Butterfly Diagram and Other Properties of Plage Areas from Kodaikanal Ca ii K Photographs Covering 1904 - 2007.

Ca ii K observations of the Sun have a great potential for probing the Sun's magnetism and activity, as well as for reconstructing solar irradiance. The Kodaikanal Solar Observatory (KoSO) in India, houses one of the most prominent Ca ii K archives, spanning from 1904 to 2007, obtained under the same experimental conditions over a century, a feat very few other sites have achieved. However, the KoSO Ca ii K archive suffers from several inconsistencies (e.

Sun-like stars produce superflares roughly once per century.

Stellar superflares are energetic outbursts of electromagnetic radiation that are similar to solar flares but release more energy, up to 10 erg on main-sequence stars. It is unknown whether the Sun can generate superflares and, if so, how often they might occur. We used photometry from the Kepler space observatory to investigate superflares on other stars with Sun-like fundamental parameters.

The Quantitative In Vivo Assessment of Diabetic and Non-Diabetic Skin Wound Healing Using Phasor-FLIM Approach.

A quantitative assessment of wound status in a murine model was developed using phasor plot presentation of fluorescence lifetime imaging microscopy (FLIM) data. The quantitative assessment is based on calculating Bhattacharyya distance between g coordinates of FLIM data phasor plot density distributions of wound and healthy skin. The approach was validated for both diabetic and non-diabetic mice wounds, including during low-dose photodynamic therapy (LDPDT).

The effect of exposure to RF-EMF from the laboratory simulator of 5G NR base station on physiological parameters and cognitive abilities of male wistar rats of different ages.

In this article, the impact of radiofrequency electromagnetic field (RF-EMF) exposure from a simulated base station for the 5G New Radio (5G NR) telecommunication on rats was studied. The base station affects all age groups of the population, thus, for the first time, the experiment was conducted on male Wistar rats of three different ages (juvenile, adult, and presenile). The base station exposure parameters were chosen according to ICNIRP recommendations for limiting the exposure to radiofrequency electromagnetic field: frequency 2.

[Relationship between the pain severity, use of non-steroidal anti-inflammatory drugs and blood pressure in elective large joint arthroplasty of the lower extremities].

Aim: To evaluate the changes in blood pressure (BP), the severity of pain syndrome and non-steroidal anti-inflammatory drugs (NSAIDs) use patterns in patients hospitalized for elective arthroplasty of large joints of the lower extremities during the postoperative period.

Materials And Methods: This study included 374 patients. In all patients, medical history, antihypertensive therapy and history of NSAIDs usage were collected, BP was measured, and the severity of pain was assessed via a 10-point scale before surgery, as well as 1 and 3 months after arthroplasty.

An Evaluation of Lymphedema Using Optical Coherence Tomography: A Rat Limb Model Approach.

Lymphedema is a pathology caused by poor lymphatic flow which may lead to complete disability. Currently, precise, non-invasive techniques for quantifying lymphedema are lacking. In this paper, the results of an in vivo assessment of lymphedema via a developed small-animal model using the hindlimbs of rats and an optical coherence tomography (OCT) technique are presented.

Quantitative Assessment of Low-Dose Photodynamic Therapy Effects on Diabetic Wound Healing Using Raman Spectroscopy.

One of challenges that faces diabetes is the wound healing process. The delayed diabetic wound healing is caused by a complicated molecular mechanism involving numerous physiological variables. Low-dose photodynamic therapy (LDPDT) provides excellent results in rejuvenation and wound healing.

Estimation of the Regenerative Potential of para-Tyrosol in the Model of Testicular Insufficiency Caused by Damage to Spermatogonial Stem Cells.

The regenerative properties of p-tyrosol were investigated in a model of testicular insufficiency caused by a toxic effect on spermatogonial stem cells (single administration of paclitaxel in the maximum tolerable dose). Against the background of p-tyrosol administration, we observed an increase in the number of normal spermatogonia and Sertoli cells, stimulation of spermatogenesis, and renewal of the spermatogenic tissue. The treatment with p-tyrosol also led to a decrease in DNA damage in cells of the testicular tissue.

The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography.

The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound's state during wound healing including the effect of low-dose photodynamic therapy using topical application of two different photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser doses of 1 J/cm and 4 J/cm. It was concluded that the laser dose of 4 J/cm was better compared to 1 J/cm and allowed the wound healing process to accelerate.

In Vivo Quantification of the Effectiveness of Topical Low-Dose Photodynamic Therapy in Wound Healing Using Two-Photon Microscopy.

The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis (SAAID) was analyzed by two-photon microscopy. SAAID measured at 60-80 μm depths was shown to be a suitable quantitative parameter to monitor wound healing.

Global temperature modes shed light on the Holocene temperature conundrum.

Reconstructions of the global mean annual temperature evolution during the Holocene yield conflicting results. One temperature reconstruction shows global cooling during the late Holocene. The other reconstruction reveals global warming.

The Sun is less active than other solar-like stars.

The magnetic activity of the Sun and other stars causes their brightness to vary. We investigated how typical the Sun's variability is compared with other solar-like stars, i.e.

Analysis of Collagen Spatial Structure Using Multiphoton Microscopy and Machine Learning Methods.

Pathogenesis of many diseases is associated with changes in the collagen spatial structure. Traditionally, the 3D structure of collagen in biological tissues is analyzed using histochemistry, immunohistochemistry, magnetic resonance imaging, and X-radiography. At present, multiphoton microscopy (MPM) is commonly used to study the structure of biological tissues.

Experimental Study of the Effectiveness of Phenolic Antioxidants in Male Infertility Caused by Pathospermia.

The effect of phenolic antioxidants (dihydroquercetin, p-tyrosol, dibornol) on the morphology, functions, and redox processes in the reproductive cells of male rats was studied on the model of experimental pathospermia. All antioxidants reduced the percentage of degenerative forms of spermatozoa. Dibornol was most effective.

Publisher's Note: Solar Irradiance Variability is Caused by the Magnetic Activity on the Solar Surface [Phys. Rev. Lett. 119, 091102 (2017)].

This corrects the article DOI: 10.1103/PhysRevLett.119.

Solar Irradiance Variability is Caused by the Magnetic Activity on the Solar Surface.

The variation in the radiative output of the Sun, described in terms of solar irradiance, is important to climatology. A common assumption is that solar irradiance variability is driven by its surface magnetism. Verifying this assumption has, however, been hampered by the fact that models of solar irradiance variability based on solar surface magnetism have to be calibrated to observed variability.

Effect of a water-maze procedure on the redox mechanisms in brain parts of aged rats.

The Morris water maze (MWM) is a tool for assessment of age-related modulations spatial learning and memory in laboratory rats. In our work was investigated the age-related decline of MWM performance in 11-month-old rats and the effect exerted by training in the MWM on the redox mechanisms in rat brain parts. Young adult (3-month-old) and aged (11-month-old) male rats were trained in the MWM.

Dihydroquercetin effects on the morphology and antioxidant/prooxidant balance of the prostate in rats with sulpiride-induced benign hyperplasia.

A course of dihydroquercetin (antioxidant) injections to 5-month-old Wistar rats with sulpiride-induced benign prostatic hyperplasia led to reduction of proliferative activity in the glandular structures and to attenuation of the inflammatory reaction in the tissue. Prostatic antioxidant/prooxidant balance returned to normal after the treatment.

[Prooxidant and antioxidant activity of blood plasma and histology of internal organs of rats after intravenous administration of magnetite nanoparticles].

The effect of a single and multiple intravenous injections of a nanosized magnetite suspension on total prooxidant and antioxidant activity of blood plasma has been investigated by the method of luminol-dependent chemoluminescence. Magnetite nanoparticles possess dose-dependent prooxidant properties due to their iron atoms and at the same time their trigger compensatory activation of antioxidant systems in the rat blood plasma. After a single intravenous administration of magnetite the studied parameters of blood plasma returned to the normal level by the end of the experiment as due to removal ofnanoparticles from the body.

[Influence of simulated hypomagnetic environment in a far space flight on the rhythmic structure of rat's behavior].

Behavior of a group of rats was observed visually and tape recorded continuously from day 19 till the end of 25-d hypomagnetic experiments. Results were statistically processed with the help of Statistica 6.0, time series spectral analysis, and cosinor analysis.

[Antioxidant activity of blood plasma of south Altai's indigenous population of low and medium height altitude areas].

Due to the fact that age change theories are still under discussion a study has been conducted on the estimation of antioxidant and antiradical activity of blood plasma. For the experiment was taken a homogeneous group of people which separate populations differ in geographical and climatic parameters of their living conditions. As a result there has been discovered a dependence of Altaians' antioxidant system upon geographical and climatic conditions, and age.

Air detoxification with nanosize TiO2 aerosol tested on mice.

A method for fast air purification using high concentration aerosol of TiO(2) nanoparticles is evaluated in a model chemical catastrophe involving toxic vapors of diisopropyl fluorophosphate (DFP). Mice are used as human model in a closed 100 dm(3) chamber. Exposure of mice to 37 ppm of DFP vapor for 15 min resulted in acute poisoning.

[Study of interactions between the glycoprotein composition and the antioxidant activity of parietal mucus of the gastrointestinal tract].

Main characteristica of polymerised and degraded glycoproteins of the gastrointestinal tract mucus were revealed. The correlation connections were found between antioxidant activity of the polymerised glycoproteins and their contents ofpolypeptides and M-acetylneuramine acid. In the soluble phase of the mucus (the degraded glycoproteins and other components of the mucus layer), the level of antioxidant activity correlated with the contents of hexosamines.

[The evaluation of the gastroprotective effect of sucralfate in Helicobacter pylori-associated gastric ulcer].

The purpose of the investigation was to study the effects of sucralfate on the biochemical composition as well as the anti-radicals and antioxidative activity (ARA; AOA) of the gastric supra-epithelial mucosal layer (GSEML) in patients with Helicobacter pylori (HP)-associated gastric ulcer (GU). A hundred patients suffering from HP-associated GU were examined. The biochemical composition as well as the ARA and AOA of the GSEML were studied before and after eradication therapy as well as after additional administration of sucralfate.