[Signs of hypercoagulation and activation of fibrinolysis in patients with Wegeners's granulomatosis and Schoenlein-Genoch's purpura].

The patients with Wegener's granulomatosis and Schoenlein-Genoch's purpura included in this study were examined in the E.A.M.

[Experience with rituximab treatment (monoclonal antibodies to B-lymphocyte CD20 receptors) of Wegener's granulomatosis patients with renal impairment].

Aim: To assess efficacy of rituximab in patients suffering from Wegener's granulematosis (WG) with renal disease.

Material And Methods: We analysed clinical laboratory data from 9 WG patients with renal disease treated with rituximab in E.M.

[Pulmonary lesions in Wegener's granulomatosis].

Pulmonary lesions are the commonest and prognostically unfavourable visceral pathology in Wegener's granulomatosis. The author discusses clinically and reongenologically detectable lesions associated with this systemic vasculitis with special reference to its most severe forms (alveolar bleeding and infectious complications frequently caused by active immunosuppressive therapy). Diagnostic (including early) and modem therapeutic modalities of Wegener's granulomatosis are considered.

[Severe Wegener's granulomatosis successfully treated with rituximab].

The paper discusses the problems of the diagnosis and treatment of Wegener's granulomatosis, the most common anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. It describes a clinical case in which the administration of rituximab could achieve remission of severe Wegener's granulomatosis in a young man having numerous adverse reactions associated with the long-term use of high- and average-dose glucocorticoids and nonselective immunosuppressive agents. A place of rituximab in current drug therapy for Wegener's granulomatosis is shown.

[Takayasu syndrome in Horton's disease].

Problems of diagnosis (including early diagnoses) and treatment of giant cell arteritis the commonest form of vasculitis in subjects above 50 years. An aged woman presenting with rheumatic polymyalgia is described in whom cell arteritis was diagnosed by positron emission tomography. Etiology of this disease and it medicamentous treatment are discussed with reference to the patients' age and concomitant pathologies.

[Myocarditis and fibroplastic endocarditis in Wegener's granulomatosis].

The paper describes an autopsy case of Wegener's granulomatosis with a rare variant of a cardiac lesion--the concurrence of aortic valvular disease (aortic regurgitation), fibroplastic endocarditis, and complete transverse blockade, followed by pacemaker implantation. The direct cause of death in the female patient was multiple organ dysfunction: progressive chronic heart failure, adult respiratory distress syndrome, acute hepatorenal failure, and pancreonecrosis. The data available in the Russian and foreign literature on investigations dealing with cardiac pathology in patients with Wegener's granulomatosis are analyzed.

[Churg-Strauss syndrome in patients with cardiac problems].

Clinical observations of patients with Churg-Strauss syndrome and cardiac disorders are reported. In one case, both myocardium and endocardium were affected. Severe cardiac insufficiency was the immediate cause of death in one patient.

[Clinical significance of echocardiography in patients with systemic vasculitis].

The paper reports results of echocardiographic studies of patients with systemic vasculitis treated at E.M. Tareev Clinic during 1991-2006.

[Cardiac lesion in the Churg-Strauss syndrome].

The Churg-Strauss syndrome is a systemic vasculitis, the manifestations of which are asthma, eosinophilia, pulmonary infiltrates, poly- and mononeuropathy, polyserositis. Along with nodular polyarteritis and nonspecific aortoarteritis, the Churg-Strauss syndrome belongs to a group of systemic vasculitis, in the clinical picture of which cardiac lesion is recognized as one of the leading visceral manifestations and may be a common cause of fatal outcomes. In the Churg-Strauss syndrome, cardiac pathology may be associated with the involvement of the endocardium, myocardium, and pericardium.

[Aortal regurgitation and atrioventricular block III in Wegener's granulomatosis].

The article presents a clinical observation of a female patient suffering from Wegener's granulomatosis with a rare variant of cardiac involvement--a combination of an aortal valvular disease (aortal regurgitation) and total atrioventricular blockade--who later underwent pacemaker implantation. The direct cause of the lethal outcome in this patient was destructive pancreatitis. Data from Russian and foreign literature on cardiac pathology in patients with Wegener's granulomatosis are analyzed.

[Cardiac lesion in systemic vasculites: manifestations, diagnosis, and treatment].

The article contains analysis of Russian and foreign literature on cardiac lesions in patients with system vasculites (SV). The frequency of cardiovascular involvement in various SV forms was evaluated. These forms include non-specific aortoarteritis, giant-cell arteritis, nodular polyarteritis, Kawasaki disease, Wegener's granulomatosis, eosinophilic vasculitiis, and granulomatosis.

[The peculiarities of renal lesion in nodular polyarteritis].

Analysis of the medical records of 122 patients with nodular polyarteritis showed that the most frequent visceral manifestations were renal (93.4%), cardial (72%), and gastrointestinal (57.4%) ones.

[Vascular purpura in patients with chronic diffuse hepatic diseases].

The purpose of the study was to evaluate clinical significance of vascular purpura (VP) in diagnostics and establishing prognosis of chronic diffuse hepatic diseases (CDHD). The subjects were 660 patients with CDHD of viral and non-viral origin, who were under long hospital observation. 72 CDHD patients had cutaneous vasculitis.

[Vascular purpura associated with chronic diffusive hepatic pathologies].

The study results related with the rate of vascular purpura in 660 patients with different-type chronic diffusive hepatic pathologies both of the viral and other natures are described in the paper. The main regularities characterizing the phenomenon (spread and possible cause of purpura development) are defined. According to an analysis of actual materials, dermal vasculitis is not an exclusive feature of virus-associated hepatitis or liver cirrhosis.

[The parietal mucin microbial population in different sections of the human gastrointestinal tract].

Microbiological examinations of the human-colon parietal mucin were made in different sections of the human gastrointestinal tract (GIT). Biopsy samples of the human colon mucus tunic were used as the research material. Convincing data were found by research on the importance of the anatomic-and-morphological factor in shaping-up of microbiocenosis of the colon-wall parietal mucin.

[Clinical and prognostic value of lesions in the gastrointestinal tract in systemic vascular purpura].

Aim: To evaluate clinical peculiarities and prognostic value of abdominal syndrome in adult patients with systemic vascular purpura (SVP).

Material And Methods: Incidence, clinical picture, complications of abdominal syndrome, its relations with principal extraintestinal manifestations of SVP were studied in 125 SVP patients. Absorption and barrier functions of the small intestine, their correlations with clinical activity of the disease were investigated in 32 SVP patients with no clinical signs of intestinal affection.

[Abdominal emergencies in systemic vasculitis].

Abdominal lesions are characterized in a patient with acute vascular purpura and a patient with polyarteritis. The former patient developed obturation ileus of the small intestine, the latter--necrosis and multiple intestinal and gall bladder perforation with subsequent peritonitis. In both cases the abdominal syndrome was manifestation of the basic disease.

[Systemic vascular purpura: clinical etiological variants].

Systemic vascular purpura (SVP) represents angiites, heterogeneous by etiology and pathogenesis. Their pathogenetic classification does not fully reflect the clinical picture, course, and prognosis. The authors suggest a clinical etiological approach to differential diagnosis of SVP.

[Cryoglobulinemic vasculitis].

A postmortem case of cryoglobulinemic vasculitis is reported. A 67-year-old male had hemorrhagic component, affection of the kidneys, skin, lungs and gastrointestinal organs. The disease began in 1994 with extreme weakness, headache, fever, skin eruption.

[The experimental use of surfagon, a synthetic analog of luliberin, in follicular ovarian cysts].

The use of a synthetic peptide analog of LH-RH agonist--[D-Ala6, des Gly10, Pro9]-LH-RH ethylamide (surfagon) at microdoses and in short courses returned to normal the ovulatory cycle in the anovulatory condition in rats and caused luteinization of follicular cysts in rats and cows with further normalization of ovarian function. It is assumed that surfagon will be effective for the treatment of anovulatory condition and ovarian follicular cysts in women.

[The effect of nizoral on hypophyseal gonadotropic function and the production of sex steroid hormones by the testes and ovaries in human subjects and experimental animals].

Experiments with mature male and female rats and female mice have shown that nizoral, a nonsteroid estrogenic drug, in a dose of 10 mg/kg stimulates estradiol production in male and female rats, suppresses basal and stimulates LH production, promotes a relative predominance of FSH in female animals, and suppresses FSH in male rats. In humans of a reproductive age, orally taking 200 mg of nizoral during 1-26 weeks, the drug stimulates FSH and LH production, suppressing estradiol production in men. The blood levels of prolactin, testosterone and progesterone are unchanged (the hypophyseal gonadotropic and the peripheral steroid hormones have been radioimmunoassayed).