIL-like symptoms, was found, and it had been most likely activated by the SARS-CoV-2 infection.

Effect of contrasting phosphorus levels on nitrous oxide and carbon dioxide emissions from temperate grassland soils.

Agricultural practices such as repeated fertilization impact carbon (C), nitrogen (N) and phosphorus (P) cycling and their relationships in the plant-soil continuum, which could have important implications for the magnitude of greenhouse gas emissions. However, little is known about the effect of C and N additions under contrasting soil P availability status on nitrous oxide (NO) and carbon dioxide (CO) emissions. In this study, we conducted a field-based experiment that investigated the impact of long-term (23 years) P management (no (P0, 0 kg P ha), low (P15, 15 kg P ha) and high (P45, 45 kg P ha) P inputs) on NO and CO emissions following two C + N application events in two managed grassland ecosystems with loam and sandy loam soils.

Full Inversion Tillage (FIT) during pasture renewal as a potential management strategy for enhanced carbon sequestration and storage in Irish grassland soils.

It has been suggested that the sequestration of CO by agricultural soils offers a means to reduce atmospheric greenhouse gas (GHG) concentrations and in turn mitigate the impacts of climate change. Carbon sequestration by grassland soils, which account for more than 60% of agricultural land use in Ireland, could contribute to a successful net reduction of atmospheric GHG emissions in accordance with the COP21 Paris Agreement. However, current estimates of soil carbon sequestration are variable and it is likely that many permanent grasslands are close to saturation.

U.S. FDA Drug Approvals for Breast Cancer: A Decade in Review.

Over the last decade, the treatment of patients with breast cancer has been greatly impacted by the approval of multiple drugs and indications. This summary describes 30 FDA approvals of treatments for breast cancer from 2010 to 2020. The trial design endpoints, results, and regulatory considerations are described for each approved indication.

U.S. FDA Drug Approvals for Gynecological Malignancies: A Decade in Review.

Over the last decade, there has been tremendous progress in the treatment of patients with gynecologic cancers with a changing therapy landscape. This summary provides an overview of U.S.

Overall survival in patients with hormone receptor-positive, HER2-negative, advanced or metastatic breast cancer treated with a cyclin-dependent kinase 4/6 inhibitor plus fulvestrant: a US Food and Drug Administration pooled analysis.

Background: Cyclin-dependent kinase 4/6 inhibitors (CDKIs) are oral targeted agents approved for use in combination with endocrine therapy as first-line or second-line treatment of patients with hormone receptor-positive, HER2-negative, advanced or metastatic breast cancer. We previously reported the pooled analyses of progression-free survival in patients in specific clinicopathological subgroups, all of whom received consistent benefit from the addition of a CDKI to hormonal therapy. Here, we report the pooled overall survival results in patients treated with a CDKI and fulvestrant.

Uncertainties in direct NO emissions from grazing ruminant excreta (EF) in national greenhouse gas inventories.

Excreta deposition onto pasture, range and paddocks (PRP) by grazing ruminant constitute a source of nitrous oxide (NO), a potent greenhouse gas (GHG). These emissions must be reported in national GHG inventories, and their estimation is based on the application of an emission factor, EF (proportion of nitrogen (N) deposited to the soil through ruminant excreta, which is emitted as NO) Depending on local data available, countries use various EFs and approaches to estimate NO emissions from grazing ruminant excreta. Based on ten case study countries, this review aims to highlight the uncertainties around the methods used to account for these emissions in their national GHG inventories, and to discuss the efforts undertaken for considering factors of variation in the calculation of emissions.

Ammonia and nitrous oxide emission factors for excreta deposited by livestock and land-applied manure.

Manure application to land and deposition of urine and dung by grazing animals are major sources of ammonia (NH ) and nitrous oxide (N O) emissions. Using data on NH and N O emissions following land-applied manures and excreta deposited during grazing, emission factors (EFs) disaggregated by climate zone were developed, and the effects of mitigation strategies were evaluated. The NH data represent emissions from cattle and swine manures in temperate wet climates, and the N O data include cattle, sheep, and swine manure emissions in temperate wet/dry and tropical wet/dry climates.

Beneficial effects of multi-species mixtures on NO emissions from intensively managed grassland swards.

In a field experiment, annual nitrous oxide (NO) emissions and grassland yield were measured across different plant communities, comprising systematically varying combinations of monocultures and mixtures of three functional groups (FG): grasses (Lolium perenne, Phleum pratense), legumes (Trifolium pratense, Trifolium repens) and herbs (Cichorium intybus, Plantago lanceolata). Plots received 150 kg ha year nitrogen (N) (150 N), except L. perenne monocultures which received two N levels: 150 N and 300 N.

Source partitioning using NO isotopomers and soil WFPS to establish dominant NO production pathways from different pasture sward compositions.

Nitrous oxide (NO) is a potent greenhouse gas (GHG) emitted from agricultural soils and is influenced by nitrogen (N) fertiliser management and weather and soil conditions. Source partitioning NO emissions related to management practices and soil conditions could suggest effective mitigation strategies. Multispecies swards can maintain herbage yields at reduced N fertiliser rates compared to grass monocultures and may reduce N losses to the wider environment.

DATAMAN: A global database of nitrous oxide and ammonia emission factors for excreta deposited by livestock and land-applied manure.

Nitrous oxide (N O), ammonia (NH ), and methane (CH ) emissions from the manure management chain of livestock production systems are important contributors to greenhouse gases (GHGs) and NH emitted by human activities. Several studies have evaluated manure-related emissions and associated key variables at regional, national, or continental scales. However, there have been few studies focusing on the drivers of these emissions using a global dataset.