[Structural and functional organization of the cerebral cortex neurons in rats with various resistance to emotional stress following administration of delta-sleep-inducing peptide].

In Wistar rats with different resistance to emotional stress (ES), subjected to stress exposure (SE), the structural organization of neurons in layer V of sensomotor cortex was studied quantitatively in brain sections stained using Nissl's cresyl violet method. One group of animals was injected with delta sleep-inducing peptide (DSIP) 1 hr before SE. In rats of control group predisposed to ES, the amount of normochromatic and moderately hypochromatic neurons was decreased as compared to the rats resistant to ES.

[The morphological validation of the pathogenetic prerequisites for analgesic operations in the area of the foramina of the posterior roots].

Since 1983, a hundred and forty-five analgesic operations on the entry areas of the posterior roots were made in patients with deafferentational pain syndrome. Intraoperative findings made the authors reassess the pathogenetic mechanisms responsible for the pain syndrome and induce them to perform a thorough morphological studies of the changes occurring in the diseased posterior roots of the spinal cord and other regions of the nerve system. The morphological study was made on 20 rats that had developed chronic pain syndrome due to abruption of the brachial plexus from the spine.

[The functional and morphochemical characteristics of the hippocampal neurons during the formation of trace processes in old rabbits].

Trace rhythmic activity of dorsal hippocampal neurons were studied after the long-lasting (10-20 min) rhythmic (0.5-2 Hz) electrocutaneous stimulation of the forelimb in alert young (5-7 months), middle-aged (54-65 months), and very old (66-84 months) rabbits. During aging the number of spontaneously active neurons was shown to be significantly decreased, the proportion of slowly firing neurons to be increased, the interspike intervals and intervals between spike groups to lengthen, and the number of spikes per a group to be reduced.

[The morphofunctional characteristics of the neurons in the sensorimotor cortex of old rabbits during the trace assimilation of rhythm].

Extracellular neuronal activity was recorded from 460 neurons from alert young (5-7 months), middle-aged (54-65 months) and old (66-85 months) rabbits. Trace rhythmic activity of sensorimotor cortical neurons was examined after long-lasting (10-20 min) rhythmic (0.5-2 Hz) electrocutaneous stimulation of the contralateral forelimb.

[Changes in the cytoarchitectonics of the field 4 of human cerebral cortex in perinatal developmental defects].

Knowledge of the morphological characteristics is essential for the understanding of the pathogenesis and finding of effective treatment for children with perinatal brain disorders (cerebral palsy). The authors studied histological sections (Nissl-stained) of field 4 of the cerebral cortex from 20 patients aged 3 to 14 years. Demonstrating the signs of nonspecific changes in the nervous tissue and revealing the damage of development, the results of the work can be used for interpreting the data of a quantitative image analysis of the cortex cytoarchitectonics.

[Long-term pathomorphologic changes in the neurons of the rat brain following irradiation with carbon ions and gamma rays].

Quantitative and qualitative morphological changes in neurons and glia of rat brain were studied one month after exposure to accelerated carbon ions 4 GeV/nucleon (LET-76 MeV cm2.r-1) and gamma-radiation (137Cs, 0.25 to 4.

[Incidence of morphologic changes in cerebral cortex neurons of the rat exposed to accelerated carbon ions].

Structural lesions in neurons of the brain cortex of rats were investigated 1 and 3 months after their exposure to accelerated carbon ions with the energy 320 MeV/nuclon 10(4) particles/cm2 (LET = 120 MeVcm2/g) as well as to gamma-radiation in the dose 1.0 Gy. The irradiated animals showed morphofunctional, dystrophic and reparative lesions in neurons.

[Changes in the structures of the cerebral cortex in experimental atherosclerosis with and without exposure to sound].

Albino rats fed an atherogenic diet for 3 months developed a marked depression of the anti-coagulation system of blood. The acoustic and sensomotor cortex showed dystrophic changes in the cortical structures, as well as signs of the reparative nature. Sound stimulation in the presence of atherosclerosis increased fibrinolytic activity and decreased heparin tolerance of blood plasma in animals sensitive to acoustic exposure and led to a greater severity and dissemination of dystrophic and destructive changes in the cortical structures, particularly in animals with convulsive seizures.

[Effect of hyperbaric oxygenation on the course of experimental brain edema].

The authors studied experimental brain edema and morphological changes in the cerebral tissue in 2 groups of animals: the test group receiving hyperbaric oxygenation (HBO) and the control group. The test animals showed a more favourable course of brain injury. Microscopic examination revealed a lesser degree of brain edema and intensification of reparative processes in the cerebral tissues of animals receiving HBO.

[Features of cerebral cortical pathology in children with perinatal encephalopathy in infantile cerebral palsy].

The results of a clinico-morphological examination of 4 patients with perinatal encephalopathy and 2 patients with infantile cerebral paralysis who died of intercurrent diseases at the age of 1 to 8 months are presented. It has been established that considerable alterations in the cytoarchitectonics in the cortical portions of the brain correlate with the functional disorders of cortical-subcortical interactions in these patients, particularly in grave course of infantile cerebral paralysis.

[The effect of several psychotropic substances on brain structure].

The authors have shown similarities of structural changes in the neuron and interneuronal relations found in the brains of rats under indopan and LSD stimulation of the CNS with certain differences in the localization of the changes in the functionally different brain systems. A high sensitivity of the sensory-motor cortex and the subcortical formations of the brain, rich in dopamine and serotonin, to indopan has been marked. LSD central effects were conditioned by the influence of the drug not only on the synapsis, but on the cell body components of the different brain systems, especially in the visual.