Meta-analysis to determine the effects of supplementation of niacin during the transition or lactating period on performance in dairy cows.

Niacin, a key component of pyridine nucleotides, plays a vital role in over 200 metabolic reactions, including carbohydrate, lipid, and AA metabolism. This meta-analysis aimed to evaluate the effects of niacin supplementation on lactational performance in dairy cows. We hypothesized that niacin supplementation during the transition or lactating periods would enhance the productive performance of dairy cows.

Associations of body condition score, body condition score change, and hyperketonemia with mastitis, reproduction, and milk production.

Body condition score and hyperketonemia (HYK) have been associated with diseases, fertility, and culling, but data are contradictory about their association with pregnancy loss. Our objective was to conduct a retrospective cohort study to investigate associations between BCS, BCS change (ΔBCS), blood BHB, and HYK with mastitis, pregnancy per artificial insemination (P/AI), pregnancy loss (PGL), milk yield, and risk of leaving the herd on a Michigan dairy farm that uses an automated milking system (AMS). We recorded BCS for cows prepartum (14 d before calving) and postpartum (14-21 DIM), and multiparous cows were evaluated for HYK between 3 and 7 DIM.

On-farm supplementation of rumen-protected niacin: A randomized clinical trial.

B vitamins, including niacin (vitamin B), are synthesized by rumen microbes, but supplementation may provide additional benefits for ruminant health and productivity. Supplementing rumen-protected niacin (RPN) during the transition period can reduce lipolysis after calving and, consequently, may improve health and fertility of dairy cattle later in lactation. Our objective was to determine if supplementing RPN during the first 21 DIM would improve the health of dairy cows on a commercial dairy farm.

Effects of rumen-protected niacin on inflammatory response to repeated intramammary lipopolysaccharide challenges.

Nutritional strategies that improve an animal's resilience to various challenges may improve animal health and welfare. One such nutrient is niacin, which has reduced inflammation in mice, humans, and swine; however, niacin's anti-inflammatory effects have not been investigated in cattle. Our objective was to determine whether rumen-protected niacin (RPN) alters lactating dairy cows' inflammatory response to intramammary LPS challenges, whether RPN resulted in any carryover effects, and whether repeated LPS challenges result in signs of immune tolerance or innate immune training.

Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes.

Background: Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric acid (BHBA; the primary blood ketone) has inhibitory effects on the function of bovine leukocytes. BHBA is a ligand of HCAR2 and the activation of these receptors promotes an anti-inflammatory response which may be related with immunosuppression observed in transition dairy cattle.

Educating the nurses of tomorrow: exploring first-year nursing students' reflections on a one-week senior peer-mentor supervised inspiration practice in nursing homes.

Background: Worldwide, the healthcare system stresses a severe deficit of nurses because of elevated levels of work-induced stress, burnout and turnover rates, as well as the ageing of the nursing workforce. The diminishing number of nursing students opting for a career in nursing older people has exacerbated this shortage. A determining factor in the choice of a career within the field of residential care for nursing students is educational institutions offering students learning opportunities with positive learning experiences.

The effects of feeding α-amylase-enhanced corn silage with different dietary starch concentrations to lactating dairy cows on milk production, nutrient digestibility, and blood metabolites.

Corn silage is one of the most common ingredients fed to dairy cattle. Advancement of corn silage genetics has improved nutrient digestibility and dairy cow lactation performance in the past. A corn silage hybrid with enhanced endogenous α-amylase activity (Enogen, Syngenta Seeds LLC) may improve milk production efficiency and nutrient digestibility when fed to lactating dairy cows.

Does feeding starch contribute to the risk of systemic inflammation in dairy cattle?

In the high-producing dairy cow, providing an adequate supply of digestible energy is essential. One strategy to meet this need is to provide fermentable starch from cereal grains or silages like corn, barley, or wheat. Unfortunately, excess dietary starch increases the risk of rumen acidosis.

Evaluation of reticuloruminal temperature for the prediction of clinical mastitis in dairy cows challenged with Streptococcus uberis.

Automated monitoring devices have become increasingly utilized in the dairy industry, especially for monitoring or predicting disease status. While multiple automated monitoring devices have been developed for the prediction of clinical mastitis (CM), limitations in performance or applicability remain. The aims of this study were to (1) detect variations in reticuloruminal temperature (RRT) relative to an experimental intramammary challenge with Streptococcus uberis and (2) evaluate alerts generated automatically based on variation in RRT to predict initial signs of CM in the challenged cows based on severity of clinical signs and the concentration of bacteria (cfu/mL) in the infected quarter separately.

Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells.

NAA10 is a major -terminal acetyltransferase (NAT) that catalyzes the cotranslational -terminal (Nt-) acetylation of 40% of the human proteome. Several reports of lysine acetyltransferase (KAT) activity by NAA10 exist, but others have not been able to find any NAA10-derived KAT activity, the latter of which is supported by structural studies. The KAT activity of NAA10 towards hypoxia-inducible factor 1α (HIF-1α) was recently found to depend on the hydroxylation at Trp38 of NAA10 by factor inhibiting HIF-1α (FIH).

The effects of pelleted dried distillers grains and solubles fed with different forage concentrations on rumen fermentation, feeding behavior, and milk production of lactating dairy cows.

The physical form of feeds can influence dairy cow chewing behavior, rumen characteristics, and ruminal passage rate. Changing particle size of feeds is usually done through grinding or chopping forages, but pelleting feed ingredients also changes particle size. Our objective was to determine if pelleted dried distillers grains and solubles (DDGS) affected the feeding value for lactating dairy cattle.

Nutritional status of patients with advanced cancer: the value of using the subjective global assessment of nutritional status as a screening tool.

In patients suffering from advanced neoplastic disease, malnutrition is a common complication affecting both the survival and quality of life. In order to monitor early dietary interventions, an assessment of patients' nutritional status is essential. We assessed the nutritional status of 46 patients using two different methods: 1) an objective method of nutritional assessment and 2) the subjective global assessment (SGA) technique.