[Evaluation of intestinal viability on a simulation model of a small ileus based on determination of dielectric parameters].

Interrelationship between dielectric parameters and level of ATPH before and during ischemia, as well as with indices of survival after elimination of strangulation, was estimated on a simulation model of strangulation ileus in rats. The data obtained permit to suppose, that parameter tg δm may be used as effective noninvasive criterion of diagnosis in real time for estimation of the intestinal wall state in strangulation. Resection of the infringed intestine without elimination of strangulation is necessary in tg δm less than 2.

[Differentiated approach to the choice of the treatment method for pancreatic pseudocysts].

The results of treatment of 182 patients, suffering pancreatic pseudocysts, were analyzed. Total of 226 operative interventions were performed. Under ultrasonographic control 142 (78.

[Methabolism of connective tissue in patients with complicated chronic pancreatitis].

A content in the blood serum of a free and connected oxyproline, collagenolytic activity of the blood, the level of glycosaminoglycans and elastase activity was detected in chronic pancreatitis (CHP). There were examined 73 patients (64 men and 9 women). CHP in a stage B (according to M.

[Surgical treatment of chronic pancreatitis based on classification of M. Buchler and coworkers].

The results of surgical treatment of 452 patients, suffering chronic pancreatitis (CHP), were analyzed. The CHP classification, elaborated by M. Buchler and coworkers (2009), based on clinical signs, morphological peculiarities and pancreatic function analysis, contains scientifically substantiated recommendations for choice of diagnostic methods and complex treatment of the disease.

[Surgical tactic in patients with high risk of occurrence of the intestinal anastomoses sutures insufficiency].

The prognosis criteria for development of the intestinal anastomoses sutures insufficiency were elaborated, basing on analysis of the risk factors occurrence. Surgical tactic of treatment of the patients was substantiated, depending on the risk grade presence. In presence of high or moderate risk of the sutures insufficiency occurrence the methods of the deferred intestinal anastomoses formation were elaborated, excluding necessity of multistage intraabdominal operative interventions performance.

[Application of somatulin in the treatment of complications after operations on the pancreatic gland].

The results of treatment of 32 patients with complications, occurring after operations on pancreatic gland, ended by the external pancreatic fistula formation, in the complex of their treatment Somatulin, somatostatin analogue of prolonged action, were studied. Application of the treatment tactics proposed have permitted to achieve the fistula closure in all the patients without the operative intervention. The terms of the pancreatic fistula closure after Somatulin injection had constituted 5-20 days, (11.

[Using tactics of damage control in complex treatment of the abdominal cavity organ injuries and pancreatitis complicated by severe bleeding and vasodilatation shock].

The results of surgical treatment analysis was conducted in 39 injured persons, aged 16-74 yrs, who suffered severe trauma and pancreatitis and in whom the Damage Control tactics (DCT) was applied for massive bleeding and vasodilatation shock occurrence. According to TRISS scale for injured persons, suffering severe trauma, operated on using the DCT principles, the primary "approximate" prognosis of the death ("blunt") had constituted (37.4 +/- 24.

[Role of nitric oxide and lipid peroxidation in pathogenesis of acute experimental pancreatitis].

In experiment, conducted on 130 Wistar line rats, there was studied up the influence of nitric oxide on the peroxidal oxidation of lipids intensity, activity of enzymes of the antioxidant defense system and morphological changes in acute pancreatitis. Modern suggestions about the influence of the nitric oxide system on pathogenetic mechanisms of an acute pancreatitis and possibilities of correcting therapy were scrutinized. It was established, that the nitrates and the nitrites content in the blood serum of experimental animals correlates positively with the pancreatic oedema index and severity of its morphological changes as well.

[Curative-tactical approaches in patients with pancreatic pseudocyst].

Experience of treatment in the clinic of 162 patients with pancreatic pseudocyst was analyzed. Modern principles of diagnosis and treatment of patients were adduced. Operation before the cyst capsule formation is compulsory, caused by the complications occurrence and the pancreonecrosis progression.

[The role of endothelin-1 in the pathogenesis of septic shock in the abdominal sepsis].

Role of endoteline-1 (ET-1) in pathogenesis of septic shock (SS) was studied in 22 patients in the age from 34 to 58 years. There was shown, that ET-1 content in plasma depends on functional level of the adaptation-compensation reaction of organism as an answer on occurrence of SS in patients with abdominal sepsis. This is demonstrated by more high concentration of the index studied in the patients survived and also presence of correlative connection between ET-1 level in plasma of blood, indexes of middle arterial pressure and general peripheral resistance of vessels.

[Re-laparotomy and damage control during surgical treatment of postoperative intra-abdominal purulent-septic complications].

The issues of pathophysiology, diagnosis and surgical treatment of postoperative intraabdominal purulent-septic complications were suggested. Noncontrolled abortion of mediators with subsequent development of inflammation and damage in the organs, localized far from primary focus, constitutes the main factor of the postoperative intraabdominal purulent-septic complications occurrence. In such a situation the intraabdominal hypertension and abdominal compartment syndrome also promote the deepening of multiple dysfunctions of organs due to mechanical failure of functions in respiratory, hemodynamical, excretional systems of the organism, what promotes the development of vicious circles and the cascade reactions, leading to exitus lethalis.

[Assessment of risk of thromboembolism in patients undergoing surgery].

The risk factors of venous thromboembolism (VTE) in 1146 patients who were underwent operated for the diseases of digestive organs, for obliterating atherosclerosis of abdominal aorta and peripheral arteries, diseases of bones and joints were studied. The methods of VTE prevention in these patients were studied. To evaluate the risk of VTE we designed the special chart.

[Prognosis of postoperative period outcome in patients with critical ischemia of lower extremities after reconstructive surgery of aorta and arteries of lower extremities, using synthetic transplant].

Basing on results of retrospective analysis of 596 case record were detailed prognostically significant signs as a table was elaborated, allowing to prognosticate the late follow up results of treatment in patients with critical ischemia of lower extremities.

[The role of immune disorders in formation of local and systemic complications of severe acute pancreatitis].

There were studied the factors, which initiate the immune response in severe acute pancreatitis, in 57 patients of both gender ageing from 16 to 66 years, in whom the acute pancreatitis severity had constituted 3 marks and more (according to the Ranson criterions). In majority of the patients the combined type of the immune disorders had prevailed. The first stage of the disease was characteristic for metabolic hyperactivity occurrence with raising of HLA-DR+ level as well as of immunoregulating coefficient at the expense of the T-helpers quantity increase.

[Chlamydiosis of the upper sections of the digestive tract].

The experience is submitted gained with the diagnosis and treatment of Chlamydia trachomatis-associated esophagitis. Used in the study were laboratory and instrumental methods of diagnosis, with their merits and demerits outlined. It is pointed out that complex diagnosis of Chlamydia trachomatis-produced esophagitis is important, the treatment involving institution of anti-bacterial and immunomodulating therapies.

[Surgical treatment of integumentary tissues of foot and shin using adhesive dermal tension and cryotherapy].

The first experience of performance of plasty for nonhealing wounds and ulcers of foot and shin, based on grafting of the surrounding skin on the defect region, using stimulating atraumatical adhesive dermotension independently and in combination with cryotherapy, was presented. The methods proposed were applied in 21 patients for restoration of bearing and other tissues of foot and shin, when defect was up to 110 cm2, since 1996. Positive result of treatment was noted.

[Regulation of regeneration processes by synchronous cellular response to the wound cryo-application distance and its influence on wound healing].

Possibility of correcting regulation of regeneration while timely adjusted answer of cells on cryoaffection was established in experiment. In such a situation a small elastic, not protruding cicatrix arises, the healing duration of the wound reduces by 15%.

[Modern aspects of diagnosis and treatment of acute pancreatitis].

Problems of pathophysiology, diagnosis and main principles of treatment of an acute pancreatitis were considered. An early accurate diagnosis, taking into account form of the disease, prognostication of his course, application of modern intensive therapy, obligatory prophylaxis and treatment of systemic inflammatory reaction and the early (noninfectional) and late (infectional) syndrome of polyorganic dysfunction, conduction of endoscopic intervention in systemic-toxic phase of the disease, adequate choice of operative method in presence of pancreatic infection are promoting the reduction of the disease course severity and the mortality lowering.

[Clinical value of determination of the blood elastase activity as a marker of postoperative pancreatitis].

For diagnosis of postoperative pancreatitis 50 patients were examined after performance of organ-preserving operation for gastroduodenal ulcer disease. In 15 patients various postvagotomy symptoms occurred. In 12 of them the elastase activity in blood was increased already in 12 h after operation, lowering gradually under the influence of specific therapy.

[The role of the intestine in the pathogenesis of the multi-organ dysfunction syndrome in diffuse peritonitis].

Extraction of oxygen (O2), ultrastructural organization of intestinal macrophages and translocation of microorganisms were studied on 50 male rats of Wistar line in 2, 6, 12, 24 and 48 hours after the stimulation operation performance (control group) and modelling of an acute purulent peritonitis (APP)--basic group. Increase of common and lowering of intestinal extraction of O2 in early terms of the APP occurrence, accompanied by intensive reproduction of microorganisms and change of intestinal biocenosis, was noted. These infringements correlated with translocation of microorganisms through mesenteric lymphatic nodes--ductus toracicus--systemic blood flow (basic way) in term up to 24 hours and through portal vein--hepar--systemic blood flow (additional way)--up to 48 hours after the APP beginning.

[Reconstructive reoperations on abdominal aorta and main arteries of extremities in the synthetic prosthesis thrombosis].

The results of surgical treatment of 176 patients aging from 42 to 75 years, to whom earlier the reconstruction operation on abdominal aorta and the lower extremities main arteries was performed, were analyzed. The causes of the synthetic prosthesis thrombosis occurrence were studied, individualized surgical tactics, depending on the hip arteries inflow and outflow, was substantiated. There was proposed an access to a.