Fully Automated MRI-based Analysis of the Locus Coeruleus in Aging and Alzheimer's Disease Dementia using ELSI-Net.

Introduction: The Locus Coeruleus (LC) is linked to the development and pathophysiology of neurodegenerative diseases such as Alzheimer's Disease (AD). Magnetic Resonance Imaging based LC features have shown potential to assess LC integrity in vivo.

Methods: We present a Deep Learning based LC segmentation and feature extraction method: ELSI-Net and apply it to healthy aging and AD dementia datasets.

Noradrenergic neuromodulation in ageing and disease.

The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates cognition and autonomic functions and is involved in the brain's immune response. The extent of degeneration to the LC in healthy ageing remains unclear, however, noradrenergic dysfunction may contribute to the pathogenesis of Alzheimer's (AD) and Parkinson's disease (PD).

Reorientational dynamics in highly asymmetric binary low-molecular mixtures-A quantitative comparison of dielectric and NMR spectroscopy results.

Previously, we scrutinized the dielectric spectra of a binary glass former made by a low-molecular high-T component 2-(m-tertbutylphenyl)-2'-tertbutyl-9,9'-spirobi[9H]fluorene (m-TPTS; T = 350 K) and low-T tripropyl phosphate (TPP; T = 134 K) [Körber et al., Phys. Chem.

Reorientational dynamics of highly asymmetric binary non-polymeric mixtures - a dielectric spectroscopy study.

We present an analysis of dielectric spectra measured for a specially designed non-polymeric asymmetric binary glass former characterized by a large difference of the component's T (ΔT = 216 K). We cover the whole additive concentration range from 4% up to 90% (by mass). Two main relaxations α and α are identified, which are characterized by well separated time scales and are attributed to the dynamics associated with the high-T component (α) and the low-T component (α).

Main and secondary relaxations of non-polymeric high-T glass formers as revealed by dielectric spectroscopy.

A series of high-Tg glass formers with Tg values varying between 347 and 390 K and molar masses in the range of 341 and 504 g mol-1 are investigated by dielectric spectroscopy. They are compared to paradigmatic reference systems. Differently polar side groups are attached to a rigid non-polar core unit at different positions.

Organic Glasses of High Glass Transition Temperatures Due To Substitution with Nitrile Groups.

The glass transition temperature () of a molecular glass depends on its molar mass. However, the nature of intermolecular interactions also plays a major role in both the glass transition temperature and its glass-forming ability. In this context, we report on novel molecular glasses containing nitrile groups and investigate the influence of this highly polar group on and the glass-forming ability.

Physicians' and consumers' conflicting attitudes toward health care advertising.

The purpose of this paper is to explore the conflicting attitudes held by physicians and health care consumers toward health care advertising in an attempt to resolve the question. The paper introduces the differing positions held by the two groups. The rationale behind physicians' attitudes is then presented that advertising can be unethical, misleading, deceptive, and lead to unnecessary price increases.

The dilemma of conflicting attitudes: survey results or community perceptions?

This present article investigates conflicting community attitudes and formal survey results. The survey results suggest that patients viewed their physicians' and nurses' competency and care very highly, as well as receiving satisfactory care in specialized departments. The results further suggest that hospital meals were less satisfactory in terms of patient enjoyment of meals and with the services of the dietitian.

Communication climate.

Group practice managers can become more effective communicators through conscious awareness of the verbal and nonverbal messages thay they send and receive.