Omega-3 fatty acids as a treatment option in periodontitis: Systematic review of preclinical studies.

Periodontitis presents as a chronic inflammatory disease that affects the gingival tissues and structures surrounding the tooth. However, the existing approaches for periodontitis do not allow complete control of the disease. In this regard, an active search is being carried out both in preclinical and clinical studies for new approaches based, among other things, on nutraceuticals.

Cellular and Molecular Genetic Mechanisms of Lung Fibrosis Development and the Role of Vitamin D: A Review.

Idiopathic pulmonary fibrosis remains a relevant problem of the healthcare system with an unfavorable prognosis for patients due to progressive fibrous remodeling of the pulmonary parenchyma. Starting with the damage of the epithelial lining of alveoli, pulmonary fibrosis is implemented through a cascade of complex mechanisms, the crucial of which is the TGF-β/SMAD-mediated pathway, involving various cell populations. Considering that a number of the available drugs (pirfenidone and nintedanib) have only limited effectiveness in slowing the progression of fibrosis, the search and justification of new approaches aimed at regulating the immune response, cellular aging processes, programmed cell death, and transdifferentiation of cell populations remains relevant.

Adjunctive use of omega-3 fatty acids in combination with low-dose aspirin in periodontitis: Systematic review and meta-analysis.

Periodontitis is one of the most common dental diseases with a range of treatment approaches, including pathogenetically reasonable use of various host immune modulators. One such approach is the use of omega-3 polyunsaturated fatty acids (PUFAs) in combination with low-dose aspirin. This systematic review and meta-analysis were performed to compare the standard treatment alone and adjunctive use of omega-3 PUFAs in combination with low-dose aspirin with or without standard treatment in patients with periodontitis.

Immunohistochemical Expression of VDR in Myocardium: Postmortem Evaluation of COVID-19 Patients.

Morphological data on heart damage and its mechanisms due to extremely severe course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are limited, as well as data on the correlation of damage and expression of vitamin D receptors (VDRs). In this study, we analyzed a series of myocardial samples obtained during postmortem autopsy of 48 critically ill patients with COVID-19 who died with SARS-CoV-2-associated pneumonia. The purpose of the study was to evaluate immunohistochemical VDR expression in the myocardium.

[The history of the discovery of Gasserian ganglion].

The article presents in detail the history of the discovery of the trigeminal ganglion in the context to name it Gasserian ganglion. The historical, formal and logical methods of research, along with system analysis were used in the work. An in-depth research of little-known literature sources, which included scientific, publicistic and fiction components, was conducted.

[Antonio Benivieni (1443-1502), Physician of the Renaissance].

Antonio di Paolo Benivieni (1443-1502) is one of the greatest physicians of Renaissance unfairly forgotten at the present time. Benivieni, in his major work of all his life «De abditis nonnullis ac mirandis morborum et sanationum causis», presents not only description of pathologic alterations (including the first in history description of carcinoma of pyloric part of stomach, mesenterial occlusion, fibrinogenous pericarditis) discovered at dissection but he tries to analyze and compare pathologic anatomic and clinical data. The treatise itself is the first in history pathologic anatomic work.

Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report.

Leiomyomatosis peritonealis disseminata (LPD) is a benign disease characterized by the presence of multiple small nodules on the omentum, parietal, and visceral peritoneum. It corresponds to leiomyoma and often resembles metastases of malignant tumors; however, with favorable prognosis. Here we describe a 46-year-old woman, diagnosed with LPD, to demonstrate the etiopathogenesis of the developed leiomyomatosis following endoscopic extirpation of the uterus with the use of a power morcellator.

[Costanzo Varolio (1543-1575) - a significant personality in the development of neuroanatomy].

The biography of outstanding physician and anatomist Costanzo Varolio (1543-1575) is considered. His contribution to the study of the structure of the nervous system is characterized. The authors have translated fragments of his works concerning a method of brain dissection and pons later named in his honor.

[Revisiting eponyms of arteries of the brain].

This article describes the eponymous terms in anatomical nomenclature of the cerebral arteries. There are historical references revealing the etymology of described eponyms, including information about the professional and personal life of doctors and scientists who had first discovered or described particular structure of the cerebral arterial network. Chronology of the discovery of the cerebral arterial circle is described in details.