[Properties of plasma low density lipoproteins in patients with hypertriglyceridemia and ischemic heart disease].

It has been shown that low-density plasma lipoproteins in patients with ischemic heart disease and hypertriglyceridemia are heavier in density, smaller in size, more negatively charged and more inclined to peroxide modification and aggregation than in healthy persons. The protein in the composition of such lipoproteins deviates towards the water phase, which may result in the masking of the domen, recognized by the BE-receptor and may lead to hyperlipidemia of a retaining character.

[Recurrent cardiac crises in patients with post-infarction cardiosclerosis].

Macrofocal myocardial infarction survivers with repeated cardiac accidents (sudden death and repeated myocardial infarction) in the post-infarction period (a 5-7-year follow-up) differ from similar patients with a stable course of the disease by a greater incidence and persistence of such risk factors as smoking and hyperlipoproteinemia. A thorough and maximally possible correction of these factors is necessary. Regular ergometric tests allow the identification of a high risk group for repeated cardiac accidents among patients with a history of an uncomplicated myocardial infarction.

[Lipolytic activity in blood plasma of patients with ischemic heart disease after administration of heparin on an empty stomach and with simultaneous fatty loading].

Effect of heparin on the lipoprotein lipase activity was studied after its administration into fasting and fat loaded patients with heart ischemic disease, exhibiting various lipoprotein spectrum of blood. Heparin activated more distinctly the lipolytic enzymes in the patients kept on fatty diet as compared with the fasting patients. The difference was maximal in the patients with the IIa type of hypolipoproteinemia and minimal--in the patients with the IV type of the disease.

[Results of the bicycle-ergometric tests in post-infarct cardiosclerosis].

Long-term follow-up of 70 patients who had suffered myocardial infarctions included clinical, and regular ergometric examinations. For conducting therapeutic and rehabilitation procedures it suggested to study the changes in the following indices: myocardial reserve consumption coefficient, the total ST segment shift during the exercise. The results of 513 examinations showed that these indices may help practicing cardiologists in choosing the tactics of the therapy and rehabilitation of the patients with chronic ischemic heart disease.

[Lipoprotein lipase activity of ischemic heart disease patients with different types of hyperlipoproteinemia on the basis of fat loading].

Lipolytic activity was distinctly increased in blood plasma of patients with ischemic heart impairment and various types of hyperlipoproteinemia after a test breakfast. The increase in lipolysis was due to elevation in the lipoprotein lipase activity in response to loading with lipids. Attempts to distinguish among the ischemic patients some subgroups on the basis only of the initial level of triglycerides in their blood plasma did not exhibit any differences in the enzymatic activity after the loading with lipids.

[alpha-lipoprotein cholesterol and its variability in ischemic heart disease].

The authors conducted a repeated examination of 150 patients suffering from ischemic heart disease with normolipidemia and types IIa, IIb and IV hyperlipoproteinemia. The content of alpha-cholesterol in these patients tended to fluctuate, just as the content of other blood lipid fractions. Its fluctuations were most marked in types 11b and IV hyperlipoproteinemia.

[Disorder of circadian lipid rhythms in ischemic heart disease].

Thirty-six healthy males and 157 males with ischemic heart disease were examined. Healthy males had statistically significant changes in the daily rhythm of cholesterol, triglycerides, glucose, and total blood serum lipids, while the rhythms of nonesterified fatty acids, total phospholipids, and overall content of beta- and pre-beta-lipoproteins were statistically insignificant. Patients with ischemic heart disease had statistically significant rhythms of cholesterol, triglycerides, total lipids, and total phospholipids, while the daily rhythms of nonesterified fatty acids, glucose and the overall content of beta- and pre-beta-lipoproteins in blood serum were statistically insignificant.

[Comparative analysis of incidence of main risk factors, behavior characteristics and work activity in ischemic heart disease with normolipemia and hyperlipoproteinemia type II and IV].

Examination was conducted of 180 healthy males 35 to 44 years of age, working as leading engineers, and of 174 patients with ischemic heart disease selected according to sex and occupation. A comparative analysis was made of the frequency of the main risk factors and some peculiarities of the labour activity and behaviour of patients with types II and IV hyperlipoproteinemia and those with normal lipid level. It is shown that a combination of known risk factors, behaviour peculiarities and conditions of labour activity is typical of patients with type IV hyperlipoproteinemia, which may promote the development of ischemic heart disease.

[Lipid level in the blood, based on multiple study data, and the characteristics of the course of ischemic heart disease].

The blood lipid content and lipoprotein spectrum were repeatedly tested in 216 males with ischemic heart disease for follow-up periods of 4 to 5 years. Irrespective of the type of hyperlipoproteinemia, the blood triglyceride level was marked by the greatest individual fluctuations and the level of total cholesterol by the least fluctuations. Comparison of the clinical course of ischemic heart disease with the peculiarities of the changes in the blood lipid content revealed a higher incidence of recurrent myocardial infarction and sudden death among individuals with type IIa hyperlipoproteinemia.

[Types of hyperlipoproteinemia in young persons with ischemic heart diseases engaged in strenuous mental work].

The results subsequent to an examination of 250 males aged 30-47 suffering from ischemic heart disease and doing strenous mental work are presented. Two variants were used in phenotyping: the first was based on not too high criteria for the cholesterol and triglycerides level (250 and 140 mg%, respectively), the second one having as a groundwork upper limits of the normal value estimated by the authors (250 and 190 mg%, respectively). It was found that, depending upon the actual value of the upper normal limit for triglycerides hyperlipidemia is demonstrable in 64 or 56% of the males.

[Use of miskleron in ischemic heart disease with differing types of hyperlipoproteinemias].

The effect of Misclerone (clofibrate) was studied in 127 patients with different types of hyperlipoproteinemia treated with the drug for 1 month and longer. On the basis of the obtained data it was concluded that Misclerone is effective both in patients with isolated disorders in cholesterol metabolism (Type II), and in those with cholesterol and triglycerides metabolism disorders (Types IIb and III), and in those with prevailing triglycerides metabolism disorders (Type IV). The efficacy of the drug in Type II hyperlipoproteinemia is determined by the degree and nature of metabolic disorders of low density lipoproteins.

[Diurnal fluctuations of blood lipids and sugar level in healthy persons and in patients with ischemic heart diseases].

Diurnal fluctuations in the level of cholesterol, phospholipids, triglycerides, NEFA and sugar in the blood of practically healthy subjects and in patients with ischemic heart disease, attended by hyperlipoproteinemia of the II and IV types, were studied. Investigations were made at 9 a.m.